Transcription of ARTにおける黄体ホルモン補充 - kinutani.org
1 2016/7/6 in ART 1. 2. 3. ( ) 6. P4 P4 progesterone receptor, PR 1. ART luteal support first pass effect micronized OC, LEP 2. C-21 C-19 17 - , LD/ULD 2 , 82 7 , 734 MPA, 3- 82 7.
2 735 10 25 10 25 125 65 125 5 2 5 5 5 5 1 82 7 , 735 ( ) ( ) 50 1 125 10 2 2 1 1 82 7 , 736 luteal insufficiency, luteal phase defect, luteal phase deficiency, inadequate corpus luteum, luteal phase inadequancy3.
3 10-30% 25-60% 7 A / , 82 7 , 747 82 7 , 749 31,334 32,676 34,953 38,575 41,619 42,822 44,778 53,873 59,148 63,083 67,714 71,422 82,108 11,653 13,034 15,887 24,459 30,287 35,069 42,171 45,478 60,115 73,927 83,770 95,764 119,089 55,701 60,360 67,672 73,143 83,284 85,859 92,102 112,459 127,081 136,094 153,788 169,169 202,396 050,000100,000150,000200,000200020012002 2003200420052006200720082009201020112012 [ ] 1.
4 25 2012 2014 7 . 66 9 : 2445-2481, 20142. ~jsog- 2008 [ ] ( )1 Progesterone progesterone 2micronized progesterone progesterone 3micronized progesterone progesterone 4 progesterone progesterone 5hydroxyprogesteronecaproate hydroxyprogesteronecaproate 6 hlormadinoneacetate chlormadinone 7dydrogesterone dydrogesterone 8 medroxyprogesterone medroxyprogesterone 9 norgestrel( )
5 82 7 , 754 2012 in ART 77%17%5% or hCG 94 First uterine pass effect First uterine pass effect Cicinelliet al. Hum reprodUpdate 1999;5(4)365-372 20 Gynecol May;18(5) 32 50 or 50 P4 200 mg/ 1. 6,0002. 4003. 98 g145 1. 98g 2. g 145 ml 2 / 60-65 C 55-65 C 3 ml 1 1 ml 5.
6 4 C HP 2014 12 2016 2 4 7 GnRH / HMG/FSH D2/D3 D5 P4 EP00< >D2/D3D54w2d 400 mg/ 300 mg/ 7, 8w P4 < ng/mlP4 ng/ml 100 mg/ GnRH D2/D3 D5 P4 P4 P4 400 mg/ EP00< (HRT >D2/D3D54w2d 400 mg/ 300 mg/ 10w R 600mg/day , R 300mg/day , R 800mg/day 600mg/day 300mg/day 800mg/day P4 3 P4 P4 P4 3 GnRH D2/D3 D5 EPD2/D3D54w2d 600mg/day 300mg/day 800mg/day 10w E2 P4 E2 P4 CGD03 P4 3)
