An invitation to participate in the Saxenda Pharmacy ...

1 An invitation to participate in the Saxenda Pharmacy ProgramKos SclavosSenior Health Strategist Sinapse Pty 879 8308 January 2016 CONFIDENTIAL not to be distributed. The TGA has recently approved Saxenda for use in suitable patients Novo Nordisk is recognised as the leader in diabetes care with over 90 years experience Novo Nordisk has an ambition to become a global leader in the management of obesity, with Saxenda being the first obesity product launch for the company and a pipeline of products currently in development Australia will be one of the first countries to have this product launched Saxenda is the first new prescription medication for obesity available to Australian patients in over a decade Saxenda is an injectable treatment that has been shown to be effective in helping patients lose weight and keep the weight off.

2 For patients who respond to the medication, there is no requirement for them to discontinue use. Novo Nordisk is pleased to integrate community pharmacies into a comprehensive patient support program. Participating pharmacies will be promoted as Saxenda Network Pharmaciesto patients, along with promotion to both primary care and specialist prescribing doctors Saxenda comes in a prefilled pen, which requires needles (not included in the pack). Patients in the support program will be provided needles at charge, when redeemed at Saxenda Network Pharmacies Under the program, patients are to receive Saxenda at a price not exceeding $ for the monthly dose schedule (a 5-pen pack) Saxenda will be part of a Product Familiarisation Program (PFP), which includes the first month escalation dose (titration period) being supplied to the patient as a free sample from their doctor.

3 Patients will therefore approach a Saxenda Network Pharmacy with a prescription following their initial month of therapy. The expected prescription will be for 1 + 2 repeats, though treatment may be ongoing in patients who respond to treatment. Doctors will inform patients of the ongoing price of Saxenda before initiating treatment and enrolling in the PFP An online Pharmacy locator will provide doctors and patients information on where to find their nearest Saxenda Network Pharmacy Indicated for patients with a BMI 27> with a comorbidity, or BMI 30> with or without comorbidities Saxenda not only achieved weight loss for 9/10 subjects in the clinical trial program (and over 10% weight loss for 1 in 3 patients), but also achieved reductions in weight related comorbidities.

4 Blood glucose levels Blood pressure Blood lipids Obstructive sleep apnoea The active molecule is an analogue of a naturally occurring gut hormone that acts centrally and achieves weight reduction by increasing satiety (meaning patients feel a reduced need for energy intake) As with all treatments for weight management, Saxenda will be indicated alongside diet and exercise Saxenda will be injected once daily, regardless of when the patient has eaten a meal The patient should keep unused Saxenda pens in the refrigerator. A Saxenda pen currently in use can be kept at room temperature (up to 30 C) for up to 30 days. The Saxenda pen should be fitted with a new needle each day. Needles are not included in the 5-pen pack. For patients who are enrolled in the support program, they will be able to redeem free needles to suit the Saxenda pen from their Saxenda Network Pharmacy NIS for Saxenda $ Mark Up / Handling Fee$ to Patient$ Professional Service Fee$ Pharmacy Remuneration$ The Saxenda Pharmacy Program is a free information and support service for patients who have been prescribed the medication by their doctor and enrolled in the support program The aim of the support program is to ensure better compliance to medicines, timely access to information and additional value (such as the free needles on 1stand every 3rdscript thereafter) Pharmacists can play a key Quality Use of Medicines (QUM)

5 Role in the program By agreeing to deliver additional care the patient, the Pharmacy may claim a professional services fee of $ from Sinapse (on behalf of the manufacturer) Community Pharmacy Engagement: Better engage with patients on their weight management journey Help facilitate better adherence to their medication Maximise opportunities to increase basket size with patients Deliver further value and professional services to patients Saxenda Network Pharmacies will be promoted to doctors and patients Novo Nordisk will dedicated their existing medical sales force to detailing doctors about Saxenda , including the location of Saxenda Network Pharmacies through detail aids, and an online locator. Doctors will be able to inform their patients of a uniform cost per month, and the provision of additional services and free needles, when filling prescriptions at participating pharmacies.

6 Must be a stock holding of Saxenda at all times. At the time of launch of the medicine and the Pharmacy program, a unit of stock will be sent to each participating Pharmacy as an opening order, via the Pharmacy s nominated price on supply to patients. Supply is on condition that the dispensed price to patients does not exceed $ per 5-pen pack (monthly dose). The likely NIS price for Saxenda will be $ The combined mark-up / handling fee will be $ The professional services fee of $ is in addition to the dispensing remuneration. program counselling by participating pharmacists / interns. Payment of the service fee to a participating Pharmacy is contingent upon the implementation of tasks as outlined in the and audit. For each automated service fee claim, the Pharmacy is required to complete an online eForm.

7 Sinapse reserve the right to access this information for audit purposes. terms. Sinapse, on behalf of the manufacturer, will automatically pay the professional service fee via EFT by the end of the following month in which the service was provided. For this reason banking details are required to be maintained by Supplement Stock. Needles are not included in the medicine 5-pen pack. Patients enrolled in the patient support program are entitled to free needles via redemption at Saxenda Network Pharmacies for the first dispensing, and every third dispensing enrols patient in PSP and provides first month of treatment. After this prescriptions provided. Pharmacist dispenses Saxenda and the Pharmacy Program activated. Patient receives program QUM information and printed material from pharmacist123 Pharmacist monthly claim processed4 PFP / PSP Program CRMM anaged by Sinapse PFP activated.

8 Support program patient (PSP) enrolment List of Saxenda Network Pharmacies is communicated PSP generates unique Patient unique ID to allow processing Pharmacist completes eForm Pharmacist completes information leaflet Discussion facilitated by program collateral Copy of eForm and tailored Information Leaflet to patient Needles supplied of 1stdispensing and every 3rdthereafter Validation occurs Payment made Needles replenished via wholesalerWholesaler needle replenishment 5 PFP/ PSP Program CRMM anaged by Sinapse Claims will be automatically delivered when using the program CRM Pharmacies will receive a $ professional program payment upon dispensing of Saxenda and providing the program service, including needles on the first and fourth dispensingEvery time a patient enrolled with PSP presents a prescription it will include a Unique Patient Code.

9 The data is entered on the eForm on the web portal. By completing the eForm, the pharmacist automatically generates a claim for paymentThe PFP / PSP Program CRM will consolidate all claims based on what s recorded on the eForms and automatically make an electronic payment at the end of each month The program outlines to patients the importance of medication compliance, ensuring health outcomes are Condition: Pharmacy maximum dispense price of $387 / month( ) = $ Condition: Pharmacy must hold at least 1 SKU at all timesProgram Condition:Structured additional QUM support for patientsDispensing remuneration $ Program fee$ Profit / dispense $50 The manufacturer formally invites your Pharmacy group to join the program as a Saxenda Network Pharmacy by signing the Group Commitment letter.

10 Questions to Kos Sclavos Senior Health StrategistSINAPSE Pty Ltd132 Leichhardt St Spring Hill QLD 4004M: +61 415 879