薬剤耐性（AMR - maff.go.jp

1 AMR JVARM 28 JVARM Japanese Veterinary Antimicrobial Resistance Monitoring System 1999 : 1999 30 : JVARM Japanese Veterinary Antimicrobial Resistance Monitoring System 32 JVARM Japanese Veterinary Antimicrobial Resistance Monitoring System 1999 MIC 2000 2003 2004 2007 2008 2015 / 2016 2020 AMR)

2 AMR 1,059 t 233 t226 t753t 1,292 t 979 t2001 2014 143 t ( 63%) 0501001502002503003504004502006200720082 00920102011 TCPC +TMP ECDC AMR Surveillance report 2012, Murakiet al., Infection. 2013; 41:415-23. AMR defined dose/1,000 / Rev. sci. tech. Off. int. Epiz., 2014, 33 (3)Y. Hosoiet al. Sales of veterinary antimicrobial agents fortherapeutic use in food-producing animal species in Japan between 2005 and 2010 Quantities of veterinary antimicrobial agents sold for therapeuticuse in Japan in mg/kg biomass of the respective target species, (JVARM)1999 2015 27,240 * *Campylobacter Salmonella Total 19991,0181,024166124194318 2000~20032,2061,386956183211394 2004~20071,9791,920679179482661 2008~20091,2951,273390 371371 2010~20111,5671,432540 325325 2012~20131,4811,486464 369369 2014~20151,3331,400464 343343 TOTAL10,8799,9213,6594862,2952,781 CefazolinCeftiofur : 2000~2009, Cefotaxime: 2010~201142 The resistance rate of cephalosporin in E.

3 Coliisolates from healthy broilers HikiM et al. Foodborne Pathog Dis. 2015 Jul;12(7):639-43. 3 ESBL DANMAP 2014 The reductions are, most likely a result of the discontinued use of 3rd generation cephalosporinsin the top of the breeding pyramids in the country producing the has led to a reduction in imported parent flocks harbouringESBL genes. NalidixicacidFluoroquinolone(Enrofloxaci n:2001~2009,Ciprofloxacin:2010~) C. jejuniC. coli ASSuT Salmonella 4,[5],12:i:- NARMS 2012-2013 S. Typhimurium DANMAP 2014 S. Typhimuri 197 4,[5],12:i:- 230 ASSuTASSuTASSuTASSuTCiprofloxacinTMPC iprofloxacinCiprofloxacinCiprofloxacinTM PTMPTMP JVARM JANIS H28 50 JVARM JANIS JVARM JANIS 1999 2000 JANIS JANIS JVARM JVARM JVARM JANIS MIC SIR 2003 2013 6,798 52 JANIS (Ceph) JVARM Ceph 2010 1 Ceph 2012 3 Ceph 2010 3 Ceph BP CTF2/8 g/mL CTX8/64 g/mL)

4 0%20%40%60%20032004200520062007200820092 010201120122013 (ABPC ) JANIS0%5%10%15%20%25%30%2003200420052006 2007200820092010201120122013 (CEZ) 1 JANIS0%5%10%15%20%25%30%2003200420052006 2007200820092010201120122013 CTF / CTX 3 JANIS CTX)CTFCTXCTX2010 CTF BP8 g/mL) CTX(BP 64 g/mL) 0%5%10%15%20%25%30%200320042005200620072 00820092010201120122013 JANIS051015202530352010201120122013 Isolated from broilerCMY-2 CTX-M-1/CTX-M-15 CTX-M-2 CTX-M-25 TEM-135 SHV-12 HikiM et al. Foodborne Pathog Dis. 2015 Jul;12(7) from human 05101520 OtherCTX-M-18 CTX-M-2 CMY-21999 2002 Suzuki S et al. J Antimicrob Chemother. 2009 Jan;63(1):72-9 KojimaA et al. Antimicrob Agents Chemother. 2005 Aug; 49(8): 3533 3537. -Lactamase geneE. coli JANIS 10 3 JVARM 2010 2009 10 0%5%10%15%20%25%30%35%40%200320042005200 62007200820092010201120122013 ERFX / CPFX LVFX JANIS LVFX)LVFXERFXCPFXJVARM 2003-2009 2010 JANIS2003 2006 2007 2013