Cyclo Olefin Polymer(COP) - ZEON

1 Cyclo Olefin polymer (COP). Prototype Production Service for Cyclo Olefin polymer (COP). Molded Products What is Cyclo Ole n polymer (COP)? COP is a thermoplastic polyole n resin with the alicyclic structure in its main chain. Structure and Major Properties of COP. Cat. Cat. H2. ROMP Hydrogenation R1 R2 R1 R2 R1 R2. ROMP = Ring Opening Metathesis Polymerization ZEONEX and ZEONOR are the world's rst COPs exclusively developed by Zeon Corporation. With excellent optical properties, heat resistance, low impurities, and other properties, ZEONEX and ZEONOR are widely used and highly valued in di erent elds, such as optical lenses, medical care, and biotechnology.

2 COP Grades for Biotechnology Applications Properties Unit Measurement ZEONEX ZEONEX ZEONOR ZEONOR ZEONOR . methods 480 5000 1060R 1420R 1430R. Speci c gravity ASTM D792 Water absorbency ASTM D570 23 /24h . Light thickness : 3mm ASTM D1003 92 92 92 92 92. Glass transition JIS K7121 138 68 100 136 133. temperature 9. MFR 280 g/10min ISO1133 20 60 20 30. @230 . Flexural ISO178. Mpa 2100 1900 2100 2200 2200. modulus Tensile Mpa ISO527 59 45 53 61 60. strength Tensile % ISO527 40 120 60 20 16. elongation Data represent experimental results and do not guarantee speci c performance levels under actual usage.

3 For information on the grades for medical equipment and medical packaging, please contact us. ZEONEX and ZEONOR are the registered trademarks of Zeon Corporation. 2. Prototype Production Service We o er prototype production of plastic micro uidic chips using ZEONEX and ZEONOR . Contact us if you have a speci c request. We welcome single unit orders. Examples Sample provided courtesy of Professor Sample provided courtesy of Associate Mizuno, Research Organization for Professor Matsuura, Micro-nano Nano & Life Innovation, Waseda Physiology Course, Department of University Biomedical Engineering, Faculty of Engineering, Okayama University of Science Zeon o ers these services: One-stop support, from molding at plates to cutting microchannels and bonding, at low cost and for quick delivery.

4 Product design recommendations optimized from material perspective. Product design recommendations based on computer-aided design (CAD) engineering and structural analysis. Moderate volume production capability, operating in a Class 10,000 cleanroom. Numerical control (NC) machining 3. Bene ts of COP in Life Science Applications Low uorescence High UV transmittance Little or no interference Highly sensitive of detection detection Low environmental impact High chemical inertness Easy disposal Acid and alkali Alcohol Excellent molding properties Low level of impurities Enable micro uidic Little or no residual channel formation metals Low extracts Low water vapor transmission Low adsorption Maintain stable Compounds concentration Proteins Excellent Properties of ZEONEX and ZEONOR.

5 Low Fluorescence 4000. 3500 Cy3 : Ex/Em=543nm/570nm 3500. Fluorescence intensity ( ). Cy5 : Ex/Em=633nm/670nm 3000. 2500. 2000. 1500 1267. 1000 726. 500 220 250. 38 35 47 39 54 112 59. 0 COP : ZEONEX , Blank COP White glass PC PS black-1 PS black-2 ZEONOR . Fluorescence of Substrate in Cy3 (Ex/Em = 543 nm/570 nm). COP White glass PS PC. Excellent Poor ZEONEX and ZEONOR allow to perform highly sensitive uorescence imaging tests thanks to their low uorescence. 4. High UV Transmittance (Low UV Absorption). 100. 90. 80. Transmittance (%). 70. 60. 50. 40. PC. 30.

6 PMMA. 20 ZEONEX 480. 10. 0. 250 350 450 550 650 750. Wavelength (nm). ZEONEX and ZEONOR have excellent transmittance across the 340 nm 800 nm wavelength spectrum where in vitro diagnostic and sequencing test is commonly used High Chemical Inertness Rate of weight Change in Reagent Condition change appearance 37% HCI RT, 5h None 70% HNO3 50 , 5h None Acid 98% H2SO4 100 , 1h Change into black 30% H2SO4 70 , 5h None HF/HNO3/H2O=7/42/51 RT, 5h 0 None 54% NaOH 50 , 5h 0 None Alkali 29% NH4OH RT, 5h None Other 30% H2O2 RT, 5h 0 None ZEONEX and ZEONOR exhibit excellent resistance to acid, alkali.

7 Alcohol and most aqueous reagents used for life science application. 5. Excellent Properties of ZEONEX and ZEONOR . Low level of impurities Residual metals in COP Out-gassing from Materials 6900. Al V Zr Mg Ti Pd 500. Cr W Fe Ni Zn Cd 400. Out-gassing ng/g (= ppb). Unit: ppm 300. Measured by ICP-MS analysis 190. 200 190. Low 100 outgas Impurity concentration is 0. COP PC PP. below detection threshold. COP : ZEONEX , ZEONOR .. ZEONEX and ZEONOR are extremely pure materials - a very low risk of contamination. Low Adsorption Comparison of Glass and COP BSA Adsorption 4.

8 Glass BSA Adsorption (ug/ ). 3. BSA : Bovine Serum Albumin 2 COP : ZEONEX , ZEONOR . Alkali solution concentration: 1 NaOH at 20 C. Protein adsorption: COP 1 mg/ml BSA solution at 25 C over 0 24 hours 0 10 20 30. Time immersed in alkali solution (days). ZEONEX and ZEONOR are very low in protein adsorption Low non-speci c binding to plastic for PCR application 6. Low Water Vapor Transmission 30. Water vapor permeability (g/ , 24 hours). 25. 20. 15. 10. 5. 0. COP PP LDPE PET PVC PS TPX. Test conditions: COP : ZEONEX , ZEONOR . 100 m lm, 25 C, 90% RH. ZEONEX and ZEONOR provide superior performance for storage stability of reagents and other substances.

9 Excellent Molding Properties Good COP. General- purpose resin COP : ZEONEX , ZEONOR . ZEONEX and ZEONOR make possible the manufacture of high-precision molded products. 7. Important . (1) All the pictures described in this material are examples of potential applications, not necessarily examples of actual use. (2) The figures in this document are typical values and not guaranteed values. These values are for reference only and should not be used as basis for designing of parts. The contents of this document are subject to change without notice. (3) Characteristics of molded products may be influenced by selection of molding material, design of parts, molding conditions, operating environment and so on.

10 It is the responsibility of the customer to evaluate and determine whether the design of the specific material or part is suitable for the application. (4) Please check the responsibility of the customer for industrial property rights owned by a third party. Product Liability Notes 1. Please observe the following precautions for the storage and use of the product and material molded from the product (collectively the Product/Material ). (1) Keep the Product/Material away from fire, as it is combustible. (2) Avoid exposure to direct sunlight and high-energy light, which can discolor the Product/Material.