Transcription of 「薬剤アレルギーにおけるDLST」 - ラジオNIKKEI
1 2010 11 21 T T DLST DLST DLST DLST drug-induced lymphocyte stimulation test DLST LTT (lymphocyte transformation test) in vitro DLST DLST EDTA 10 20mL 96 3 6 12 18 DNA DNA DNA stimulation index (SI) (Cmax)
2 1/10 1 10 DLST DLST DLST T B NK T T B 96 3x105 T T 1000 T IL-2 IL-4 T DNA DLST T T Th1 (Tc1) Th2 (Tc2) Treg Th17 T DLST Th1 Th2 Th1 DLST Th2 Th1 Th2 DLST Th1 Th2 DLST T T regulatory T cell Treg IL-17 Th17 DLST DLST T T (TEN) 61 52 Stevens-Johnson 48 48 (EM) 40 2000.
3 110: 1543-8 (P< ) stimulation index (SI)> acute generalized exanthematous pustulosis (AGEP) TEN - drug-induced hypersensitivity syndrome (DIHS) - TEN DIHS DLST DLST T T DLST - - T - T - T T Th2 Th2 DLST SI Th2 Th1 Th1 T CD30 Th2 T DLST
4 DLST DLST in vitro DLST DLST Treg DLST
