Emerging Treatment Options for the Reversal of …

1 Emerging Treatment Options for the Reversal of oral anticoagulant therapy Presented as a Midday Symposium at the 47th ASHP Midyear Clinical Meeting and Exhibition Monday, December 3, 2012 Las Vegas, Nevada Remind Me Tool Planned and conducted by ASHP Advantage and supported by an educational grant from CSL Behring Please be advised that this activity is being audio and/or video recorded for archival purposes and, in some cases, for repurposing of the content for enduring materials. 2 Emerging Treatment Options for the Reversal of oral anticoagulant therapy AGENDA 11:30 11:40 Welcome and Introductions Edith A.

2 Nutescu, , FCCP 11:40 12:00 oral anticoagulant Therapies: A Balancing Act Edith A. Nutescu, , FCCP 12:00 12:40 Options for Reversing the Effects of oral Anticoagulants James S. Kalus, , BCPS (AQ-Cardiology) 12:40 1:10 Practical Issues in Developing an oral anticoagulant Reversal Strategy William E. Dager, , BCPS (AQ-Cardiology) 1:10 1:30 Faculty Discussion and Audience Questions All Faculty FACULTY Edith A. Nutescu, , FCCP Activity Chair and Moderator Clinical Professor The University of Illinois at Chicago College of Pharmacy Director, Antithrombosis Center The University of Illinois Hospital and Health Sciences System Chicago, Illinois James S.

3 Kalus, , BCPS (AQ-Cardiology) Senior Manager, Patient Care Services Department of Pharmacy Services Henry Ford Hospital Detroit, Michigan William E. Dager, , BCPS (AQ-Cardiology) Pharmacist Specialist UC Davis Medical Center Sacramento, California 3 Emerging Treatment Options for the Reversal of oral anticoagulant therapy DISCLOSURE STATEMENT In accordance with the Accreditation Council for continuing Medical education s Standards for Commercial Support and the Accreditation Council for Pharmacy education s Guidelines for Standards for Commercial Support, ASHP Advantage requires that all individuals involved in the development of activity content disclose their relevant financial relationships.

4 A person has a relevant financial relationship if the individual or his or her spouse/partner has a financial relationship ( , employee, consultant, research grant recipient, speakers bureau, or stockholder) in any amount occurring in the last 12 months with a commercial interest whose products or services may be discussed in the educational activity content over which the individual has control. The existence of these relationships is provided for the information of participants and should not be assumed to have an adverse impact on presentations.

5 All faculty and planners for ASHP Advantage education activities are qualified and selected by ASHP Advantage and required to disclose any relevant financial relationships with commercial interests. ASHP Advantage identifies and resolves conflicts of interest prior to an individual s participation in development of content for an educational activity. The faculty and planners report the following relationships: Edith A. Nutescu, , FCCP, Activity Chair Dr. Nutescu declares that she has has served as a consultant for Daiichi-Sankyo Inc.

6 And received a research grant and served as a consultant for Janssen Pharmaceuticals, Inc. James S. Kalus, , BCPS (AQ-Cardiology) Dr. Kalus declares that he has no relationships pertinent to this activity. William E. Dager, , BCPS (AQ-Cardiology) Dr. Dager declares that he has no relationships pertinent to this activity. Susan R. Dombrowski, , Ms. Dombrowski declares that she has no relationships pertinent to this activity. Carla J. Brink, , Ms. Brink declares that she has no relationships pertinent to this activity. ASHP staff has no relevant financial relationships to Treatment Options for the Reversal of oral anticoagulant therapy ACTIVITY OVERVIEW As the armamentarium of oral agents for prevention and Treatment of thrombosis expands, practitioners must develop strategies to deal with the proper management of anticoagulant -related bleeding complications.

7 Patients on oral anticoagulants who are at high risk of bleeding, are actively bleeding, or require emergency invasive procedures will need adjunct therapies that reverse or remove anticoagulant effects sooner than withholding the drug. This activity will provide an overview of the challenges associated with oral anticoagulant therapies, including risks for developing bleeding complications. Therapeutic Options for reversing the effects of oral anticoagulants will be described, focusing on new and Emerging Options for Reversal . Using different patient scenarios, the faculty will explore practical issues in developing a Reversal strategy for oral anticoagulant therapy .

8 ACTIVITY OBJECTIVES After attending this application-based educational activity, participants should be able to Identify risk factors for bleeding complications with oral anticoagulant agents. Apply strategies for minimizing the risk of bleeding with oral anticoagulant agents. Describe the relative benefits and limitations of emergent anticoagulant Reversal strategies. Discuss the clinical evidence supporting the use of emergent anticoagulant Reversal strategies. Explain patient-specific Treatment Options for reversing the effects of oral anticoagulants using laboratory observations.

9 Develop an approach to managing major bleeding in a patient on oral anticoagulation therapy . 5 Emerging Treatment Options for the Reversal of oral anticoagulant therapy continuing education ACCREDITATION The American Society of Health-System Pharmacists is accredited by the Accreditation Council for Pharmacy education as a provider of continuing pharmacy education . This activity provides hours ( CEUs) of continuing pharmacy education credit (ACPE activity #0204-0000-12-438-L01-P). Attendees must complete a continuing Pharmacy education Request online and may immediately print their official statements of continuing pharmacy education credit at the ASHP CE Center at following the activity.

10 Complete instructions for receiving your statement of continuing pharmacy education online are on the next page. Be sure to record the session code beginning with A announced during the activity. New! PRACTICE REMINDER EMAIL During this educational activity, we encourage you to jot down points about what YOU want to remember to do as a result of what you are learning. Use your smart device to link directly to the reminder tool and type in your ideas. Next month, we will send you an email as a reminder from YOURSELF about what YOU want to do after attending this activity.