비타민E Vitamin E - kbccc.org

1 E Vitamin E. Natural Standard Monograph, Copyright 2010 ( ).. , .. , .. , .. ( ) .. , .. All rac-alpha-tocopherol, alpha-tocopherol, alpha tocopherol acetate, alpha tocopheryl acetate, alpha tocotrienol, antisterility Vitamin , beta-tocopherol, beta-tocotrienol, d-alpha-tocopherol, d-alpha-tocopheryl, d-alpha-tocopheryl acetate, d-alpha-tocopheryl succinate, d-beta-tocopherol, d-delta-tocopherol, delta- tocopherol, delta-tocotrienol, d-gamma-tocopherol, dl-alpha-tocopherol, dl-alpha-tocopheryl acetate, dl- tocopherol, d-tocopherol, d-tocopheryl acetate, dl-tocopherol, gamma-tocopherol, gamma-tocotrienol, mixed tocopherols, RRR-alpha-tocopherol, Spondyvit , tocopherol, tocotrienol, tocotrienol concentrate, tocopheryl succinate.. E . E 8 (isoforms) . : (alpha), (beta), (gamma), (delta) (tocopherol), , , , (tocotrienol).

2 E E . (alpha-tocopherol equivalents, ATE) . (supplementary labels) (international units, IU) . E . d" . ( , d- - ), dl" ( , dl- - ). E .. E E .. , .. E , .. , warfarin, heparin, aspirin (blood- thining agents) K .. E , E .. E Vitamin E deficiency E , ( , , ) . , , . , ( , A. abetalipoproteinemia), (ataxia) E [AVED]) , , .. E E .. (C ) Hepatitis (hepatitis C). C E C.. E .. Intermittent claudication ( C. ) E .. , .. E . Altitude sickness E . ( , C, , E) C.. High cholesterol E , , . E C. , . ( ) E .. ( ) Healing after photorefractive keratectomy (laser eye surgery). A E C.. E . E .. Amyotrophic lateral sclerosis (ALS). C. ALS E .. Respiratory infection prevention E ( ) , C. E . , . E .. Colon cancer prevention E . A, C, E .. C. E , . (Women's Health Study) . , , E .. Immune system function C. E.

3 Seizure disorder E ( ) C.. Bladder cancer , C. E.. Anemia C. E .. Cataract prevention E .. C. ( 10 ), . E .. ( ) Glomerulosclerosis (kidney disease). ( ) C. (focal segmental glomerulosclerosis) E.. Allergic rhinitis E C. , .. Cancer treatment E .. E . C.. , .. E . E .. Breast cancer E . C. E , , . , . Breast cancer-related hot flashes E C. ( ). E . ( ) . Premenstrual syndrome (PMS). C.. Dysmenorrhea (painful menstruation). C. , . E . Stomach cancer (prevention).. E C.. E .. Prostate cancer prevention C. E .. , .. Venous thromboembolism (VTE). C. E VTE .. Supplementation in preterm and very low birthweight infants E . C. E , ( ), .. , .. , . ( ) Atherosclerosis (clogging and harding of arteries). E (LDL, ) .. E - C.. (the Cambridge Heart Antioxidant Study) . , (Heart Outcomes Prevention Evaluation, HOPE).

4 ( ) Steatohepatitis (inflamed liver). C. , .. ( ) Tardive dyskinesia (involuntary movements) - E , C. , .. E , 5 .. Diabetes mellitus E 1 2 , . , , C. E , , , ( , , ) . E .. / Dementia / Alzheimer's disease C. E , E . ( ) .. all-rac- - ( E) .. selegiline(Eldepryl ) .. selegiline .. donepezil(Aricept ) .. , .. E .. Cardiovascular disease in dialysis patients . ( ) .. C. E .. , E ( ) .. Parkinson's disease C.. ( ) Uveitis (inflammation of the eye). E 4 - C.. Antioxidant E C.. , , . E . ( ) Chemotherapy nerve damage (neurotoxicity). E .. E (cisplatin) .. C.. , .. ( ) Angina (chest pain). , E C.. C. G6PD G6PD deficiency E G6PD .. ( ) Macular degeneration (eye disease)- E , .. E C.. - C . , E .. Osteoarthritis D. E . E . Stroke E D.. E . Rheumatoid arthritis D. E .. Retinitis pigmentosa E . , . D.

5 E .. Heart disease prevention E .. E . ( ) .. E D. (10 ).. , E . , E .. Cancer prevention (general). D. ( ) . E .. E , , . , .. E . E . Asthma D. E . Peyronie's disease E, propionyl-L-carnitine D. (PD) , , (plaque) . Scar prevention D. E .. / . , .. , .. , , ( ), , , , amiodarone pulmonary . , , , - , ( ) , . / ( , , , , , . , ( ), , , , , . , / , , , , , , , , ( E), , , ( ), , , , , , , ( ), , , , , , , , , , , , , , , , , , ( ), ( . ), , , , , , , , , ( ), .. , . , .. , E . E . E .. E ( ) .. , , .. ( ) . , . E . E . E . E (tolerable upper intake level(UL)) . E .. , E E.. E , , , . ( ). E . (necrotizing enterocolitis) . E . E K- . ( K ). E . , .. (Coumadin ) .. all-rac-alpha-tocopherol ( E) .. , . E , , , ( . ). E .. E . E .. , E .. , .. E .. , (Coumadin ) , clopidogrel (Plavix ) . , (Motrin , Advil ) naproxen (Naprosyn , Aleve ).)

6 ( , , ) .. , , .. Cholestyramine (Questran ), colestipol (Colestid ), orlistat (Xenical ), isoniazid (INH, Lanizid , Nydrazid ), olestra (Olean fat substitute), sucralfate (Carafate ) . E E .. Gemfibrozil (Lopid ) -, - . henobarbital, phenytoin, carbamazepine E . E , - .. E, tocopheryl succinate polyethylene glycol ( ). E - .. E ( ) .. , Ginkgo biloba . , . E - . E . E .. -6 E .. E A , , A .. E A . E E .. E .. ( ) .. 1. Bairati I, Meyer F, Jobin E, et al. Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients. Int J Cancer 2006 Nov 1;119(9):2221-4. 2. Bjelakovic G, Nikolova D, Simonetti RG, et al. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev 2008 Jul 16;(3):CD004183. 3. Boshtam M, Rafiei M, Golshadi ID, et al.

7 Long term effects of oral Vitamin E supplement in type II diabetic patients. Int J Vitam Nutr Res 2005 Sep;75(5):341-6. 4. Fillenbaum GG, Kuchibhatla MN, Hanlon JT, et al. Dementia and Alzheimer's disease in community- dwelling elders taking Vitamin C and/or Vitamin E. Ann Pharmacother 2005 Dec;39(12):2009-14. 5. Gao J, Gao X, Li W, et al. Observational studies on the effect of dietary antioxidants on asthma: a meta- analysis. Respirology 2008 Jun;13(4):528-36. 6. Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 2009 Jan 7;301(1):52-62. 7. Isaac MG, Quinn R, Tabet N. Vitamin E for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2008 Jul 16;(3):CD002854.

8 8. Karlson EW, Shadick NA, Cook NR, et al. Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study. Arthritis Rheum 2008 Nov 15;59(11):1589-95. 9. Lin J, Cook NR, Albert C, et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009 Jan 7;101(1):14-23. 10. Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005 Jul 6;294(1):56-65. 11. Mayer-Davis EJ, Nichols M, Liese AD, et al. Dietary intake among youth with diabetes: the SEARCH for Diabetes in Youth Study. J Am Diet Assoc 2006 May;106(5):689-97. 12. Orrell RW, Lane RJ, Ross M. A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease.

9 Amyotroph Lateral Scler 2008 Aug;9(4):195-211. 13. Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA 2008 Nov 12;300(18):2123-33. 14. Walsh PC. Effects of long-term Vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. J Urol 2005 Nov;174(5):1823-4. 15. Wluka AE, Stuckey S, Brand C, et al. Supplementary Vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J Rheumatol 2002;29(12):2585-2591. 16. You WC, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006 Jul 19;98(14):974-83.

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