新型コロナウイルスのウイルス学的特徴 - Eiken

1 Virology of SARS-CoV-2 Up-to-date2 11 66 11 2020 Up-to-date 313 321-0293 880 Department of MicrobiologyDokkyo Medical University School of Medicine(Kita-kobayashi 880, Mibu, Tochigi, 321-0293 Japan) 12 12 WHO 1 2 1, 2 2003 SARS SARS 2 SARS-CoV-2 WHO SARS-CoV-2 coronavirus disease 19 COVID-19 3 9 25 3,000 100 80,000 1,500 SARS MERS SARS -CoV-2 SARS I. ICTV 4 1 4 229E3 OC434 NL635 HKU16 4 NL43 HKU1 21 4 SARS 7 2002 10 SARS Michiaki M ASUDA 12 314 MERS 8 2012 MERS 35 2015 7

2 SARS 2 SARS MERS II. 1 100 nm RNA N N N S E M 30,000 RNA RNA 30,000 RNA 5 RNA 3 S E M N 2 PCR 1 229E3 1966 APN127 NL635 2004 ACE226 OC434 1967 O- 28 SARS 7 2003 SARS ACE223 HKU16 2005 O- 29 MERS 8 2012 MERS DPP430 SARS -21, 2 2020 COVID-19 ACE210 1 13 315 N III.

3 3 9 S mRNA RNA RNA RNA RNA RNA RNA RNA RNA mRNA 3 S E M N RNA E M 2 3 Alanagreh, L et al., Pathogens, 2020 ; 9 5 , 331. 9 14 316 E 7 1 SARS angiotensin-converting enzyme 2 ACE2 10 ACE2 ACE2 11 ACE2 S TMPRSS2 SARS S 12 TMPRSS2 S

4 RNA RNA RNA RNA RNA RdRp RNA 1 1 2 DNA 100 RNA 13 RdRp RNA ExoN RNA 30,000 RdRp RNA ExoN RdRp RNA IV. RNA D614G 14 S 614 D 2 G D614G 3 D614G 15 317 3 4 15 14 S ACE2 D614G S ACE2 ACE2 D614G D614G 20 D614G 2 D614G D614G D614G

5 COVID-19 7 16 6 6 1 2 6 PCR V. 2 3 2 COVID-19 9 23 3 1 2 ARDS 3 1 2 16 318 3 COVID-19 D D 17 COVID-19 18 20 DIC DIC D

6 D ACE2 ACE2 4 11 ACE2 D 21, 22 ACE2 1 SARS ACE2 23 SARS 8,000 8 800 24 NL63 ACE2 25 SARS NL63 S ACE2 26 NL63 4 17 319 5 1 Wu F, Zhao S, Yu B, et al.

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