Continuous Wound Infusion for Postoperative Pain Relief

1 ChemotherapyAnti-infective TherapySystemic AnalgesiaIron ChelationContinuous Wound InfusionRegional AnalgesiaThe Targeted Drug Delivery System Continuous Wound Infusionfor Postoperative Pain ReliefThe Original and still the Leaderyearsof Infusor ExcellenceThe Targeted Drug Deliver y SystemContinuous Wound InfusionContinuous Wound Infusion is a technique which uses a multi-holed catheter to deliver local anaesthetics or analgesics directly into the Wound for Postoperative pain Relief . It can be used as a single technique or as par t of a multi-modal analgesic approach. Effective Postoperative Analgesia The Continuous Wound Infusion of local anaesthetics or analgesics has been proven to provide an effective Postoperative analgesia in in-patients and ambulator y settings to patients undergoing or thopaedic 1 - 4, and thoracic 5, 6 surgical procedures as well as laparotomy 7, hernia repair 8, and C-section.

2 9 Reduces Opioid Usage This analgesic technique reduces the need for systemic opioids in the Postoperative - 9 Safe TechniqueContinuous Infusion of local anaesthetics or analgesics in the surgical Wound for Postoperative analgesia is a safe technique as it does not increase the number of Wound infections 2 - 4, 9, does not impair the Wound healing process 2, 4, 9, and does not generate toxic levels of local anaesthetics in the patient s plasma. 2, 4, 7, 9 Reduce Hospitalisation A few studies found that the Continuous Wound Infusion technique allows for a reduction of the patient s length of stay in hospital. 2, 5, 7 Excellent Patient Satisfaction Continuous Wound Infusion for Postoperative analgesia provides excellent patient satisfaction. 2, 3, 9 Advanced design feature to optimise uniform fl ow distribution High tensile strength indicating low risk of breakage 13 Convenient, easy to use system with peel-away Introducer needle and adhesive included Range of 19 gauge catheters to cover various incision lengths Radioopaque catheter with printing to allow identifi cation of multi-holed section, distance from the beginning of the multi-holed section and tip identifi cation Preconnected hub and hub sleeve minimise the risk of disconnection or kinkingINfusor features and benefi ts.

3 Rigid housing eliminates the effect of accidental external pressure 10 Consistent, accurate fl ow rate 10, 11 Infusion Progress Indicators to monitor the progress of the Infusion at any time Minimal Residual Volume Full range of single-rate and multi-rate products to suit therapy needs Patient Control (PCRA) devices available Validated catheter and Infusor combinations 12 Compatibility tested with a broad range of local anaesthetics and analgesics 11 PAIN fusor Catheter features and benefi ts:For more information on the Baxter Infusors please contact:Austria +43/1 711 20-163 Belgium +32/2 650 17 11 Bulgaria +359/2 980 84 82 Denmark +45/48 16 64 00 Finland +358/9 862 1111 France +33/1 34 61 50 50 Germany +49/6221 39 70 Greece +30/210 99 87 000 Hungary +36/1 20219 80 Ireland +353/12 06 5500 Italy +39/02 535 771 Netherlands +31/30 24 88 911 Norway +47/22 58 48 00 Poland +48/ 22 525 07 77 Portugal +351/219 25 25 00 Spain +34/96 386 0800 Sweden +46/8 632 64 00 Switzerland +41/44 908 50 50 UK +44/1635 206000 Baxter, INfusor and PAIN fusor are trademarks of Baxter International, Inc.

4 MD-ON-050 - Date of preparation 01/08. 2008, Baxter Healthcare Corporation All rights reser ved. for Use is available from your local Baxter Infusors The Original and still the Leader Catheters for Continuous Wound Infusion References: 1. Axelsson K, Nordenson U, Johanzon E, Rawal N, Ekback G, Lidegran G, et al. Patient-controlled regional analgesia (PCRA) with ropivacaine after arthroscopic subacromial decompression. Acta Anaesthesiol Scand 2003 Sep;47(8) Bianconi M, Ferraro L, Ricci R, Zanoli G, Antonelli T, Giulia B, et al. The pharmacokinetics and efficacy of ropivacaine Continuous Wound instillation after spine fusion surgery. Anesth Analg 2004 Jan;98(1):166-72, Blumenthal S, Dullenkopf A, Rentsch K, Borgeat A. Continuous Infusion of ropivacaine for pain Relief after iliac crest bone grafting for shoulder surgery.

5 Anesthesiology 2005 Feb;102(2) Gottschalk A, Burmeister MA, Radtke P, Krieg M, Farokhzad F, Kreissl S, et al. Continuous Wound infiltration with ropivacaine reduces pain and analgesic requirement after shoulder surgery. Anesth Analg 2003 Oct;97(4):1086-91, Dowling R, Thielmeier K, Ghaly A, Barber D, Boice T, Dine A. Improved pain control after cardiac surgery: results of a randomized, double-blind, clinical trial. J. Thorac. Cardiovasc. Surg. 2003 Nov;126(5):1271-8. 6. Karakaya D, Baris S, Ozkan F, Demircan S, Gok U, Ustun E, et al. Analgesic effects of interpleural bupivacaine with fentanyl for post-thoracotomy pain. J Cardiothorac Vasc Anesth 2004 Aug;18(4):461-5. 7. Beaussier M, El ayoubi H, Schiffer E, Rollin M, Parc Y, Mazoit JX, Azizi L, Gervaz P, Rohr S, Biermann C, Lienhart A, Eledjam JJ. Continuous preperitoneal Infusion of ropivacaine provides effective analgesia and accelerates recovery after colorectal surgery: a randomized, double-blind, placebo-controlled study.

6 Anesthesiology. 2007 Sep;107(3) LeBlanc KA, Bellanger D, Rhynes VK, Hausmann M. Evaluation of Continuous Infusion of bupivacaine by elastomeric pump for Postoperative pain management after open inguinal hernia repair. J Am Coll Surg 2005 Feb;200(2) Fredman B, Shapiro A, Zohar E, Feldman E, Shorer S, Rawal N, et al. The analgesic efficacy of patient-controlled ropivacaine instillation after Cesarean delivery. Anesth Analg 2000 Dec;91(6) D. Thiveaud, V. Demazi res, J. Lafont. Comparison of the performance of four elastomeric devices. EJHP 2005; Baxter data on file (release specifications)12. Baxter data on file (Infusor and catheter testing)13. Baxter data on file (tensile strength testing) Ordering Information*Check with your Baxter representative for local availability SV2 INfusorC170265 hours2 ml/h130mlNameCodeInfusion DurationFlow RateMaximum Fill VolumeLV5 INfusorC100960 hours5 ml/h300mlLV7 INfusorC115643 hours7 ml/h300mlLV10 INfusorC106330 hours10 ml/h300ml Multirate 1,2,3C115443-130 hours1, 2 or 3 ml/h130mlNameCodeInfusion DurationFlow RateMaximum Fill VolumeMultirate 2,3,5C115560-150 hours2, 3 or 5 ml/h300mlMultirate 2,4,6C996050-150 hours2, 4 or 6 ml/h300mlMultirate 5,7,12C996125-60 hours5, 7 or 12 ml/h300mlXLV8 INfusor*C116875 hours8 ml/h600ml INfusors for Continuous Wound InfusionNameCode Fenestrated LengthOverall LengthPAIN fusor Catheter cmPAIN fusor Catheter cmPAIN fusor Catheter cm50 cmPAIN fusor Catheter cm65 cm