甘み物質の化学 - chem.tsukuba.ac.jp

1 K K K K ( 55 ) ( ) ( ) 100 150 50 100 2,000 3,000 3,000 200 700 100 200 200 OOHOHOHHOOHOOHHOOOH + H2O OOHOHOHHOOHOHOOHHOOHOH OHOHOHOHHOOHOHHOOHHOOHO ( ( )) ( ) OOHOHOHOOOOHOHOHOHHO a O b a-1,4 b-1.

2 4 1 2 3 4 OOHOHOHOOOOHOHHOO OOHOHOHHOOOHOHOHOHO OOHOHOHHOOOOHOHHOOH OOHOHOHHOOHOOHHOOOH OOHOHOHHOOHOOHOOHOH 3 10 50 70% OOHOHOHOOHOOHHOOOHOOHOHOHHO OOHOHHOOHOOHClOClClOOHOHOHHOOHOOHHOOOH 1976 1998 1999 600 test taste OOHOHOHHOOHHOOHOOHOHOOHOHOHHOOHOOHOOHOH OOHOHOHHOOH OHOHOHOHHOOH OHOHOHOHHOOHHH

3 OOOHOHHOOOOHOHOHHOOOOOHOHOHHO 1970 250 90 1 A ( ) OOOHOHHOOCOOOHOHOHHOOCCOOHO = OOHOOCH3OH cm OOHOHOHOOOOHOHOHHOOOHOHOOOHOHOHHOOOOHOHO HHOO Thaumatococcus danielle 2000 1840 W.

4 F. Daniell (1979 ) 3000 200-700 1878 Constantin Fahlberg Fahlberg 73 11 SO2 NHOSO2 NNaO K NSO2 OOK+ 1967 Hoechst Karl ClauB 5, (3H)

5 K 200 HNSO2OO 1937 2 Michael Sveda 30 31 43 44 11 NHSO3Na 10 50 50 43 NHCONH2 OCH2CH3 1965 1970 100 200 NH2 HNCOOCH3 COOHO COOHCH2 CCNH2 HONHCR2R1H COOHCH2 CCNH2 HONHCR2HR1R1 : 1 4 R : 3 6 R1 R1 COOCH3 R CH2C6H5 COOHCH2 CCNH2 HONHCH2 COOCH3R1.

6 8 COOHCH2 CCNH2 HONHCCOOCH3CH3 HCOOHCH2 CCNH2 HONHCCOOCH3HH3C 25 80 COOHCH2 CCNH2 HONHCCOOCH2CH3CH3 HCOOHCH2 CCNH2 HONHCCOOCOOCH3 HCOOHCH2 CCNH2 HONHCCOOCOOCH3 HCOOHCH2 CCNH2 HONHCCOOCOOCH3 HCOOHCH2 CCNH2 HONHCCOOCOOCH3H 300 600 556 880 5,450 7,300 22,200 33,200 7,000 13,000 2007 2002 K 4 ( ) pH NH2 HNCOOCH3 COO-O Alitame 2000 C14H25N3O4S ( ) ( ) CAS 99016-42-9( ) 80863-62-3( ) L- -Aspartyl-N-(2,2,4,4-tetramethyl-3-thiet anyl)-D-alaninamide hydrated FAO/WHO (JECFA) ADI( ) 0 1mg/kg / 14,000 40,000 NHNHNCOOHNOOOOHNHNHNCNHOHNOOOOHNHNNCNHOH OOO (Lugduname) 2007 22 30 1 ORORROROOROROOHOHOHHOOCOHD- HCO-, CH3CO-, CH3CH2CH2CO-, (CH3) 2 CHCH2CO-, CH3CH=CH(CH3)

7 CO- R = ( 8 16 2m COOHOHOHOHOCO-CH=CHOHOHOHCOOHOHCH=CH-COO HOHOOCO-CH=CHOHOH 2 . 20 30 ( 0 5 8 30 30 8 7 16m 260 500 7 3 ()))