CCS CONTAINED COMPACTION S DRY …

1 Leading Particle Processing TechnologiesThe Fitzpatrick CompanyCCS SERIES | CONTAINED COMPACTION system DRY GRANULATIONThe Fitzpatrick Chilsonator is the Ideal roll COMPACTION system for Dry Granulation Pharmaceutical Powders > Improve Compact Uniformity & DensityMinimize the degree of ungranulated material to improve downstream powder fl ow characteristics with a unique pre-compression feed system and precision real-time roll gap control > Enhance Operator Safety& Product ContainmentBest-in-class containment features, including WIP (wash-in-place) capabilities and in-wall designs, helps achieve full containment with minimal investment> Minimize Maintenance& Production DowntimeFewer parts with easy access for teardown and cleaning, lead to faster changeovers and a simplifi ed parts inventory> Accelerate Scale-Up& Reduce Development CostsFitzpatrick s application expertise, labcapabilities, support services and scalable equipment parameters ensures faster andmore reliable development and scalabilityThe CCS roll COMPACTION Series from FitzpatrickCCS SERIES CONTAINED COMPACTION System2 | Leading Particle Processing TechnologiesInnovative COMPACTION system > Improves compact uniformity and densityReal-time roll gap feedback control and precision parallel fl oating rolls ensure a more uniform compact for improved downstream particle fl ow> Enhances continuous process stability and scalabilityDirect roll force measurement with integrated load cell and PID control loop allows for a more accurate and repeatable compact densityImprove Compact Uniformity & Density3 Independent.

2 Two-Screw Feed Design > Eliminates the need for vacuum dearationIndependent pre-compression screw removes air from mostpowders prior to the COMPACTION process> Reduces ungranulated bypassSeparate speed control of the pre-compression screw leads to more uniform density and minimizes the degree of ungranulated material passing through the COMPACTION zone without the need for higher roll forcesIndependent, vertical screw pre-compresses material prior to entering the rolls, leading to higher material yields and more uniform compactBar rotor for slow-speed crushing of compact Knife rotor for in air impact of harder compacts Optimized Granulation Process> Controls particle size distributionand minimizes fi nesA greater degree of rotor/screen designs allows for an optimized milling process, leading to tighter PSD ranges> Handles a wider range of powdersThe selection of milling options also allows for the handling and optimization of a wide range of applications, including even the hardest compactsHydraulic ForceFixedRollFloatingRollCCS SERIES CONTAINED COMPACTION SystemFLOOR MOUNTEDCCS 720 The CCS Series is designed to fully contain all product in the processing and receiving sections of the machine.

3 This tightly sealed design allows for the optional product containment system (PCS) to be added at the PCS draws a slight vacuum in the process environment to providemaximum ContainmentSystem (PCS)> Achieves full containment with minimum initial investment> Minimizes product exposure to operator and environment> Prevents product contamination and product loss> Combines with an N2 inerting system to reduce oxygen exposure and explosion risksEnhance Operator Safety & Product Containment | Leading Particle Processing TechnologiesOptional WIP system (Wash-in-Place)IN-WALLCCS 1025IN-WALLCCS 102555 SPRAYSPRAYSPRAY & DISCHARGE5 CCS SERIES CONTAINED COMPACTION System6> Fewer parts to remove during production cycles, allowing for: Faster Changeover Faster Cleaning Less downtime Less inventory formaintenance parts> Easy roll shell removal> Hydraulic system spreads rolls for cleaning> Double lip seal ensures technical area remains sealed while primary seal is removed for cleaning> Components conveniently disassemble from the machine or can be removed as a unit for remote disassembly> Fully automated controls Automatic operation of all components from the operator interface Fully instrumented with convenient display Batch reporting, historical trending and event logging 21 CFR part 11 capable (optional) Multiple levels of password securityMinimize Maintenance & Production Downtime | Leading Particle Processing Technologies7 With our industry-leading COMPACTION technology and application expertise, Fitzpatrick is the ideal partner at every stage, from preliminary analysisto full production.

4 > Our lab service assists in determining if your product is a candidate for roll COMPACTION > Preliminary analysis covers several variables, including moisture tests and pressure vs. density curves> We offer CCS220 rental units or in-house Lab Services to help optimize the COMPACTION process parameters for your powders> The CCS220 is ideal for pilot validation and easily scales to larger production units> All CCS units offer the same diameter rolls, allowing for a more reliable scale-up to a production model, either a CCS720 or CCS1025> Fitzpatrick offers extensive validation and qualifi cation services> Worldwide support ensures your process will keep running to specifi cation7 CCS 220up to 25 Kg/hrCCS 720up to 250 Kg/hrCCS1025 up to 400 Kg/hrCCS 220 CCS 720 Accelerate Scale-Up & Reduce Development CostsMATERIAL PROCESSINGCCSGEN14 Global PresenceWorld HeadquartersIDEX MPT Centers of ExcellenceRepresentation In Over 80 Countries Worldwide832 Industrial Drive Elmhurst, IL 60126 TEL: | FAX: | EMAIL.

5 | MillingRoller CompactionConical MillingHigh Shear MixingHigh Pressure HomogenizationCell DisruptionLean Powder HandlingBatching, Mixing and PackingWorld HeadquartersRepresentation In Over 80 Countries WorldwideIDEX MPT Centers of ExcellenceGLOBAL PRESENCEM aterials Processing Technologies