Transcription of 「薬剤アレルギーにおけるDLST」 - ラジオNIKKEI
1 2010 11 21 T T dlst dlst dlst dlst drug-induced lymphocyte stimulation test dlst LTT (lymphocyte transformation test) in vitro dlst dlst EDTA 10 20mL 96 3 6 12 18 DNA DNA DNA stimulation index (SI) (Cmax)
2 1/10 1 10 dlst dlst dlst T B NK T T B 96 3x105 T T 1000 T IL-2 IL-4 T DNA dlst T T Th1 (Tc1) Th2 (Tc2) Treg Th17 T dlst Th1 Th2 Th1 dlst Th2 Th1 Th2 dlst Th1 Th2 dlst T T regulatory T cell Treg IL-17 Th17 dlst dlst T T (TEN) 61 52 Stevens-Johnson 48 48 (EM) 40 2000.
3 110: 1543-8 (P< ) stimulation index (SI)> acute generalized exanthematous pustulosis (AGEP) TEN - drug-induced hypersensitivity syndrome (DIHS) - TEN DIHS dlst dlst T T dlst - - T - T - T T Th2 Th2 dlst SI Th2 Th1 Th1 T CD30 Th2 T dlst dlst dlst in vitro
4 dlst dlst Treg dlst
