Essential Clinical Immunology - SACEMA

1 Essential Clinical ImmunologyThe ways in which we can better understand cancer, HIV, and other autoimmune diseases through Clinical Immunology are of great interest to all scientists, from students to post-graduate practitioners. Designed as an introduction to science students (MD, MD PhD, PhD) as well as to more advanced PhDs and medical practitioners, this book focuses on the importance of immunological concepts in disease states. Essential Clinical Immunology begins with the basic concepts and then details the immuno-logical aspects of various disease states involving major organs of the body.

2 The book explores how we can better understand disease and its treatment through Clinical Immunology . Looking forward, each chapter concludes with patterns for future research. John B. Zabriskie ( , Columbia College of Physicians and Surgeons) is Professor Emeritus and former head of the Laboratory of Clinical Micro-biology and Immunology at The Rockefeller University, New York, New York. He has written numerous articles on Immunology , micro biology, and Clinical ImmunologyEdited byJohn B. ZabriskieThe Rockefeller UniversityCAMBRIDGE UNIVERSITY PRESSC ambridge, New York, Melbourne, Madrid, Cape Town, Singapore, S o PauloCambridge University PressThe Edinburgh Building, Cambridge CB2 8RU, UKFirst published in print formatISBN-13 978-0-521-51681-5 ISBN-13 978-0-521-70489-2 ISBN-13 978-0-511-46529-1 Cambridge University Press 20092008 Information on this title: publication is in copyright.

3 Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any partmay take place without the written permission of Cambridge University University Press has no responsibility for the persistence or accuracy of urls for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or in the United States of America by Cambridge University Press, New (NetLibrary)hardbackList of Contributors vii 1 Basic Components of the Immune System 1 John B. Zabriskie, 2 Immunological Techniques 21 John B. Zabriskie, 3 Immune Regulation 33 Nina Bhardwaj, , , David O Neill, , and Thomas Waldmann, 4 Immunological Aspects of Infection 45 Kumar Visvanathan, , , Christopher M.

4 MacIsaac, , ,William W. Hall, , , and Vincent A. Fischetti, 5 Immunological Aspects of Immunodefi ciency Diseases 61 Dinakantha S. Kumararatne, 6 Autoimmunity 91 Haoyang Zhuang, , Matthew Kosboth, , Jennifer A. Sipos, , Minoru Satoh, , , Lijun Yang, , and Westley H. Reeves, 7 Chronic Lymphocytic Leukemia 119 Nicholas Chiorazzi, , and Manlio Ferrarini, 8 Immunology of HIV Infections 131 Anders G. Vahlne, , 9 Immunological Aspects of allergy and Anaphylaxis 145 Paul M. Ehrlich, , and Jonathan D. Field, , 10 Immunological Aspects of Skin Diseases 163 James G. Krueger, , , and Lisa Zaba, , vContentsvi Contents 11 Experimental Approaches to the Study of Autoimmune Rheumatic Diseases 175 Dalit Ashany, , and Mary K.

5 Crow, 12 Immunological Aspects of Cardiac Disease 199 John B. Zabriskie, , Allan Gibofsky, , , Wesley C. Van Voorhis, , , Frederick S. Buckner, , and Noel R. Rose, , 13 Immunological Aspects of Chest Diseases: The Case of Tuberculosis 231 Ernesto Mu oz-El as, , and Robert J. Wilkinson, , FRCP 14 Immunological Aspects of Gastrointestinal and Liver Disease 251 Christine Moung, , and Lloyd Mayer, 15 Immunological Aspects of Endocrine Disease 277 Jean-Fran ois Bach, 16 Immune-Mediated Neurological Syndromes 293 Jacqueline Friedman, 17 Immunological Aspects of Renal Disease 313 Gil Cu, , and John B. Zabriskie, 18 Immunological Aspects of Transplantation 331 Jeffrey M.

6 Venstrom, , and James W. Young, 349 Dalit Ashany, Attending Physician, Hospital for Special SurgeryAssistant Professor of Medicine, Weill Medical College of Cornell UniversityHospital for Special SurgeryNew York, NY Jean-Fran ois Bach, of Immunology , Necker Hospital, ParisSecr taire perp tuelAcad mie des sciencesParis, France Nina Bhardwaj, , of Tumor Vaccine CenterNew York Cancer InstituteNew York, NY Frederick S. Buckner, ProfessorDepartment of Medicine, Division of Infectious DiseasesUniversity of WashingtonSeattle, WA Nicholas Chiorazzi, and Director, Laboratory of Experimental ImmunologyFeinstein Institute for Medical ResearchManhasset, NY Mary K.

7 Crow, ScientistDepartment of RheumatologyHospital for Special SurgeryNew York, NY Gil Cu, Professor and Medical DirectorDepartment of Medicine, Division of Nephrology and HypertensionUniversity of Florida, JacksonvilleJacksonville, FL Paul M. Ehrlich, Assistant Professor Department of PediatricsNew York University School of MedicineNew York, NY Manlio Ferrarini, Nazionale per La Ricerca sul Cancro, ISTG enova, Italy Jonathan D. Field, , , pediatric allergy and Immunology Clinic New York University/Bellevue Medical CenterNew York, NY Vincent A. Fischetti, , Laboratory of Bacterial PathogenesisRockefeller UniversityNew York, NY viiContributors Jacqueline Friedman, ProfessorDepartment of NeurologyNew York Harbor VA Medical CenterNew York, NY Allan Gibofsky, of Medicine and Public HealthWeill Medical College of Cornell UniversityNew York, NY William W.

8 Hall, , of Medical MicrobiologyUniversity College DublinDublin, Ireland Matthew Kosboth, FellowDivision of Rheumatology and Clinical ImmunologyUniversity of FloridaGainesville, FL James G. Krueger, , DirectorRockefeller UniversityNew York, NY Dinakantha S. Kumararatne, in ImmunologyDepartment of Clinical Biochemistry and ImmunologyAddenbrooke s HospitalCambridge, UK Christopher M. MacIsaac, , CandidateCentre for Infl ammatory DiseasesMonash Institute of Medical ResearchClayton, Victoria, Australia Lloyd Mayer, and Chairman, Immunobiology CenterDorothy and David Merksamer Professor of MedicineChief, Division of Clinical ImmunologyChief, Division of GastroenterologyMount Sinai Medical CenterNew York, NY Christine Moung, of PathologyMount Sinai Medical CenterNew York, NY Ernesto Mu oz-El as, FellowDepartment of MicrobiologyTufts UniversityBoston, MA David O Neill, Professor of PathologyDirector, NYUCI Vaccine and Cell Therapy Core FacilityNew York University School of MedicineNew York, NY Westley H.

9 Reeves, Whitney Schott Professor of MedicineDivision of Rheumatology and Clinical ImmunologyUniversity of FloridaGainesville, FL Noel R. Rose, , of PathologyProfessor of Molecular Microbiology and ImmunologyDirector, Johns Hopkins Center for Autoimmune Disease Research Bloomberg School of Public HealthBaltimore, MDviii Contributors Minoru Satoh, , ProfessorDivision of Rheumatology and Clinical ImmunologyUniversity of FloridaGainesville, FL Jennifer A. Sipos, Assistant ProfessorDivision of EndocrinologyUniversity of FloridaGainesville, FL Anders G. Vahlne, , of Clinical Virology Department of Immunology , Microbiology, Pathology, and Infectious DiseasesKarolinska University Hospital, HuddingeStockholm, Sweden Jeffrey M.

10 Venstrom, , Hematology-Medical OncologyDepartment of MedicineMemorial Sloan-Kettering Cancer CenterNew York, NY Kumar Visvanathan, , , Innate Immunity Laboratory and Infectious Diseases PhysicianCentre for Infl ammatory DiseasesDepartment of Medicine (Monash Medical Centre)Monash UniversityClayton, Victoria, Australia Wesley C. Van Voorhis, , Program Director, Infectious DiseasesProfessor of MedicineAdjunct Professor of PathobiologyUniversity of WashingtonSeattle, WA Thomas Waldmann, , Cytokine Immunology and Immunotherapy SectionMetabolism Branch ChiefCenter for Cancer Research, National Cancer InstituteNational Institutes of HealthWashington, DC Robert J.