Common Abbreviations for Extended Release …

1 Oral Dosage Forms That Should Not Be Crushed (reviewed Feb 2006)Page 1 of 12 CodesExplanationACapsules may be opened and the contents taken without crushing or chewing; soft food such as applesauce or pudding may facilitate administration; contents may generally be administered via nasogastric tube using an appropriate fluid provided entire contents are washed down the dosage forms of the product are available; however, dose, frequency of administration, and manufacturers may differ from that of the solid dosage and/or milk may prematurely dissolve the coating of the tablet. DCapsule may be opened and the liquid contents removed for taste of this product in a liquid form would likely be unacceptable to the patient; administration via nasogastric tube should be tablets must be dissolved in the amount of diluent recommended by the are made to disintegrate under the is scored and may be broken in half without affecting Release contact may enhance tumor production.

2 Avoid direct Abbreviations for Extended Release ProductsCDControlled DoseCRControlled ReleaseCRTC ontrolled Release TabletLALong ActingSASustained ActionSRSustained ReleaseTDTime DelayedTRTime ReleaseXLExtended ReleaseXRExtended ReleaseSummary of Drug Formulations that Preclude CrushingTypeReason(s) for the Formulation4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 2 of 12 Enteric CoatedDesigned to pass through the stomach with drug being released in the intestines to: (1) prevent destruction of drug by stomach acids (2) prevent stomach irritation (3) delay onset of actionxtended ReleaDesigned to Release drug over an Extended period of time. Such products include: (1) multiple-layered tablets releasing drug as each layer dissolves (2) mixed Release pellets that dissolve at different time intervals (3) special matrixes that are themselves inert, but slowly Release drug from the matrixSublingualDesigned to dissolve quickly in oral fluids for rapid absorption by the abundant blood supply of the mouthMiscellaneousDrugs that: (1) produce oral mucosa irritation (2) are extremely bitter (3) contain dyes or inherently could stain teeth and mucosal tissue (4) if handled without proper protection, may potentially be carcinogenic1 Beckwith MC et al.

3 A Guide to Drug Therapy in Patients with Enteral Feeding Tubes:Dosage Form Selection and Administration Methods. Hosp Pharm. 2004;39 JF and Leady MA. Oral dosage forms that should not be crushed or chewed. Hosp Pharm. 2002;37 ZM. Food-Medication Interactions, 13th ed. Birchrunville, PA: Food-MedicationInteractions; 2004 CA and Rollins CJ. Nutrient-Drug Interactions (Chapter 31). In: Rombeau JL and Rolandelli RH, eds. Clinical Nutrition: Enteral and Tube feeding, 3rd ed. Philadelphia, PA:WB Saunders - Harcourt Brace 1997 Drug (explanation)Brand NameDosage FormCode*References:4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 3 of 12 AAcetaminophen ( Extended Release )Arthritis Bayer Time ReleaseTabletTylenol ArthritisTabletTylenol 8 HourTabletAcetazolamide ( Extended Release )Diamox SequelsCapsuleAlendronate (mucous membrane irritant)FosamaxTabletAlbuterol ( Extended Release )VolmaxTabletVoSpire ERTabletProventil RepetabsTabletAlprazolam ( Extended Release )Xanax XRTabletAmoxicillin/Clavulanate ( Extended Release )Augmentin XRTabletB, HAspirin (enteric coated)variousTabletASA EnsealsTabletAscriptin (A/D and Extra Strength)TabletEnteric Coated AscriptinTabletBayer.

4 Enteric Coated, Low Adult, & Regular StrengthTabletEaspirinTabletEcotrin (various)TabletZORprinTabletAspirin/Dipy ridamole ( Extended Release )AggrenoxCapsuleBBenzonatate ( Extended Release )Tessalon PearlesCapsuleBenzphetamine ( Extended Release )BontrilCapsulePrelu-2 CapsuleBisacodyl (enteric coated)variousTabletCarter's Little PillsTabletDucolaxTabletCBisacodyl ( Extended Release )DoxidanTabletBrompheniramine ( Extended Release )AcchistTabletHLodrane LDCapsuleARespahistCapsuleABudesonide (enteric coated)Entocort ECCapsuleABupropion ( Extended Release )Budeprion SRTabletWellbutrin SR and XLTabletZybanTablet4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 4 of 12 Carter's Little PillsTabletCCarbamazepine ( Extended Release )CarbatrolCapsuleTegretol-XRTable tCarbenicillin indanyl sodium (taste)GeocillinTabletCarbidopa/Levodopa ( Extended Release )Sinemet CRTabletCarbinoxamine/pseudoephedrine ( Extended Release )Carbiset-TRTabletPalgic-DTabletH PannazTabletHRondec TRTabletBCefaclor ( Extended Release )Ceclor CDTabletCefuroxime (taste)CeftinTabletBCharcoal - activated/simethicone (enteric coated)Charcoal PlusTabletChloral Hydrate (liquid form within a capsule)various CapsuleBSomnoteCapsuleChlorpheniramine ( Extended Release )Chlor-Trimeton 12-HourTabletBDallergy & Dallergy JrCapsuleDeconamine SRCapsuleBExtendryl (Jr.)

5 , SRC)CapsuleR-TannaTabletRescon Jr. & Rescon MXTabletCiprofloxacin (taste)various TabletECiprofloxacin ( Extended Release )Cipro XRTabletClarithromycin ( Extended Release )Biaxin-XLTabletColestipol ( Extended Release )ColestidTabletCyclophosphamide (maybe crushed; company recommeds IV form)CytoxanTabletDDexbrompheniramine ( Extended Release )Drixoral (various)TabletDisophrol ChronotabTabletDexchlorpheniramine ( Extended Release )variousTabletDextroamphetamine ( Extended Release )Adderall XRCapsuleDexedrine SpansuleCapsuleDiclofenac ( Extended Release )Voltaren XRTabletDiclofenac/Misoprostol (enteric coated)ArthrotecTabletDidanosine (delayed Release with ebteric coated beads)VidexCapsule4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 5 of 12 Carter's Little PillsTabletDiethylpropion ( Extended Release )variousTabletDiflunisal (irritant)DolobidTabletDiltiazem ( Extended Release )Cardiziem & Cardixem LATabletCardizem (CD & SR)

6 CapsuleCartia XTCapsuleDilacor XRCapsuleDiltia XTCapsuleTaztia XTCapsuleTiazacCapsuleDimenhydrinate ( Extended rlease)TriptoneTabletDirithromycin (enteric coated)DynabecTabletDisopyramide: Norpace CR Extended -releaseNorpace CRCapsuleDivalproex sodium ( Extended Release )Depakote (Delayed Release & ER)TabletDivalproex sodium (enteric coated)Depakote SprinkleCapsuleDocusate (taste)ColaceCapsuleEDutasteride (teratogenic potential)AvodartCapsuleEEnalapril/Felod ipine ( Extended Release )LexxelTabletErgocalciferol (liquid-filled capsule)DrisdolCapsuleDErgoloid mesylate (liquid-filled capsule)Hydergine LCCapsuleErgotamine (sublingual)ErgomarTabletGErythromycin (enteric coated) StearateTabletErthromycin baseTabletEsomeprazole ( Extended Release )NexiumCapsuleAEtodolac ( Extended Release )Lodine XLTabletFFelodipine ( Extended Release )PlendilTabletFerrous fumarate ( Extended Release )Ferro-SequelsTabletFerrous gluconate (enteric coated)FergonTabletFerrous sulfate ( Extended Release )

7 Fero-Grad 500 Tablet4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 6 of 12 Carter's Little PillsTabletSlow-FE and Slow-FE FolicTabletFerrous sulfate (enteric-coated)FeosolTabletBFeratabTabl etBFexofenadine ( Extended Release )Allegra-DTabletFiber (wax coated granules)PerdiemGranulesFinasteride (teratogenic)PropeciaTabletProscarTablet Fluoxetine (delayed Release )Prozac WeeklyCapsuleFluvastatin ( Extended Release )Lescol XLTabletGGanciclovir (skin irritant)CytoveneCapsuleGlipizide ( Extended - Release )Glucotrol XLTabletGriseofulvin (crushing may result in ppt as larger particles)Gris-PegTabletGuaifenesin ( Extended Release )Entex LACapsuleBGuaifenex (LA and DM)TabletHHumabid (LA and DM)TabletHHumibid DM & Humibid DM SprinkleCapsuleALiquibid-D 1200 & Liquibid-PDTabletHMucinexTabletMuco-Fen- DMTabletHPhenaVent DTabletSINU tuss DM CRTabletHSINU vent PETabletHTouro (various)TabletZ-Coff LATabletGuaifenesin/Pseudoephedrine ( Extended Release )Defen-LATabletHDuratuss & Duratuss GPTabletHEntex PSEC apsuleGFN/PSE/DMTabletGuaifed, Guaifed-PDCapsuleGuaifenex PSET abletHGuaiMAX-DTabletMaxifed, Maxifed DM, Maxifed GTabletMedent (DM & LD)TabletNasatab LATabletH4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 7 of 12 Carter's Little PillsTabletPanmist (Jr.)

8 & LA)TabletHProfen-II & Profen-II DMTabletHProtuss DMTabletRespa 1stTabletHRespaire SR (60 & 120)CapsuleSudal 500/60 TabletTouro LATabletTussafed LATabletZephrex LATabletHHyoscyamine ( Extended Release )LevbidTabletHLevsinex TimecapsCapsuleSymax SRTabletHyoscyamine/Atropine/Scopolamine /Phenobarbital (slow Release )Donnatal ExtendtabsTabletBIIbuprofen (taste)Motrin TabletEImatinib (taste - may be dissolved in mineral oil or apple juice)GleevecTabletHIndinavir (taste - may be opened & mixed with fruit puree)CrixivanCapsuleIndomethacin ( Extended Release )Indocin SRCapsuleA,BIron with Vitamins ( Extended Release )FumatinicCapsuleIberet (Filmtabs, 500, Folic-500)TabletIsosorbide Dinitrate ( Extended Release )Dilatrate SRCapsuleIsosorbide Dinitrate (sublingual)IsordilTabletGIsosorbide Dinitrate SublingualTabletGIsosorbide Monohydrate ( Extended Release )ImdurTabletHIsosorbide SRTabletIsotretinoin (mucous membrane irritant)AccutaneCapsuleIsradipine ( Extended Release )DynaCirc CRTabletJK4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 8 of 12 Carter's Little PillsTabletKetoprofen ( Extended Release )OruvailCapsuleLLansoprazole ( Extended Release )PrevacidCapsuleLansoprazole ( Extended Release - enteric coated granules)Prevacid SuspensionGranulesLithium ( Extended Release )Eskalith CRTabletLithobidTabletLoratadine/Psudoep hedrine ( Extended Release )Alavert Allergy Sinus 12 HourTabletClaritin-D (12 and 24 Hour)TabletLovastatin ( Extended Release )

9 AltocorTabletMMagnesium chloride ( Extended Release )Mag-Tab SRTabletSlow-MagTabletMesalamine ( Extended Release )PentasaCapsuleMesalamine (enteric coated)AsacolTabletMetformin ( Extended Release )Glucophage XRTabletMetronidazole ( Extended Release )Flagyl ERTabletMethamphetamine ( Extended Release )DesoxynTabletMethylphenidate ( Extended Release )ConcertaTabletMetadate ERTabletMetadate CDCapsuleAMethylin ERTabletRitalin SRTabletMetoprolol ( Extended Release )Toprol XLTabletMorphine ( Extended Release )Avinza (do not give with pudding)CapsuleAKadian (do not give via NG tubes)CapsuleAMS ContinTabletBOramorph SRTabletBMultiple vitamins ( Extended - Release )FumatinicCapsuleIcaps PlusTabletIcaps Time ReleaseTabletOndroxTabletOptilets 500 & Optilets-M 500 TabletMycophenolate (teratogenic)CellCeptCap/TabMyforticTabl et4/25/2005*Code Explanation on Page 11 Oral Dosage Forms That Should Not Be Crushed (2004)Page 9 of 12 Carter's Little PillsTabletNNaproxen (enteric coated)EC NaprosynTabletNaproxen ( Extended Release )NaprelanTabletNiacin ( Extended Release )NiaspanTabletSlo-NiacinTabletHNi acin/Lovastatin ( Extended Release )AdvicorTabletNicardipine ( Extended Release )Cardene SRCapsuleNicotine Polacrilex (integrity compromised by curshing/chewing)CommitLozengeNicotinic acid ( Extended Release )Nicotinic AcidCap/TabNifedipine (delays absoption)ProcardiaCapsuleB,ENifedipine ( Extended Release )Adalat CCTabletAfeditab CRTabletNifediac CCTabletProcardia XL (AUC is unaffected)TabletNisoldipine ( Extended Release )SularTabletNisopyramide ( Extended Release within special capsule)

10 Norpace CRCapsuleNitroglycerin ( Extended Release )NitroglynCapsuleNitroTimeCapsule Nitroglycerin (sublingual)NitrostatTabletGOOmeprazole (delayed Release )PrilosecCapsuleOrphenadrine citrate ( Extended Release )NorflexTabletOxybutynin ( Extended Release )Ditropan XLTabletOxycodone ( Extended Release )OxycontinTabletPPancreatic enzymes ( Extended Release )Creon 5, 10, 20 CapsuleACotazym-SCapsuleALipram (all)CapsuleAPancreatic enzymes (enteric coated)Lipram (4500, CR, PN, UL)CapsuleAPancrease & Pancrease MTCapsuleAPancrecarb MSCapsuleAUltrase & Ultrase MTCapsuleAPantoprazole ( Extended r)