B12

1 PPI; Proton pump inhibitor H2 H2 H2 H2 PPI 56 5,000 18 8,000 PPI H2 1 1999 2013 4 C. 70 42 PPI colagenous colitis PPI 11 PPI 2 6,436 PPI 2 8,054 PPI PPI 2011 FDA PPI PPI 9 109798 PPI 40% JAMA JAMA Neurology Association of Proton Pump Inhibitors With Risk of Dementia JAMA Neurol.

2 2016;73(4):410-416. PPI Vit B12 Vit B12 30% Vit B12 10439 ARIC PPI PPI (CKD) 50% (AKI) CKD PPI 3 18 244109 PPI 26% 58% 33% Gen Intern Med 2012 9 7 PPI PPI PPI P-CAB Potassium-Competitive Acid Blocker PPI PPI ) Suggests long-term use of acid suppressors might open door to C.

3 Difficile and Campylobacter bacteria ) collagenous colitis 1 . 2015 ; 35 ; 679 682 . Jena AB1 et al Confounding in the association of proton pump inhibitor use with risk of community-acquired pneumonia. J Gen Intern Med. 2013 ; 28 ; 223 230 . Schoenfeld AJ et al Adverse Effects Associated With Proton Pump Inhibitors JAMA Intern Med 2016 ; 176 ; 172 174 . AGA Releases Best Practice Advice on Long-Term PPI Use