【실험동물의 마취】 - bmc-iacuc.org

1 , . , .. , . , . ( , , ) . (narcosis), (relaxation) (analgesia).

2 (1) [ 1] . ( ) .. , .. [ 2] .. , , .. , .(2).

3 , (N2O) .. , , , , ..[ 1. ] Barbiturate Pentobarbital Sodium ( ; Nembutal)- , - : - Thiopental sodium ( )- , - Dissociative anesthetics Ketamine HCl ( ) - ( ) - , - Zoletil ( 50)- Tiletamine( ) Zolazepam(benzodiazepine agent) - (.)

4 ~ , IM) ( 50 )- Hypnotics (Urethane)- - ( -chloralose) - (Tribromoethanol; Avertin)- , , - (Propofol)- Diethyl ether( , ) - - : , , N20 ( )- - Halothane( ) - , - ..Isoflurane( )- , - , , Enflurane ( )- , , ** Halothane,isoflurane,enflurane ~ 2% Atropine Sulfate ( ) Xylazine ( ) diazepam ( )Acepromazine maleate ( )Chlorpromazine ( ).

5 , - - : - - , - barbiturate - , Succinylcholine chloride ( ) Pancronium bromide ( ) Vecuronium bromide ( )- , - - , Acetaminophen ( ) Aspirin ( ) Ibuprofen ( ) Butorphanol ( ) Buprenorphine ( ) Fentanyl ( ) - , , - , , - , - 4-7 , - - ( 50-100 )[ 2.]

6 ] (mg/kg) Pentobarbital30 70 IPRussel & David (1977)40IP, IVFlecknell (1987), Wixson (1990)40 90 IPHughes (1981), Clifford (1984)Thiopental25 50 IVHughes (1981), Clifford (1984)50 90 IPWixson (1990)Ketamine100 200 IMFlecknell (1987), Wixson (1990)Ketamine + Xylazine 100 + 10 IM + IPFlecknell (1987), Wixson (1990)Ketamine + diazepam 200 + 5 IM + IPFlecknell (1987), Wixson (1990)Tribromoethanol(avertin )125IP Wixson (1990), Green (1979)Propofol12 24 IVWixson (1990) / 25 IP / SC Barnes & Etherington (1973)50 IMRussel & David (1977) , IMFlecknell (1987) & Walberg (1987)Acetaminophen300 IPJenkins (1987)Aspirin120 300 POJenkins (1987) (1987) Pentobarbital30 70 IPRussel & David (1977)40 IPFlecknell (1987)Thiopental25 50 IVHughes (1975)30 40 IVFlecknell (1987)Ketamine100 IMFlecknell (1987)Ketamine + Diazepam40 80 + 5 10 IPWixson (1990)Ketamine + Xylazine90 + 10 IMFlecknell (1987)Ketamine + Xylazine40 80 + 5 10 IPWixson (1990)Tribromoethanol(avertin )300 IPFlecknell (1987), Wixson (1990)Propofol10IV(infusion)

7 Wolfensohn (1998) ,SC,IP Russel & David (1977) ,SC,IVFlecknell (1987) & Walberg (1987)Acetaminophen110 300 POJenkins (1987)Ibuprofen10 30 IPJenkins (1987)[ 3.. ] IV ( ), IP( ), IM( ), SC( ), PO ( ) (mg/kg) Pentobarbital Na37 IPFlecknell (1987)15 30 IVHughes (1975)Thiopental Na20 IPMulder (1979)Ketamine22 64 IMHughes (1975)Ketamine + Xylazine45 + 5IM/SCGreen (1979)Ketamine + Diazepam45 + (1987) & David (1977) (1987) Pentobarbital Na15 40 IVRussel & David (1977)20 45 IVClifford (1979)40IP Vanderlip & Gilroy (1981)Thiopental Na20 25 IVSedgewick (1980)30 IPGreen (1979)Ketamine + Xylazine35 + 5 IMHobbs (1990)

8 Ketamine + Diazepam25 35 + 5 10 IMHarkness & Wagner (1983)Propofol10 IVFlecknell (1987) Acepromazine1IM,IVGreen (1979), Lumb & Jone(1984)5 IMFlecknell (1987) ,SC Russel & David (1977)1 3IM,SCGreen (1979) (1987) ,IVFlecknell (1987) Pentobarbital25 30IV Soma (1971),Warren(1983)Thiopental15 30 IVHughes (1975) 22 IMWarren(1983)Ketamine + Xylazine + IVMuir (1989)Propofol6IV- Chloropromazine1 2IM, IVKirk (1977) ,SC,IVKirk (1977) ,SCSawyer (1987) (mg/kg) Pentobarbital25 30 IVRussel & David (1977)Thiopental8 30 IVWarren(1983)Ketamine10 20 IMFlecknell (1987)Ketamine + Xylazine 10 20 + (1987) (1987) Chloropromazine1 / 2IV / IM Lumbs & Jones (1984) ,SC,IVKirk (1977) ,SCSawyer & rech (1987) Pentobarbital24 IVSwindle(1990)10 30 IVRussel & David (1977)Thiopental10 11 IVLumbs & Jones (1984)8 10 IVGreen (1979)Ketamine10 IMFlecknell (1987)Ketamine11 33 IMSwindle(1990)Ketamine + Xylazine20 + 2 IMKyle (1987), Swindle(1990) Chloropromazine1IM Jones (1977) (1987) (1990) (1990) (1990) Pentobarbital30 IVGreen (1979)

9 Thiopental20 IVLumbs & Jones (1984)Ketamine20 IMFlecknell (1987)Ketamine + Xylazine4 + ( )IV + IMFlecknell (1987)Ketamine + Xylazine4 + ( )IV + IMFlecknell (1987)Ketamine + diazepam 4 + 2 IVFlecknell (1987),Green (1979) Chloropromazine1 IVLumbs & Jones (1984) , SCFlecknell (1987) (1987)