CONTENTS

1 3. CONTENTS . PARTICIPANTS .. v ABBREVIATIONS .. xiii 1. 1. 2. GENERAL CONSIDERATIONS .. 3. Amendments to the agenda .. 3. Risk assessment procedures used by the JMPR .. 3. Improving the assessment of dietary risk of pesticides .. 5. ADIs based on short-term exposure .. 5. Concomitant pesticide and veterinary uses of 6. Validation of studies .. 6. Guidelines on the need for animal transfer studies in estimating pesticide maximum residue 7. Guidelines on the preparation of data submissions to the FAO Panel of the 8. Choice of dose levels in toxicology 8. Mode of action, mechanism of toxicity and toxicological evaluation .. 9. Dietary intake of pesticide residues .. 9. 3. SPECIFIC 11. Measurement of radioactive iodine uptake as in indication of thyroid function .. 11. Evaluation of the 11. 4. EVALUATION OF DATA FOR ACCEPTABLE DAILY INTAKE FOR HUMANS AND.

2 1. MAXIMUM RESIDUE LIMITS .. 13. Aldicarb (R).. 13. Amitrole * (T,R).. 13. Azinphos-methyl (R) .. 17. Benalaxyl (R) .. 18. Bromopropylate * (T,R) .. 20. Carbofuran (R).. 23. Carbosulfan (R) .. 24. Chlorothalonil * (R) .. 26. Chlorpyrifos-methyl (R) .. 29. Cycloxidim (R) .. 30. DDT (R) .. 31. Diazinon * (T,R) .. 32. Dichlorvos * (T,R) .. 40. Diquat * (T) .. 46. Dithiocarbamates * (T,R).. 48. Endosulfan (R).. 49. Ethephon (T).. 50. Ethylenethiourea (ETU) * (T,R) .. 52. Etofenprox ** (T,R) .. 56. Fenbutatin oxide (R).. 60. 1. T = Toxicology; R = Residue and analytical aspects * = evaluation in the periodic review programme ** = new compound 4. Fenpropathrin ** (T,R) .. 67. Fentin (R).. 72. Flucythrinate (R) .. 72. Flusilazole (R).. 73. Folpet (T,R) .. 76. Heptachlor (R) .. 79. Hexaconazole (R).. 79. Mancozeb * (T,R) .. 80. Maneb * (T,R) .. 91. Metiram ** (T).

3 98. Monocrotophos (T) .. 100. Phorate (R) .. 101. Phosalone (T).. 102. Procymidone (R) .. 104. Propineb * (T,R).. 106. Propylenethiourea (PTU) * (T,R).. 110. Pyrazophos (R) .. 111. Triazophos (T,R) .. 112. Zineb * (T).. 114. 5. 117. 6. FUTURE 119. 1994 119. 1995 120. 7. 121. CORRECTIONS TO REPORT OF 1992 JMPR .. 127. ANNEX I, ADIs and 129. ANNEX II, Index of reports and evaluations .. 141. ANNEX III, Intake 151. 5. 1993 FAO/WHO JOINT MEETING ON pesticide residues . Geneva, 20-29 September 1993. PARTICIPANTS. WHO Expert Group on pesticide residues Prof. Ahlborg Division of Environmental Toxicology Karolinska Institutet Institute of Environmental Medicine Box 210. S-17177 Stockholm Sweden Tel: (46 8) 728 7530. Fax: (46 8) 343 849. Dr Black Medical Services Adviser in Toxicology Department of Health, Housing, Local Government and Community Services GPO Box 9848.

4 Canberra 2601 ACT. Australia Tel: (61 6) 289 8464. Fax: (61 6) 289 7802. Professor Borzelleca (Chairman). Pharmacology, Toxicology Medical College of Virginia Virginia Commonwealth University Box 613. Richmond 23298-0613 Virginia USA. Tel: (1 804) 786 8409. Fax: (1 804) 285 1401. Mr Clegg 142 Corkery Woods Drive RR 2. Carp K0A 1LO Ontario Canada Tel: (1 613) 256 4518. Fax: (same as telephone. Call first). Dr Penelope A. Fenner-Crisp (Rapporteur). Director, Health Effects Division Office of Pesticide Programs (H7509C). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (1 703) 305 7351. Fax: (1 703) 305 5147. 6. Dr den Tonkelaar Toxicologist Toxicology Advisory Centre National Institute of Public Health and Environmental Protection Antonie van Leeuwenhoeklaan 9. Box 1. Bilthoven 3720 BA. Netherlands Tel: (31 30) 743 000.

5 Fax: (31 30) 291 492. Dr Peipei Yao Professsor of Toxicology Consultant of ICAMA. Institute of Occupational Medicine, CAPM. Ministry of Public Health 29 Nan Wei Road Beijing 100050. China Tel: (86 1) 301 6891 / 303 8761 256 / 301 0863. Fax: (86 1) 301 4322 / 301 1875. FAO Panel of Experts on pesticide residues in Food and the Environment Dr. Abbott AOAC International, Liaison Representative 80 Chaffers Mead Ashtead, Surrey KT21 1NH. United Kingdom Tel. & fax: (44) 372-274856. Dr. A. Ambrus (Rapporteur). Budapest Plant Health & Soil Conservation Station H-1519. Box 340. Budapest Hungary Tel: (361) 1851 177/(361) 1851 110/(361) 1850 782. Fax: (361) 1869 276/(361) 1869 116. Dr. Ursula Banasiak Stahnsdorfer Damm 81. D-14532 Kleinmachnow Germany Tel: (49) 33203/22423 or 22586 or 22128. Fax: (49) 33203/22278. 7. Mr. Hamilton Senior Principal Scientist Agricultural Chemistry Queensland Department of Primary Industries Meiers Road, Indooroopilly Brisbane, Queensland 4068.

6 Australia Tel: (61 7) 877 9484. Fax: (61 7) 371 6436. Mr. Ives (Vice-Chairman). Health Effects Division (H7509C). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (703) 305-6378. Fax: (703) 305-5147. Dr. Lundehn Federal Biological Research Centre for Agriculture and Forestry (BBA). Messeweg 11-12. D-38104 Braunschweig Germany Tel: (49) 531 299-3450. Fax: (49) 531 299-3003. Mr. K. Voldum-Clausen Tingmosen 5. 3500 Varl se Denmark Tel: (45) 42 48 08 95. Fax: (45) 39 66 01 00. Ms. Yeoh Residue Section pesticides Control Branch Dept. of Agriculture Jalan Gallagher Kuala Lumpur 50632. Malaysia Tel: 603-2983077 ext. 104. Fax: 603-2983646. Secretariat Mrs Arentzen (WHO Temporary Adviser). National Institute of Public Health and Environmental Protection Antonie van Leeuwenhoeklaan 9. Box 1. 3720 BA Bilthoven Netherlands Tel: (31 30) 749 111.

7 Fax: (31 30) 742 971. 8. Dr Elisabeth Bosshard (WHO Temporary Adviser). Federal Office of Public Health Division of Food Science c/o Institute of Toxicology Schorenstrasse 16. Schwerzenbach 8603. Switzerland Tel: (41 1) 825 75 11 / (41 1) 825 74 19. Fax: (41 1) 825 04 76. Mrs M. Caris (WHO Temporary Adviser). Toxicological Evaluation Division, Bureau of Chemical Safety Health and Welfare Canada Room 2-2, HPB Bld. Tunney's Pasture Ottawa K1A OL2 Ontario Canada Tel: (1 613) 957 1688. Fax: (1 613) 941 2632. Dr K. Fujimori (WHO Temporary Adviser). Division of Pharmacology Biological Safety Research Center National Institute of Health Sciences 18-1, Kamiyoga 1-chome Setagaya-ku Tokyo 158. Japan Tel: (81 3) 3700 1141. Fax: (81 3) 3707 6950. Dr H. Galal-Gorchev International Programme on Chemical Safety World Health Organization 1211 Geneva 27. Switzerland Tel: (41 22) 791 3537.

8 Fax: (41 22) 788 1949 / 791 0746. Dr Herrman (WHO Joint Secretary). International Programme on Chemical Safety World Health Organization 1211 Geneva 27. Switzerland Tel: (41 22) 791 3569. Fax: (41 22) 788 1949 / 791 0746. Dr A. Kocialski (WHO Temporary Adviser). Health Effects Division Office of Pesticide Programs (H7509C). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (1 703) 305 7396. 9. Fax: (1 703) 305 5147. Dr Jens-J rgen Larsen (WHO Temporary Adviser). Head, Department of General Toxicology Institute of Toxicology National Food Agency of Denmark 19, M rkh j Bygade S borg 2860. Denmark Tel: (45 39) 69 66 00 ext 4100. Fax: (45 39) 39 66 01 00. Prof. M. Lotti (WHO Temporary Adviser). Universit di Padova Istituto di Medicina del Lavoro via Facciolati 71. Padova 35127. Italy Tel: (39 49) 75 01 55. Fax: (39 49) 82 16 644.

9 Mr Machin (FAO Consultant). Boundary Corner 2 Ullathorne Road London SW16 1SN. UK. Tel. & fax: (44 81) 769 0435. Dr Marrs (WHO Temporary Adviser). Medical Toxicology and Environmental Health Department of Health Skipton House 80 London Road Elephant and Castle London SE1 6LW. UK. Tel: (44 71) 972 5328 / 972 5300. Fax: (44 71) 972 5156. Dr D. McGregor Unit of Carcinogen Identification and Evaluation International Agency for Research on Cancer 150 cours Albert-Thomas 69372 Lyon Cedex 08. France Tel: (33) 72 73 84 85. Fax: (33) 72 73 85 75. Dr A. Moretto (WHO Temporary Adviser). Universit di Padova Istituto di Medicina del Lavoro via Facciolati 71. Padova 35127. Italy Tel: (39 49) 82 16 644. Fax: (39 49) 82 16 644. 10. Dr G. Moy Food Safety World Health Organization 1211 Geneva 27. Switzerland Tel: (41 22) 791 3698. Fax: (41 22) 791 0746. Mr Murray (FAO Joint Secretary).

10 Plant Protection Service Plant Production & Protection Division Food and Agriculture Organization of the United Nations (FAO). Via delle Terme di Caracalla Rome 00100. Italy Tel: (39 6) 5797 3222. Fax: (39 6) 5797 3152. Dr R. Plestina International Programme on Chemical Safety World Health Organization 1211 Geneva 27. Switzerland Tel: (41 22) 791 3592. Fax: (41 22) 788 1949 / 791 0746. Dr A. Takanaka (WHO Temporary Adviser). Head Division of Pharmacology Biological Safety Research Center National Institute of Health Sciences 18-1, Kamiyoga 1-chome Tokyo 158 Setagaya-ku Japan Tel: (81 3) 700 1141. Fax: (81 3) 707 6950. Dr van Eck Chairman, Codex Committee on pesticide residues Food and Product Safety Division Ministry of Welfare, Health and Cultural Affairs Postbox 3008. Sir Winston Churchillaan 362. 2280 MK Rijswijk The Netherlands Tel: (70) 340 69 66.