共用基準範囲対応CTCAE Grade定義表 - jcog.jp

1 CTCAE Grade JCOG Grade 2015/09/10 1 CTCAE Grade 1 Grade 2 Grade 3 Grade 4 JCOG 10002272 Anemia ; ; LLN-100 g/L ; mmol/L; 100-80 g/L g/dL; mmol/L; 80 g/L; ; g/dL g/dL g/dL g/dL g/dL g/dL g/dL g/dL g/dL g/dL Activated partialthromboplastin timeprolonged ULN ULN ULN; - 25-37 sec sec sec sec-10001551 Alanineaminotransferaseincreased ULN ULN ULN ULN 42 U/L 42-126 U/L 126-210 U/L 210-840 U/L 840 U/L 23 U/L 23-69 U/L 69-115 U/L 115-460 U/L 460 U/L10001675 Alkalinephosphatase ULN ULN ULN ULN 322 U/L 322-805 U/L 805-1610 U/L 1610-6440 U/L 6440 U/L10003481 Aspartateaminotransferaseincreased ULN ULN ULN ULN 30 U/L 30-90 U/L 90-150 U/L 150-600 U/L 600 U/L10005364 Blood bilirubin ULN ULN ULN ULN mg/dL mg/dL mg/dL mg/dL 15 mg/dL Cardiac troponin Iincreased I.

2 - - ng/mL-- ng/mL-1000063610007612 JCOG 37 sec Blood and lymphatic system disordersGrade 4 CTCAE Investigations I CTCAE Grade 1 , , I I Grade 1 Grade 3 CTCAE Grade JCOG Grade 2015/09/10 2 CTCAE Grade 1 Grade 2 Grade 3 Grade 4 JCOG Cardiac troponin Tincreased T , , - - ng/mL- ng/mL- CD4 lymphocytesdecreasedCD4 LLN-500 /mm3; 10e9 /L 500-200/mm3; 10e9 /L 200-50/mm3; 10e9 /L 50 /mm3; 10e9 /L 800 /mm3 800-500 /mm3 500-200 /mm3 200-50 /mm3 50 /mm310008661 Cholesterol high ULN-300 mg/dL; mmol/L 300-400 mg/dL; mmol/L 400-500 mg/dL; mmol/L 500 mg/dL; 248 mg/dL 248-300 mg/dL 300-400 mg/dL 400-500 mg/dL 500 mg/dL10011268 CPK increasedCPK ULN ULN-5 ULN 5 ULN-10 ULN 10 ULN 248 U/L 248-620 U/L 620-1240 U/L 1,240-2,480 U/L 2,480 U/L 153 U/L U/L U/L 765-1,530 U/L 1,530 U/L10011368 Creatinine increased ; ULN ; ULN.

3 ULN ULN mg/dL mg/dL mg/dL mg/dL mg/dL mg/dL mg/dL mg/dL mg/dL mg/dL10016596 Fibrinogendecreased LLN 25% LLN 25- 50% LLN 50- 75% LLN 75% 50 180 mg/dL 180-135 mg/dL 135-90 mg/dL 90-45 mg/dL 45 mg/dL10056910 GGT increasedGGT ULN ULN ULN ULN 64 U/L 64-160 U/L 160-320 U/L 320-1,280 U/L 1,280 U/L 32 U/L 32-80 U/L 80-160 U/L 160-640 U/L 640 U/L Haptoglobindecreased LLN--- 19 mg/dL 19 mg/dL---10055599 Hemoglobinincreased ULN 0-2 g/dL ; ULN 0-2 g/dL ULN 2-4g/dL ; ULN 2-4 g/dL ULN 4 g/dL ; ULN 4 g/dL - g/dL g/dL INR increasedINR ULN; ULN; ULN; - Lipase increased ULN ULN ULN ULN 13-53 U/L U/L U/L 106-265 U/L 265 U/L100076131000783910019150 T T ng/mL INR 53 U/L 180mg/dL 19mg/dL CTCAE JCOG CTCAE CD4 CD4 800 /mm3 CTCAE Grade JCOG Grade 2015/09/10 3 CTCAE Grade 1 Grade 2 Grade 3 Grade 4 JCOG Lymphocyte countdecreased LLN-800 /mm3; 10e9 /L 800-500 /mm3; 10e9 /L 500-200 /mm3; 10e9 /L 200 /mm3.

4 10e9 /L 1,000 /mm3 1,000-800 /mm3 800-500 /mm3 500-200 /mm3 200 /mm3 Neutrophil countdecreased LLN-1,500 /mm3; LLN-1 5 10e9 /L 1,500-1,000 /mm3; 1 5-1 0 10e9 /L 1,000-500 /mm3; 1 0-0 5 10e9 /L 500 /mm3; 0 5 10e9 /L 2,000 /mm3 2,000-1,500 /mm3 1,500-1,000 /mm3 1,000-500 /mm3 500 /mm310035528 Platelet countdecreased LLN-75,000 /mm3; 10e9 /L 75,000-50,000 /mm3; 10e9 /L 50,000-25,000 /mm3; 10e9 /L 25,000 /mm3; 10e9 /L 158,000/mm3 158,000-75,000 /mm3 75,000-50,000 /mm3 50,000-25,000 /mm3 25,000 /mm310040139 Serum amylaseincreased ULN ULN ULN ULN 132 U/L 132-198 U/L 198-264 U/L 264-660 U/L 660 U/L10049182 White blood celldecreased LLN-3,000 /mm3; 10e9 /L 3,000-2,000 /mm3; 10e9 /L 2,000 1,000 /mm3; 10e9 /L 1,000 /mm3; 10e9 /L 3,300 /mm3 3,300-3,000 /mm3 3,000-2,000 /mm3 2,000-1,000 /mm3 1,000 /mm3 Acidosis pH.

5 Alkalosis pH . Hypercalcemia mg/dL; mmol/L; mg/dL; mmol/L; ; mg/dL; mmol/L; ; ; mmol/L; ; mg/dL mg/dL mg/dL mg/dL mg/dL10020639 Hyperglycemia ULN-160 mg/dL mmol/L 160-250 mg/dL mmol/L 250-500 mg/dL; mmol/L; 500 mg/dL; ; 109 mg/dL 109-160 mg/dL 160-250 mg/dL 250-500 mg/dL 500 mg/dL10020647 Hyperkalemia mmol/L mmol/L mmol/L; mmol/L; mmol/L mmol/L mmol/L mmol/L mmol/L1000048610001680 Metabolism and nutrition disorders pH JCOG Grade 4 pH JCOG Grade 4 2,000/mm3 1002936610025256 1,000/mm3 CTCAE Grade JCOG Grade 2015/09/10 4 CTCAE Grade 1 Grade 2 Grade 3 Grade 4 JCOG Hypermagnesemia mg/dL; mmol/L- mg/dL; mmol/L mg/dL; ; mg/dL mg/dL- mg/dL mg/dL10020680 Hypernatremia ULN-150 mmol/L 150-155 mmol/L 155-160 mmol/L; 160 mmol/L.

6 145 mmol/L 145-150 mmol/L 150-155 mmol/L 155-160 mmol/L 160 mmol/L10020907 Hyperuricemia ULN-10 mg/dL , - ULN-10 mg/dL , 10 mg/dL; ; mg/dL mg/dL, - mg/dL, 10 mg/dL mg/dL mg/dL, - mg/dL, 10 mg/dL Hypoalbuminemia LLN-3 g/dL; LLN-30 g/L 3-2 g/dL; 30-20 g/L 2 g/dL; 20 g/L ; g/dL g/dL 3-2 g/dL 2 g/dL-10020949 Hypocalcemia mg/dL; mmol/L; mg/dL; mmol/L ; ; mg/dL; mmol/L; ; ; mmol/L; ; mg/dL mg/dL mg/dL mg/dL mg/dL10021005 Hypoglycemia LLN-55 mg/dL; mmol/L 55-40 mg/dL; mmol/L 40-30 mg/dL; mmol/L 30 mg/dL; ; ; 73 mg/dL 73-55 mg/dL 55-40 mg/dL 40-30 mg/dL 30 mg/dL10021018 Hypokalemia mmol/L mmol/L; ; mmol/L; mmol/L; mmol/L mmol/L- mmol/L mmol/L Hypomagnesemia mg/dL; mmol/L mg/dL; mmol/L mg/dL; mmol/L mg/dL; ; mg/dL mg/dL mg/dL mg/dL mg/dL10021038 Hyponatremia LLN-130 mmol/L- 130-120 mmol/L 120 mmol/L; 138 mmol/L 138-130 mmol/L- 130-120 mmol/L 120 mmol/L10021059 Hypophosphatemia mg/dL; mmol/L mg/dL; mmol/L mg/dL; mmol/L mg/dL.

7 Mg/dL mg/dL mg/dL mg/dL mg/dL1002094310020670 10021028 CTCAE Grade 4 JCOG CTCAE Grade 4 CTCAE Grade 2 JCOG CTCAE Grade 2