생명공학연구소 소개 - career.intron.co.kr

1 ( ) Contents 2015 12 31 20 31 28 , 16 95 iNtRON 1999 , 8 Unit . iNtRON R&BD . , , , BIO Value Chain . Make Real Value !! !! . ! ( ) ( ) ( ) ( ) CTO s Profile Phage Center W Center Unit 1 Unit 2 Unit 3 Unit 4 Unit 5 Unit 6 Unit 7 Unit 8 : : Unit 1 Unit 2 Unit 3 Unit 4 : : : Unit 5 Unit 6 Unit 7 Unit 8 W.

2 INtRON , - , - , , , MRI , project . Unit 1 ( ) Unit 2 Unit 3 Unit 4 - Unit 5 Unit 6 - Unit 7 - Unit 8 MRI iNtRON ( ) ( / /.)

3 ( / ) ( ) ( ) / / ( ) / , , , - - bactericidal activity (N-Rephasin SAL200) N-Rephasin SAL200 pipeline R&D project , , , DNA , (REV-RT) (eHeme)

4 , MRI MRI MRI CM-coated SPIONs, T1 MRI T2 MRI T1/T2 dual-mode MRI , multifunctional MRI - MoA First-in-class drug - - - PSB MF iNtRON ( , 2011) 100 (2011) ( , 2010) 100 (2008) IR22 (2008) (NET) (2008) ( , 2012) ( , 2015) iNtRON The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S.

5 Aureus (MRSA). Appl Microbiol Biotechnol. 99(10):4387-4396, 2015 Preclinical safety evaluation of intravenously administered SAL200 containing the recombinant phage endolysin SAL-1 as a pharmaceutical ingredient. Antimicrob Agents Chemother. 58(4):2084-2088, 2014 Effect of gene amplifications in porphyrin pathway on heme biosynthesis in a recombinant Escherichia coli. J Microbiol Biotechnol. 23(5):668-673, 2013 Mannose-poly(ethylene glycol)-linked SPION targeted to antigen presenting cells for magnetic resonance imaging on lymph node. Carbohydr Polym. 15;92(2):1586-1595, 2013 Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1. Int J Antimicrob Agents 41(2): 156-161, 2013 Porphyrin derivatives from a recombinant Escherichia coli grown on chemically defined medium.

6 J Microbiol Biotechnol. 22(12): 1653-1658, 2012 Carboxylic mannan-coated iron oxide nanoparticles targeted to immune cells for lymph node-specific MRI in vivo. Carbohyd Polym. 88(2): 780-788, 2012 Enhanced Detection of Coxiella burnetii with a Complementary Locked Primer-Based Real-Time PCR Method. Mol Diagn Ther. 15(2): 103-107, 2011 Comparison of the Antibacterial Properties of Phage Endolysins SAL-1 and LysK. Antimicrob Agents Chemother. 55(4): 1764-1767, 2011 (2011~) iNtRON (2011~) A new kanamycin compound, kanamycin producing streptomyces species bacterium, and method of producing kanamycin. US 9,133,492 MRI contrast agent coated with carboxylated mannan and method for producing the same.

7 US8,961,935 Method for selective labeling of protein produced by in vitro translation by using a marker from tRNA prepared by using in vitro transcription. US8,951,757 Antimicrobial protein derived from podoviridae bacteriophage specific to Staphylococcus aureus. US8,377,866 Bacteriophage or lytic protein derived from the bacteriophage which effective for treatment of Staphylococcus aureus biofilm. US8,377,431 A composition for the treatment of ballast water containing bacteriophage as an effective component and biological method with the same for removing bacteria present in ballast water. US8,329,165 Antimicrobial protein specific to Staphylococcus aureus. US8,232,370 Bacteriophage having killing activity specific to Staphylococcus aureus.

8 US8,071,352 (2011~) Novel lysin protein having broad antibacterial activity specific to bacteria. US8,066,990 Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus. US8,043,613 K99 . KR10-1581654 . KR10-1577178 T1 T2 . KR10-1556084 5- , , . KR10-1431453 . KR10-1427075 . KR10-1303567 . KR10-1291052 . KR10-1279780.

9 KR10-1272351 , . KR10-1272454 . KR10-1261292 . KR10-1260655 , , , . KR10-1261131 . KR10-1237233 , , . KR10-1197451 RT-PCR . KR10-1151602 . KR10-1143257 . KR10-1117976 . KR10-1111621 (2011~).

10 KR10-1111351 . KR10-1080607 . KR10-1069115 , , . KR10-1064866 . KR10-1053025 PCR PCR . KR10-1039521 . KR10-1031757 . KR10-1021041 . KR10-1016918 (2011~) iNtRON ( : ) partner ( ) 2,800,000 / / ( )CTC ( Adjuvant ) 2,904,000 ( ) 698,000 ( )CTC / ( ) 4,796,000 / (.)