Cosmocil CQ antimicrobial – effective use in …

1 COSMETICS AND TOILETRIES MANUFACTURE WORLDWIDE 15 IntroductionAn article outlining the beneficial attributes of CosmocilCQ, and their relevance to the use of Cosmocil CQ in arange of cosmetic and personal care products waspresented in the 2002 issue of Cosmetics and ToiletriesManufacture Worldwide. Cosmocil CQ finds application in products such as: Skin creams and lotions Hair conditioners and shampoos Under-arm deodorants Contact lens cleaning solutions Body and facial wipesThis utilisation of Cosmocil CQ is primarilyunderpinned by its combination of favourable skintoxicology at typical use levels, high order antimicrobialefficacy, and unique physical attributes. This combinationallows product formulators to use Cosmocil CQ forproduct preservation, and further to confer added-valuebenefits such as deodorising and sanitising , Cosmocil CQ has been enjoying expandeduse in the growth product category of impregnated wetwipes for use in skin care products, such as body cleaningand refreshing a result of an increasingly sophisticated consumerdemand for more convenient and effective products, thewipes market has witnessed an explosion of new andinnovative products.

2 Such products are the fastest growingproduct category in the household and personal care sectors,having more than doubled, at the retail level, since 1997, andare predicted to grow at a further 6-7% annually for severalyears(1). Wipes are further seen to be expanding intoadditional market sectors, such as the professional beauty(salon) industry. This in turn, has driven the demand for rawmaterials that offer formulators the means by which toimprove their functionality and effectiveness, with safety inuse being of paramount propertiesThe physical properties of Cosmocil CQ were discussed inthe 2002 issue of CTMW. The key properties of Cosmocil CQ are: Colourless Odourless Formaldehyde-free and solvent-free Water soluble UV stableThese product features, coupled to the polymeric natureof the active ingredient in Cosmocil CQ (polyaminopropylbiguanide, also known as poly(hexamethylene biguanide)hydrochloride, PHMB), result in skin care wipe productsthat do not leave any sticky feel on the skin, or conferundesirable odour or informationPolyaminopropyl biguanide is listed in Annex VI of theEuropean Cosmetic Directive 76/768/EEC relating topreservatives for use in cosmetic products, with amaximum authorised use concentration, as a preservative,of Cosmocil CQ.

3 However, the listing carries a (+)notation, which allows for use at concentrations other thanCosmocil CQ antimicrobial effective use in personal hygiene wipesDr Terry Yeates, Avecia Protection & HygieneCosmocil CQ antimicrobial effective use in personal hygiene wipesCosmocil CQ antimicrobial effective use in personal hygiene wipes16 COSMETICS AND TOILETRIES MANUFACTURE WORLDWIDE those laid down in the Annex for other specific non-preservative uses, which are apparent from thepresentation of the cosmetic the USA, Cosmocil CQ is listed by the CTFA(Cosmetic, Toiletry and Fragrance Association) in itsCosmetic Ingredient (CAS # 27083-27-8) has been notified by Aveciaunder the First Review Regulation 1896/2000 of theEuropean Biocidal Products Directive 98/8 has been accepted for various product typesincluding 01-Human Hygiene Biocidal Products.

4 Cosmocil CQ is supported by an extensive mammaliantoxicology package, which shows it to have low acute toxicityvia dermal and oral routes, low skin and eye irritancypotential at in-use concentrations, and low toxicity followinglong-term of activityThe biocidal efficacy of Cosmocil CQ, in comparison tocommonly used antimicrobials, was discussed in the 2002issue of CTMW. Cosmocil CQis effective against the following broadclasses of organisms: Gram-positive bacteria such as Staphylococcus aureus(including methicillin resistant strains) Gram-negative bacteria such as Pseudomonas aeruginosa Odour causing bacteria such as Staphylococcusepidermidis, Corynebacterium xerosis, and Proteus vulgaris Viruses (naked and enveloped), such as RotavirusThis broad-spectrum activity of Cosmocil CQ supportsits use as both a product preservative, and also as an addedvalue antimicrobial for delivering efficacy claims to thefinished Cosmocil CQ into wet wipesCosmocil CQ is currently utilised in a range of skin contacthygiene wipes.

5 Examples of such include: Freshening alcohol-free body wipes Refreshing and deodorising body wipes Deep cleansing facial wipes Cleaning and disinfecting hand towels containing alcohol Eye cleaning wipes, which also provide mild disinfectionAs with use of any antimicrobial , Cosmocil CQ isseldom used as the sole active ingredient in wet wipeformulations. Outlined in Table 1is an indication of howCosmocil CQ may be co-formulated with additionalantimicrobial agents to provide complementary and widerspectrum activity:* Detailed levels of each component not available. A stabilisedcombination of polyaminopropyl biguanide and iodopropynylbutylcarbamate is available from Schulke & Mayr as EuxylTM K 600,with a recommended use concentration in wet wipes of to above formulation guide involves the use ofantimicrobials commonly used in the cosmetics andpersonal care sector, and indeed forms the basis of theexisting product examples outlined the choice of the antimicrobial package is ofclear importance, so is the choice of additional ingredients,such as surfactants, fragrances etc.

6 Amphoteric surfactantshave been used in the cosmetics industry for many years,and are used in sensitive skin cleansers due to theirfavourable surfactant properties and low skin irritationproperties. Cosmocil CQ has been studied in combinationwith two amphoteric surfactants disodium cocoampho-diacetate and disodium cocoamphodipropionate. Whenused in combination with Cosmocil CQ, both thesesurfactants have been shown to deliver the optimumperformance contribution from the Cosmocil CQFunctionalityIngredientGuide Dose (% w/w in lotion)Preservation against Cosmocil , fungiMethyl against Cosmocil , yeastPotassium fungiCitric against Cosmocil CQ* See belowbacteria, yeastIodopropynyl and fungibutylcarbamateEnhanced skin Cosmocil activityEthyl alcohol10 Eye CareCosmocil 1.

7 Guide co-formulations of Cosmocil CQ in wet wipe liquorCosmocil CQ antimicrobial effective use in personal hygiene wipesCOSMETICS AND TOILETRIES MANUFACTURE WORLDWIDE 17 Cosmocil is a trademark, the property of Avecia references in this article to Cosmocil CQ are referencesto Avecia Protection & Hygiene s Cosmocil CQantimicrobial product. The information and recommendations in this article areto the best of our knowledge, information and belief accurateat the date of publication. Nothing herein is to be construedas a warranty, express or otherwise. In all cases, it is theresponsibility of users to determine the applicability of suchinformation or the suitability of any products for their ownparticular Terry YeatesAvecia Protection & Hygiene Hexagon Box 42 BlackleyManchesterM9 8ZS, UKe-mail.

8 As a guide, when formulating with Cosmocil CQ, these surfactants may be incorporatedat upon the composition of the wipe substrate,desired performance criteria and co-formulation package,the recommended additions of Cosmocil CQ in the wipeliquor range from between and for preservationof the wipe lotion, and between and forconferring a sanitising action to the CQ has been a widely utilised antimicrobial formany years, providing reliable preservation of a diverse rangeof cosmetic and personal care products. With the continuedgrowth in the personal wipes product category, Cosmocil CQis well suited for development of skin contact wipes which canoffer excellent skin mildness and added value performanceattributes. Through judicious choice of both surfactant andco-active package, utilisation of Cosmocil CQ in wet wipelotions can offer enhanced broad activity (1) Nonwovens Industry, October 2003