Transcription of ガイドブック に おける抗菌剤治療 BRDC
1 27 BRDC 1 2 4 6 8 PK/PD 10 PK/PD 12 14 16 18 19 20 21 M. haemolytica(n=60) 22 P. multocida(n=113) 23 MIC 24 M. haemolytica MIC 22 P.
2 Multocida MIC 22 CLSI MIC 27 Mutant Prevention Concentration MPC 28 29 M. haemolytica P. multocida 31 kg 32 33 34 35 36 37 (BRDC BovineRespiratoryDiseaseComplex)
3 Mannheimiahaemolytica BRDC Bovine Herpesvirus (BHV-1) Parainfluenza 3 Virus (PI3) Bovine Respiratory Syncytial Virus (BRSV) Bovine Viral Diarrhea Virus (BVDV) Mannheimiahaemolytica Pasteurellamultocida Histophilussomni Trueperella(Arcanobacterium)pyogenes Mycoplasmabovis 39-42 C
4 3 3 StaphylococcusStreptococcusCorynebacteri umFusobacteriumProphyromonas ProteusKlebsiellaPseudomonasMannheimiaPa steurellaMycoplasmaLeptospira AMPC ABPC PCG CEZ CQN CTF KM GM SM OXA ERFX OBFX DNFX MBFX StaphylococcusStreptococcusCorynebacteri umFusobacteriumProphyromonas ProteusKlebsiellaPseudomonasMannheimiaPa steurellaMycoplasmaLeptospira TP FFC CL
5 EM TS TMS OTC CTC SDMX SMMX / SMMX/OMP BCM FOM PK/PD Pharmaco-kinetics:PK Pharmacodynamics: PD PK/PD Cmax/MIC MIC Cmax AUC/MIC MIC (AUC) TAM MIC Cmax/MIC AUC/MIC TAM Cp 00 CmaxMIC%TAMCmax/MICAUC/MICTmaxAUC PAEPK-PD %TAM AUC/MIC AUC/MIC AUC/MIC / Cmax/MIC PAE postantibioticeffect 2 PK/PD *(mg/kg) (h)Cmax( g/mL)Tmax(h)AUC(h g/mL) (p37 ) %TAM4 ( ) %TAM10 (.)
6 %TAM15 ( .) 1) %TAM30 ( ) 5) %TAM10 ( .) ** 6) AUC/MIC20 ( .) ) AUC/MIC20 ( ) ) %TAM5 ( .) ) %TAM10 ( ) 15 **8)* * * Cmax Tmax 15 * * * *(mg/kg) (h)Cmax( g/mL)Tmax(h)AUC(h g/mL) (p37 ) Cmax/MIC10 ( .) ) %TAM40 ( .) **10) %TAM1 ( .) ) %TAM4 ( .) ) Cmax/MICAUC/MIC5 ( ) ) Cmax/MICAUC/MIC5 ( .) ) Cmax/MICAUC/MIC2 ( .) **1) Cmax/ ( .) **1) 20 ( .) ) 300 20
7 2 15 MIC MIC MIC MIC MIC50 MIC90 50% 90% MIC MIC90 MIC50 MIC90 MIC50 Mannheimiahaemolytica Pasteurellamultocida MIC - 4250% 251560% - 6583% 644570% 5480% 241979% 50 15 M.
8 Haemolytica(n=60) MIC MIC50 MIC90 % *0 - > - - *0 * 1 - > * 4 - >2564> 1 248 16 12832128 2 444S/T (ST - >76 * CLSI 15 P. multocida(n=113) MIC MIC50 MIC90 % * 4 - - 8*0 *0 * 824 128832 1614S/T (ST - >76 * CLSI 15 MIC MIC MIC Mannheimiahaemolytica Pasteurellamultocida MIC mm <67 8 9101112131415161718192021222324252627282 93031323334353637383940 MIC ( g/mL)162 3 3 2 1 1 6 4 6 22 2125< 2 12 3 4 3 2 2 1 6 6 6 2 2 2 2 1148M.))
9 Haemolytica MIC 15 mm 1516171819202122232425262728293031323334 3536373839404142434445464748495051525354 5556 MIC ( g/mL) < 3 4 2 1 1 4 4 4 2 1 3 2 2 111 37 111321 1 3 4 2 1 2 5 4 4 2 1 3 2 2 111 48P. multocida MIC 15 CLSI MIC (mm)MIC ( /mL SIRSIR G---- 1 30 g 2118 -20 17 24 8 5 g 22-- 5 g 2117 -20 16 2 15 g 1411 -13 10 816 32 30 g 1915 -18 14 24 8 ---- 24 8 CLSI Clinical and Laboratory Standards InstituteS I R Mannheimiahaemolytica, Pateurellamultocida, Histophilussomni 16 Mutant Prevention Concentration MPC MIC MPC MIC MPC MutantSelectionWindow MSW Cp 00 MICMPCMSW 40812162024 Time (hrs) haemolytica/H.)
10 SomniCmax( g/ml)tmax(h) mg/kg5 mg/kg M. haemolytica H. somni MPC MIC 17 17 MSW Cmax( g/ml)tmax(h) mg/kg5 (hrs) multocida mg/kg P. multocida MPC MIC 17 17 21< M. haemolytica P. multocida M. haemolytica50 P. multocida50 CLSI 18 MIC50 MIC90 M. haemolyticaP. multocida< < MPC M. haemolytica8% MPC P. multocida kg 19) 20) 10 12 14 16 18 24 30 36 42 48 60 kg cm 10020030040050006080100120140 cm 01030204050 kg 1002003004005000600709011013050150 2008 19 cm 0530201535 kg 200600400080011 010012014090150 1302510 kg cm 60020040080009011 0100120140150130 2008 19 cm 01030204060 kg 2004006000800709011013050150 50 kg cm 20060040080007080100120150 11013014090 20 1 2 , , , Clin.
