Easy begins here. COBAS Portfolio of Real-Time …

1 Easy begins Portfolio of Real-Time PCR SystemsEasy-to-operate systems provide walk-away technology that delivers reliable begins COBAS Portfolio of Real-Time PCR Systems* The COBAS AmpliPrep/ COBAS TaqMan CMV Test is not available in the United technology that delivers reliable results Automated primary tube handling Ready-to-use bar-coded reagent cassettes minimize manual preparation and errors Single-room operation consolidates routine testing Modular/flexible system optimizes space and workflow Contamination controls ensure sample and data integrity Advanced test performance Refined primer/probe chemistry improves specificity, sensitivity.

2 And dynamic ranges Enhanced genotype/subtype inclusivity improves patient managementStart-to-finish capabilities Largest PCR manufacturing facility from research to in-house manufacturingLocally-based field service offers excellent customer and product support One call gives you direct access to a world class support organization Our technical support hotlines provide immediate access to local support teams backed by global expertsRoche is the global leader in molecular diagnostics and has developed the only Real-Time PCR system that unites primary tube handling with fully automated sample preparation, amplification and detection of RNA or DNA.

3 The easy-to-operate system provides high throughput processing for a menu of important molecular tests including HIV, HCV, HBV, and CMV*. The system improves workflow efficiencies in your laboratory and reduces hands-on Systems SupportOur Global Systems Support organization of more than 2,000 technical and field experts serves Roche customers in more than 70 fully automated solution For simplified, molecular testingThe only fully automated, Real-Time PCR system that unites primary tube handling and sample preparation with amplification, quantification and detection of RNA or begins COBAS p 630 Instrument/ COBAS AmpliPrep/ COBAS TaqMan SystemImportant advantages of the Roche integrated sample processing and detection system High throughput capacity: Run a total of 168 samples within an 8 hour shift or overnight with the docked system for continuous operation Task flexibility: 4 independent, onboard thermal cyclers allow up to 4 assays to run simultaneously Advanced assay performance: Excellent sensitivity, specificity, and broad linear range to minimize the need for repeat testing or dilutions Integrity of results.

4 AmpErase enzyme and a closed-tube format optimizes contamination control Quantitation standards and internal controls are used throughout the entire process, from sample preparation to amplification, quantification and detection, to deliver reliable and accurate results Dependable self-monitoring operation: Clot detection and input-volume-surveillance ensure dependable results Ready-to-use reagents with self-sealing caps and bar-coded sample tracking ensure reagent consistency and simplifies workflowcobas p 630 Instrument Complements the system: Automates pre-analytics and Real-Time PCR diagnostic testing for a menu of important molecular testsUnique docking station streamlines workflow, maximizes productivity Prepared samples transfer automatically from the COBAS AmpliPrep Instrument to the COBAS TaqMan Analyzer Enables continuous operation with no manual sample transferThis automated system increases laboratory capability and productivity from sample preparation to Real-Time amplification, quantification and detection.

5 The easy-to-operate system delivers reliable test results and reduces overall begins AmpliPrep/ COBAS TaqMan 48 SystemSimple to use, easy to integrate Fast results: Two independent thermocylers allows detection/amplification of DNA or RNA for up to 2 assays simultaneously Flexible lab productivity: Two independent thermal cyclers provide 48-sample capacity Advanced assay performance: Real-Time PCR technology provides broad dynamic ranges, excellent sensitivity and specificity Enhances workflow: No user interaction required after prepared samples are loaded. The system provides PCR set-up and no post-PCR manipulations Reduces contamination risk: Closed-tube format and AmpErase enzyme reduce cross-reactivity and minimize testing errorsThis semi-automated, closed-tube system makes molecular testing practical for everyday lab use.

6 The system incorporates the COBAS TaqMan 48 Analyzer, which has a compact begins High Pure System Viral Nucleic Acid KitThe High Pure System Viral Nucleic Acid Kit Designed: Purification of viral nucleic acids from EDTA plasma or serum Purification procedure: Filler tubes allow for multiple samples to be processed in parallel Specimen input: 500 uL of EDTA plasma or serum Kit size: 48 sample preparation Sample preparation for TaqMan 48 Analyzer: Each single sample preparation can be used with the COBAS TaqMan HIV, HCV, and HBV Tests Closed-tube processing and built-in Roche AmpErase enzymeThe High Pure System Viral Nucleic Acid Kit along with the COBAS TaqMan 48 Analyzer empowers laboratories to provide physicians and their patients access to the convenience of Real-Time PCR with the innovation you expect from can select among the Portfolio the configuration that is suitable for their individual workflow and throughput begins flexibility and customizable solutions Result integrity and data security Sample tracking from start-to-finish reduces errors and saves time Automatic archiving and backup of data Flexibility

7 And simplicity Offers the flexibility of integrated sample processing and detection systems with multiple system manage-ment, including system maintenance and sample and reagent level Reagent lot tracking allowing kits to be used for multiple runs Easy-to-use graphical user interface Easy-to-read display of system and sample status Customized reports Software guides through maintenance procedures Connectivity Capability for bidirectional interfacing to laboratory information systems COBAS p 630 Instrument can link to and support up to three COBAS AmpliPrep Instruments One COBAS AmpliPrep Instrument supports any combination of three COBAS TaqMan Analyzers or COBAS TaqMan 48 AnalyzersAMPLILINK Software user interface is a

8 Windows -based application that manages operation and maintenance of the complete system. AMPLILINK Software is designed to deliver maximum flexibility, efficiency and integrity to your lab s workflow from sample input through results ClientLaboratory Info System (LIS) COBAS TaqMan 48 AnalyzerCOBAS TaqMan AnalyzerCOBAS AmpliPrep Instrument (up to 3)AMPLILINK Servercobas p 630 Data StationAMPLILINK Clientcobas p 630 InstrumentGlobal Surveillance Program for better diagnostics, prognostics, and disease management Integral part of Roche Molecular Diagnostics product development: including research and development, regulatory submission, and post-launch support* Input from the program has improved the design and development of products Roche continues to broaden its own database: currently expanding sample acquisition in Europe, South America, Africa and Asia Facilitates epidemiological investigations: helps to identify trends responsible for the spread of infection, builds on current collaborations and the pursuit of new ones* These products are not available in all countries.

9 Please contact the Roche Diagnostics representative in your country. Young KKY, Roche Viral Surveillance Program. Data on files, Roche Molecular s Global Surveillance Program is designed to make a positive, lasting impression on the field of molecular diagnostics in many ways. Roche s Global Surveillance Program monitors viral sequence changes and supports continuous improvement of PCR assays. Available in the United States as research use only. These products are not available in all countries. Please contact the Roche Diagnostics representative in your Catalog NumberCOBAS TaqMan 48 Analyzer 03279332001 COBAS TaqMan Analyzer 03121453001 COBAS AmpliPrep Docking Station 28127387001 COBAS AmpliPrep Instrument 03051315001cobas p 630 Instrument 05527503001 COBAS AmpliPrep/ COBAS TaqMan HBV Test (CE-IVD) 03587819190 COBAS AmpliPrep/ COBAS TaqMan HBV Test, (CE-IVD) 04894570190 COBAS AmpliPrep/ COBAS TaqMan HBV Test, (FDA-IVD) 05027012190 COBAS AmpliPrep/ COBAS TaqMan HIV Qual RUO 05035724190 COBAS AmpliPrep/ COBAS TaqMan HIV-1 Test (FDA-IVD)

10 03542998190 COBAS AmpliPrep/ COBAS TaqMan HIV-1 Test, (CE-IVD) 05212294190 COBAS AmpliPrep/ COBAS TaqMan HIV-1 Test, (FDA-IVD) 05212308190 COBAS AmpliPrep/ COBAS TaqMan HCV Test (CE-IVD) 03568547190 COBAS AmpliPrep/ COBAS TaqMan HCV Test (FDA-IVD) 03568555190 COBAS AmpliPrep/ COBAS TaqMan CMV Test (CE-IVD) 04902068190 COBAS TaqMan HIV-1 Test, v2. For use with the High Pure System (CE-IVD) 05923468190 COBAS TaqMan HBV Test For use with the High Pure System (CE-IVD) 03500756190 COBAS TaqMan HBV Test For use with the High Pure System (FDA-IVD) 03577163190 COBAS TaqMan HCV Test, For use with the High Pure System (CE-IVD) 04861817190 COBAS TaqMan HCV Test, For use with the High Pure System (FDA-IVD) 05989060190 COBAS TaqMan MTB Test (CE-IVD) 04803531190 COBAS TaqMan