Transcription of Drugs Prolonging QT Interval - University of Rochester
1 Drugs Prolonging QT Interval Wojciech Zareba, MD, PhDProfessor of Medicine/CardiologyUniversity of Rochester Medical CenterRochester, NYECG -QT IntervalVentricular Action PotentialNa+IKrCa++IKsLQTS: Genes & ChannelsQT Prolongation & Torsades de Pointes Congenital LQTS Acquired LQTS Drugs Bradycardia Hypokalemia CHF & LVHZ areba W. Cardiology Journal 2007; 14,523 533 Drugs Withdrawn for TdPDrugClassDate WithdrawnTerfenadineAntihistamineFeb 1998 SertindoleAntipsychoticDec 1998 AstemizoleAntihistamineJun 1999 GrepafloxacinAntibioticNov 1999 CisaprideGI ProkineticJuly 2000 Weekeet al. EurHeart J 2019 Weekeet al. EurHeart J 2019 The most common prescriptions used after LQTS diagnosis in 167 patientsAntibiotics 57 (34%)Antidepressants 20 (12%)Antifungals17 (10%)PPI25 (15%)Weekeet al. EurHeart J 2019 European Heart Journal, ehz355, content of this slide may be subject to copyright: please see the slide notes for doctors prescribe a drug with an IKrblocking activity, or any other QT Prolonging action, to patients affected by the long QT syndrome they are in essence presenting them with a potential time bomb which may, or may not explode in a near or distant future.
2 Al. Heart Rhythm J 2019;16:1141-48
