話題の感染症 非定型抗酸菌と非 ... - eiken.co.jp

1 52 3 2006 57.. Atypical Mycobacteria and Atypical Mycobacteriosis . 1 1 2 . Yukio MORITA Masahiro FUJITA Soichi MARUYAMA. M. laprae . M. avium subsp. paratuberculosis . AM AM. Atypical Mycobacteria : AM .. 55 . AM M. avium 1967 Runyon M. tuberculosis . complex MAC MAC M. avium M. M. bovis anonymous intracellulare M. avium 4 mycobacteria . avium hominissuis silvaticum . paratuberculosis . MAC AIDS . MAC Mycobacteria other avium than tubercule bacilli : MOTT Non-Tuber- hominissuis culous mycobacteria : NTM . AM 1986 Bergey's Manual of System- 75 . atic Bacteriology Bargey's Manual . AM 54 . MAC 4 M. tuberculosis M. bovis M. africanum M. MAC microti M. laprae M. avium subsp. paratu- berculosis 48 AM DNA . 2, 57 .. 20, 21, 24, 32, 46, 63, 74 21 . AM PCR rpoB . 20 . hsp65 .. Atypical Mycobacteria : AM 1 rpoB . Mycobacterium tuberculosis complex M. rpoB Gen- tuberculosis M. bovis M. africanum M. microti M.

2 Bank . canettii 99% . 1 1 Gunma Prefectural Institute of Public Health and Environmental Sciences 0371- 0052 378 (378, Kamioki, Maebashi, Gunma). 2 2 Laboratory of Veterinary Public Health, Nihon University 0252- 8501 1866 (1866, Kameino, Fujisawa, Kanagawa). 1 . 58. 21 . Mycobacterial Infection . National Center for Biotechnology Information . AM .. 150 2006 1 31 . AM AM . AM AM . 3, 31, 56, 69, 75 . Non Tuberculous . R. equi AF057494 . C. diphtheriae AF057496 . N. nova AF057495 . M. chitae AF057461 . M. thermoresistibile AF057489 . M. fallax AF057462 . M. flavescens AF057463 . M. abscessus AF057449 . M. chelonae AF057460 . M. fortuitum 49403 AF057465 . Rapidly growing M. fortuitum AF057464 . Mycobacteria M. phlei AF057480 . M. aurum AF057456 . M. vaccae AF057492 . M. senegalense AF057483 . M. smegmatis AF057485 . M. neoaurum AF057477 . M. peregrinum AF057481 . M. intracellulare AF057472 . M. szulgai AF057487.

3 M. asiaticum AF057455 . M. gordonae AF057468 . M. intermedium AF057471 . M. triviale AF057490 . M. nonchromogenicum AF057478 . M. terrae AF057488 . M. interjectum AF057470 . M. scrofulaceum AF057482 . M. avium AF057457 . M. paratuberculosis AF057479 . M. celatum Type1 AF057458 . M. celatum Type2 AF057459 Slowly growing M. genavense AF057467 Mycobacteria M. simiae AF057484 . M. shimoidei AF057486 . M. marinum AF057476 . M. ulcerans AF057491 . M. kansasii AF057473 . M. xenopi AF057493 . M. gastri AF057466 . M. malmoense AF057475 . M. haemophilum AF057469 . M. leprae AF057474 . M. tuberculosisH37Rv AF057454 . M. bovis BCG AF057452 . M. africanum AF057450 . M. bovis AF057451 . Diversity 1 rpoB N-J . GenBank accession no Rodococcus equi, Corinebacterium diphtheriae Nocardia nova . outgroup DNA Data Bank of Japan ClustalW TreeView . 2 . 59. MAC .. M. kansasii M. gordonae M. flavescens M. chelonae 43.

4 5. AM AM 1g 10 . 35 . 1 2 AM . AM AM . 43, 66 43, 71 . MAC M. scrofulaceum M. nonchro- . 66 67 . mogenicum M. terrae MAC . M. intracellulare M. scrofulaceum . 71 71 . M. scrofulaceum . M. intracellulare . MAC. M. intracellulare . MAC . 3, 9 11, 25, 26 . M. intracellulare M. scrofulaceum . 13, 14, 23, 50 53, 73, 78 53 . M. avium . 1 . a .. 1965 M. avium M. nonchromogenicum 66 . 1967 M. terrae 67 . 1974 M. scrofulaceum 71 . M. intracellulare M. scrofulaceum 1997 MAC M. scrofulaceum M. nonchromogenicum 43 . MAC 12 M. gordonae . 1968 M. intracellulare 78 . 1976 M. intracellulare M. scrofulaceum 13 . 1979 M. scrofulaceum M. terrae M. intracellulare 14 . M. nonchromogenicum M. gordonae M. scrofulaceum M. gordonae M. intracellulare M. scrofulaceum M. intracellulare 2 4 M. gordonae M. intracellulare M. scrofulaceum M. terrae 1983 M. intracellulare M. scrofulaceum 50 . 1971 M. intracellulare 7, 12, 14, 18, 19 52.

5 M. scrofulaceum 43 . 1974 M. intracellulare M. scrofulaceum 51 . 1980 M. intracellulare M. scrofulaceum 73 . 1980 M. avium M. intracellulare 53 . M. intracellulare 8 . 1977 Runyon group 31 . 1974 M. kansasii M. xenopi 29 . 1973 M. intracellulare 4 8 23 . 2002 M. gordonae 7 . AM M. gordonae M. fortuitum AM MAC 2 9 Mycobacterium spp. 2003 M. avim subsp. hominissuis M. abscessus M. scrofulaceum M. gastri 9 . 2004 M. avim subsp. hominissuis 11 . 2005 M. avim subsp. hominissuis 25 . 2004 M. avim subsp. hominissuis 6, 8 M. fortuitum 26 . a M. intracellulare MAC . 3 . 60. 2 43 . Runyon . 55 . n 240 n 240 n 240 n 240 n 960 . a . M. kansasii 1 4 5. M. gordonae 2 3 5. MAC b 2 13 15. M. nonchromogenicum 3 3. M. gastri 2 2. 1 1 2. M. flavescens 1 3 4. M. chelonae 1 2 1 4. M. thermoresistivile 1 1. M. obuence 1 1. 1 2 6 10. 4 5 10 33 52. a . b MAC M. avium complex 4 1 6 1 . 4 2 6 1 8 4 6 . M. intracellulare.

6 M. avium complex MAC 22 24 26 28 . 2, 56, 57 .. 1 . Anz Intermediate . 55 . AM Runyon M. avium Authentic M. M. avium complex MAC intracellulare . M. kansasii M. marinum Heat Shock M. scrofulaceum Protein dnaJ . 75 . MAC Bergey's Manual M. avium M. 1 6 8 11 21. intracellulare M. avium 7 12 20 22 28 . 75, 77 . M. intracellulare M. avium M. intracellulare . 6 39 . 2 . MAC . 30 . MAC MAC . 3 1960 . 60, 61 . Schaefer MAC M. avium M. avium subsp. avium M. Bergey's Manual M. avium M. intracellulare avium subsp. hominissuis M. avium subsp. silvaticum 1 3 M. avium subsp. paratuberculosis 4 . 32 . M. avium 4 28 M. intracellulare avium 1 3 . 75, 77 1 . 1970 Anz MAC IS901 IS1245 . hominissuis 4 . Avium Intermediate Authentic 3 6 8 11 21 IS1245 . 1980 M. avium M.. intracellulare DNA probes silvaticum paratuberculosis . M. avium M. intracellulare . 4 6 8 11 21 Middlebrook 7H10 . M. avium 7 12 20 25 silvaticum IS901.

7 4 . 61. 3 M. avium complex . IS901 IS1245 a .. DNA 16 -23S rDNA internally transcribed . spacer region . Schaefer 60, 61 Wolinsky and Schaefer 77 . Anz 1 1970 57 . 1983 Roth 54 . 2000 Mijs 32 . 2002 . 1965 1968 1979 .. Avium M. avium 1 M. avium M. avium subsp. avium Avium M. avium 2 M. avium M. avium subsp. avium Avium M. avium 3 M. avium M. avium subsp. avium Intermediate M. intracellulare 4 M. avium M. avium subsp. hominissuis Intermediate M. intracellulare 5 M. avium M. avium subsp. hominissuis Intermediate M. intracellulare 6 M. avium M. avium subsp. hominissuis Authentic M. intracellulare 7 M. intracellulare M. intracellulare Davis Intermediate M. intracellulare 8 M. avium M. avium subsp. hominissuis Watson Intermediate M. intracellulare 9 M. avium M. avium subsp. hominissuis a Intermediate M. intracellulare 10 M. avium M. avium subsp. hominissuis b Intermediate M. intracellulare 11 M. avium M.

8 Avium subsp. hominissuis Howell M. intracellulare 12 M. intracellulare M. intracellulare Chance M. intracellulare 13 M. intracellulare M. intracellulare Boone Authentic M. intracellulare 14 M. intracellulare M. intracellulare Dent M. intracellulare 15 M. intracellulare M. intracellulare Yandle Authentic M. intracellulare 16 M. intracellulare M. intracellulare Wilson M. intracellulare 17 M. intracellulare M. intracellulare Altman Authentic M. intracellulare 18 M. intracellulare M. intracellulare Darden Authentic M. intracellulare 19 M. intracellulare M. intracellulare Arnold Authentic M. intracellulare 20 M. intracellulare M. intracellulare M. intracellulare 21 M. avium M. avium subsp. hominissuis M. intracellulare 22 M. intracellulare Brockett M. intracellulare 23 M. intracellulare M. intracellulare 24 M. intracellulare M. intracellulare 25 M. intracellulare M. intracellulare Cox M. intracellulare 26 M.

9 Intracellulare Harrison M. intracellulare 27 M. intracellulare M. intracellulare 28 M. intracellulare a subsp. avium IS901 IS1245 subsp. hominissuis IS1245 . M. intracellulare IS901 IS1245 .. Serotypes 25, 27. Serotype 26. Serotype 12. Serotype 19. Serotype 13. Cluster . Serotypes 15, 23, 24. Serotypes 14, 16, 17, 20. Serotype 18, 28. Serotype 7. Serotype 22. Serotypes 5, 6, 8, 10, 21. Serotypes 1,11 Cluster . Serotypes 2, 3, 4, 9. Diversity 2 M. avium complex dnaJ N-J . GenBank accession no AB097876 AB097903 . 5 . 62. avium . paratuberculosis IS900 . M. intracellulare 7 12 . 20 22 28 IS901 IS1245 . 32 . MAC .. Schaefer .. MAC .. 1 . M. marinum .. 2 3 2 .. AM .. AM . 3, 7, 12, 17 . AM M. marinum Swimming- 65 22 . pool granuloma fish-tank granuloma .. 68, 72 .. AM MAC M.. kansasii 1 2 3 .. AM AM . 49 .. 56 .. AIDS AM . MAC . MAC . 17 . AIDS MAC .. 17, 56 3, 26 . AIDS . AM AM MAC . 69 3, 34, 36, 42.

10 AIDS MAC . M. kansasii M. scrofulaceum 1969 AM . 3, 7, 77 34 . AIDS 50 60% . 12, 16, 17, 28 . MAC AM . MAC HIV 1979. 912,093 55 . 6 . 63. 4, 7, 24, 27, 28, 46, 52, 60, 61 . AM . 36, 42 . MAC. AM . M A C 8 9 4 AIDS MAC . hominissuis 1 2 3 . avium 1 3 9 AIDS AIDS . 18, 41, 42, 70 . MAC . 31, 60, 61 3, 4, 5, 15, 28 . avium . 44 25 . AM MAC . avium hominissuis . MAC AIDS .. avium . MAC .. 19, 37, 40 . AM . 37 .. AIDS . M. avium . 19 . AM . AM . 3, 19 . MAC MAC . 37, 40, 59 64 38 45, 47, 58 33 . AM . 40, 59 .. 37 . AM M. avium subsp. paratuberculosis .. 45 . M. avium . 33, 58 8 . M. kansasii .. 48 . No Visible Lesion Reactor . 76 62 . M. simiae M. avium M. avium subsp. paratuberculosis . 49 . M. marinum . AM . AM .. AM MAC 1 Anz, W., et al.: Vergleich von sensitin-testen an meer- schweinchen mit serotyp und huhnervirulenz bei M. avium-und M. intracellulare-stammen, Zentrabl. Bakteri- MAC . ol. Parasistenkd.