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Calibration Factor/Response Factor - Arizona Department of ...

Response/ Calibration FactorDefinitionsCalibration Factor :A measure of the chromatographic response of a target analyte relative to the mass Factor :A measure of the relative mass spectral response of an analyte compared to its internal : EPA R3 Quality Manual Rev 3 (1/12/04)DefinitionsCalibration Factor :A measure of the chromatographic response of a target analyte relative to the mass Factor :A measure of the relative mass spectral response of an analyte compared to its internal : EPA R3 Quality Manual Rev 3 (1/12/04) Calibration or response Factor representsthe slope of the line between the response for a given standard and the average Calibration Factor or response Factor of the standards for each analyte is then used to calculate the concentration of the : EPA R3 Quality Manual Rev 3 (1/12/04)CriteriaWhen the variation, measured as the relative standard deviation (RSD) of the factors , is less than or equal to 20%, then the slopes of the lines for each standard are sufficiently close to one another that the use of the linear model is generally appropriate over the range of standards that are :SW-846, 8000C, Section relative standard deviation (RSD) of 25% or less is considered : Protocol for EPA Approval of Alternate Test Procedur

Each calibration or response factor represents. the slope of the line between the response for . a given standard and the origin. The average calibration factor or response . factor of the standards for each analyte is . then used to calculate the concentration of . the sample. Ref: EPA R3 Quality Manual Rev 3 (1/12/04)

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Transcription of Calibration Factor/Response Factor - Arizona Department of ...

1 Response/ Calibration FactorDefinitionsCalibration Factor :A measure of the chromatographic response of a target analyte relative to the mass Factor :A measure of the relative mass spectral response of an analyte compared to its internal : EPA R3 Quality Manual Rev 3 (1/12/04)DefinitionsCalibration Factor :A measure of the chromatographic response of a target analyte relative to the mass Factor :A measure of the relative mass spectral response of an analyte compared to its internal : EPA R3 Quality Manual Rev 3 (1/12/04) Calibration or response Factor representsthe slope of the line between the response for a given standard and the average Calibration Factor or response Factor of the standards for each analyte is then used to calculate the concentration of the : EPA R3 Quality Manual Rev 3 (1/12/04)CriteriaWhen the variation, measured as the relative standard deviation (RSD) of the factors , is less than or equal to 20%, then the slopes of the lines for each standard are sufficiently close to one another that the use of the linear model is generally appropriate over the range of standards that are :SW-846, 8000C, Section relative standard deviation (RSD) of 25% or less is considered : Protocol for EPA Approval of Alternate Test Procedures for Organic and Inorganic Analytes in Wastewater and Drinking Water, EPA-821-B-98-002, March 1999 Response/ Calibration Factor EquationsExternal Standard EquationCF = (Ax)/(Cx)orInternal Standard EquationRF = ((Ax)(Cis))/((Ais)(Cx))Where.

2 Ax= Area of the compoundCx= Concentration of the compoundAis= Area of the internal standardCis= Concentration of the internalstandardResponse/ Calibration FactorStatistical EquationsAverage RF or CF:RFAVE= (S RFi / n )Standard Deviation (s):s = { [ S (RFi- RFAVE )2] / (n-1) }Relative Standard Deviation (RSD):RSD = s / RFAVE *100 Where: n = number of pairs of dataRFi= Response Factor for each levelRFAVE= Average of all the response factorsS = the sum of all the individual valuesIn the equations above RF can be replaced with CFResponse/ Calibration FactorEquations for ConcentrationExternal Standard EquationCx= Ax/CFAVEorInternal Standard EquationCx= ((Ax)*(Cis)) / ((Ais)*(RFAVE)) Benefits1. Assumeslinearitythroughtheorigin, Assumeslinearitythroughtheorigin, of the curve is not reflect actual detector response main benefit is that the calculation is very of the curve is not reflect actual detector response main benefit is that the calculation is very simple.


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