Transcription of サンジェロース - daido-chem.co.jp
1 C .. 555-0011 4-4-28. TEL 06-6471-7755 FAX 06-6472-2152. URL .. 60L 60M 90L 90M. Hydroxypropyl Methylcellulose Stearoxy Ether .. [C8H7O2(OR)3]n . R=-H R' = - C18H37. - CH3. - [CH2CH(CH3)O]mH. - CH2CH(OH)CH2OR'. HPMC .. 60 90 . 60 .. 90 .. (wt%) .. 60 90 .. HPMC,HEC 1/2 1/3 .. HPMC,HEC .. C .. 60L 60M 90L 90M.. mm2/s 72 108 160 240.. 1 . 2 . 10ppm . 3 .. % . % .. 1 % 2 % 3 % .. 109025.. Y-0025.. 30 . 6 30 . Ames .. 70 1 . 30 . M . - .. 0 10 20 30 40 50 60 70 80 90 100. 60L. L 90L. M 60M. 90M.. wt .. 1% . 60L 45 50 . 90L 55 60 . 0 10 20 30 40 50 60 70 80 90 100.. 100,000. 10,000. m Pa s/ 2 5 .. 1,000 .. 100. 10. 0 1 2. (% ).. pH wt 25 . 100,000. mPa s . 10,000.. pH .. 1,000. 1 2 3 4 5 6 7 8 9 10 11 12 13 14. pH.. wt . 1 0 0 ,0 0 0. mP a s/ 2 5 . 1 0 ,0 0 0. HPMC HEC .. 1 ,0 0 0 . 100. 1 10 100. s - 1 .. NaCL wt 25 . 100,000. mPa s . 10,000 . NaCl .. 1,000. wt% ).. MgSO4 wt 25 . 100,000. mPa s . 10,000 . MgSO4 .. 1,000. wt% .. % 25 . 100,000. 10,000. mPa s .. 1,000 .. 100 .. 10.
2 1% 25 . 100,000. mPa s . 10,000. 1,000.. 100. 0 10 20 30 40 50 60 70 80 90 100.. C . Placental Protein . C .. L- Mg L- Na C .. C C .. 3% Na . 40 4 .. 3% Na 25 . 0 1 2 4 .. 90L. 3,120 3,060 3,140 3,170.. 420nm . 3% C 25 . 0 1 2 4 .. 60L. 1,800 1,780 1,720 2,060.. 90L. 1,720 2,020 1,860 2,060.. 420nm .. O/W Gel Cream . A 1,3- 60L 1% B 6cs Emulium Delta .. HEC HPC.. 1% 20 50 10 40g . 5 . 5 . 5 .. 1% 90L 1% HEC 1% PEG 1% 1% 1% . 5 .. 1% 90L 1% HEC 1% PEG 1% 1% 1% . FRAGRANCE JOURNAL 2007 7 .. M .. C .. ) .. Palliative Care Research 2 227-231 2007 .. MTZ- . MTZ- . MTZ Propylene Glycol JP Sangelose Water for Injection JP . 10mL . 70 90mL . 40 .. min. min.. MTZ-CVP MTZ- MTZ- . 60L 90L . (10-1mm 335 > 400 > 400.. penetrometer 28 Day0,n=5. Diameter (cm). MTZ- 60L . MTZ- 90L . MTZ-CVP . spread meter 1 10 100 1000 mean Time (sec). 28 Day0 n=5.. / .. / .. 0 1 .. Carbopol .. Sangelose .. Franz cell . Donor cell MTZ Preparation . Cellulose membrane area .. Receptor cell Ringer's solution 37.
3 Laboratory Glass Apparatus . 30/32 . Donor cell Receptor solvent . MTZ .. MTZ-CVP . Carbopol MTZ CVP Gel MTZ- . Sangelose MTZ . SW Gel Cumulative amount released 100. 80. 60. of MTZ(%). 40. 20. 0. 0 1 2 3 4 5 6 7 8. Time Time h . (h).
