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FAO PLANT PRODUCTION AND PROTECTION …

FAOPLANTPRODUCTIONAND PROTECTIONPAPER200 ISSN 0259-2517200 Pesticide residues in food 2010 Joint FAO/WHO Meeting on Pesticide Residues FAOP esticide residuesin food 2010 REPORT2010 Joint FAO/WHO Meeting on Pesticide ResiduesFood and Agriculture Organization of the United Nations9 789251067352I1949E/1 978-92-5-106735-2 ISSN 0259-2517 The annual Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues was held in Rome, Italy, from 21 to 30 September 2010. The FAO Panel of Experts had met in Preparatory Sessions from 16 to 20 September. The Meeting was held in pursuance of recommendations made by previous meetings and accepted by the governing bodies of FAO and WHO that studies should be undertaken jointly by experts to evaluate possible hazards to humans arising from the occurrence of pesticide residues in foods.

FAO PLANT PRODUCTION AND PROTECTION PAPER 200 ISSN 0259-2517 200 Pesticide residues in food 2010 – Joint FAO/WHO Meeting on Pesticide Residues FAO Pesticide residues

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Transcription of FAO PLANT PRODUCTION AND PROTECTION …

1 FAOPLANTPRODUCTIONAND PROTECTIONPAPER200 ISSN 0259-2517200 Pesticide residues in food 2010 Joint FAO/WHO Meeting on Pesticide Residues FAOP esticide residuesin food 2010 REPORT2010 Joint FAO/WHO Meeting on Pesticide ResiduesFood and Agriculture Organization of the United Nations9 789251067352I1949E/1 978-92-5-106735-2 ISSN 0259-2517 The annual Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues was held in Rome, Italy, from 21 to 30 September 2010. The FAO Panel of Experts had met in Preparatory Sessions from 16 to 20 September. The Meeting was held in pursuance of recommendations made by previous meetings and accepted by the governing bodies of FAO and WHO that studies should be undertaken jointly by experts to evaluate possible hazards to humans arising from the occurrence of pesticide residues in foods.

2 During the meeting the FAO Panel of Experts was responsible for reviewing pesticide use patterns (use of good agricultural practices), data on the chemistry and composition of the pesticides and methods of analysis for pesticide residues and for estimating the maximum residue levels that might occur as a result of the use of the pesticides according to good agricultural practices. The WHO Core Assessment Group was responsible for reviewing toxicological and related data and for estimating, where possible and appropriate, acceptable daily intakes (ADIs) and acute reference doses (ARfDs) of the pesticides for humans. This report contains information on ADIs, ARfDs, maximum residue levels, and general principles for the evaluation of pesticides. The recommendations of the Joint Meeting, including further research and information, are proposed for use by Member governments of the respective agencies and other interested HEALTH ORGANIZATIONFOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONSRome, 2011 Pesticide residues in food 2010 Joint FAO/WHO Meetingon Pesticide Residues FAOPLANT PRODUCTIONAND PROTECTIONPAPERR eport of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and theWHO Core Assessment Group on Pesticide ResiduesRome, Italy.

3 21 30 September 2010 200 The designations employed and the presentation of material in this information product do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations (FAO) concerning the legal or development status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed or recommended by FAO in preference to others of a similar nature that are not views expressed in this information product are those of the author(s) and do not necessarily reflect the views of FAO. ISBN 978-92-5-106735-2 All rights reserved.

4 FAO encourages reproduction and dissemination of material in this information product. Non-commercial uses will be authorized free of charge, upon request. Reproduction for resale or other commercial purposes, including educational purposes, may incur fees. Applications for permission to reproduce or disseminate FAO copyright materials, and all other queries concerning rights and licences, should be addressed by e-mail to or to the Chief, Publishing Policy and Support Branch, Office of Knowledge Exchange, Research and Extension, FAO, Viale delle Terme di Caracalla, 00153 Rome, Italy. FAO 2011 CONTENTS List of participants .. i 2010 Joint FAO/WHO Meeting on Pesticide Residues .. i Abbreviations .. v Use of JMPR reports and evaluations by registration authorities .. ix 1. Introduction.

5 1 Declaration of interests .. 2 2. General considerations .. 3 Consideration regarding JMPR capacity and resources .. 3 Dietary risk assessments conducted by the JMPR: need for appropriate consumption data for further method development .. 6 The needs of JMPR concerning food consumption data: Update on the activities of the GEMS/Food programme .. 7 Information on the use of pesticides required for the estimation of residue levels in minor crops .. 8 Principles and guidance on the selection of representative crops for the extrapolation of MRLs .. 11 Statistical calculation of MRLs .. 12 Appropriate value from replicate samples from a supervised field trial for use in statistical calculation of the MRL estimate .. 13 The application of proportionality in selecting data for MRL estimation.

6 14 Further consideration of expert judgement in evaluating residue trials .. 17 Use of the OECD Feed table .. 18 Training of scientists from developing countries for the establishment of pesticide maximum residue levels in foods and assessment of the risk from dietary intake of residues .. 20 3. Responses to specific concerns raised by the Codex Committee on Pesticide Residues (CCPR) .. 21 Bifenthrin (178) (T) .. 21 Cypermethrin (118) (R) .. 21 Fluopicolide (235) (T) .. 22 Paraquat (057) (R) .. 24 4. Dietary risk assessment .. 27 5. Evaluation of data for acceptable daily intake and acute dietary intake for humans, maximum residue levels and supervised triALS median residue values .. 31 Bifenazate (219) (R).

7 31 Bifenthrin (178) (R)** .. 37 Boscalid (221) (R) .. 55 Cadusafos (174) (R)** .. 61 Chlorantraniliprole (230) (R) .. 67 Chlorothalonil (081) and metaboliteS R611965 and SDS-3701(T, R)** .. 77 Clothianidin (238) (T, R)* .. 107 Cyproconazole (239) (T, R)* .. 149 Dicamba (240) (T, R)* .. 171 Difenoconazole (224) (R) .. 195 Dithianon (180) (T)** .. 201 Endosulfan (032) (R) .. 207 Etoxazole (241) (T, R)* .. 209 Fenpyroximate (193) (R).. 227 Flubendiamide (242) (T, R)* .. 235 Fludioxonil (211) (R) .. 259 Fluopyram (243) (T, R)* .. 263 Meptyldinocap (244) (T, R)* .. 283 Novaluron (217) (R) .. 295 Spices (R) .. 303 Tebuconazole (189) (T)** .. 307 Thiamethoxam (245) (T, R)* .. 313 Triazophos (143) (R) .. 365 6. Recommendations .. 367 7. Future work .. 369 Annex 1: Acceptable daily intakes, short-term dietary intakes, acute reference doses, recommended maximum residue limits and supervised trials median residue values recorded by the 2010 Meeting.

8 373 Annex 2: Index of reports and evaluations of pesticides by the JMPR .. 391 Annex 3: International estimated daily intakes of pesticide residues .. 403 Annex 4: International estimates of short-term dietary intakes of pesticide residues .. 463 Annex 5: Reports and other documents resulting from previous Joint Meetings of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO core assessment group on pesticide residues .. 529 Annex 6: Livestock dietary burden .. 537 Corrigenda Corrections to the report of the 2009 Meeting .. 571 D, dietary risk assessment; R, residue and analytical aspects; T, toxicological evaluation. * New compound ** Evaluated within the periodic review programme of the Codex Committee on Pesticide Residues i LIST OF PARTICIPANTS 2010 JOINT FAO/WHO MEETING ON PESTICIDE RESIDUES ROME, 21 30 SEPTEMBER 2010 FAO Members Dr Ursula Banasiak, Federal Institute for Risk Assessment, Thielallee 88-92, D-14195 Berlin, Germany Mr Stephen Funk, Health Effects Division (7509P), United States Environmental PROTECTION Agency, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA Mr Denis J.

9 Hamilton, Principal Scientific Officer Biosecurity, Department of Primary Industries and Fisheries, PO Box 46, Brisbane, QLD 4001, Australia Mr David Lunn, Senior Programme Manager (Residues plants ), Export Standards Group, New Zealand Food Safety Authority, PO Box 2835, Wellington, New Zealand (FAO Rapporteur) Dr Dougal MacLachlan, Australian Quarantine and Inspection Service, Australian Government Department of Agriculture, Fisheries and Forestry, GPO Box 858, Canberra, ACT 2601, Australia Dr Bernadette Ossendorp, Centre for Substances and Integrated Risk Assessment, National Institute of Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, Netherlands (FAO Chairman) Dr Yukiko Yamada, Deputy Director-General, Food Safety and Consumer Affairs Bureau, Ministry of Agriculture, Forestry and Fisheries, 1-2-1 Kasumigaseki, Chiyoda-ku, Tokyo 100-8950, Japan WHO Members Professor Alan R.

10 Boobis, Experimental Medicine & Toxicology, Division of Investigative Science, Faculty of Medicine, Imperial College London, Hammersmith Campus, Ducane Road, London W12 0NN, England Dr Les Davies, Chemical Review, Australian Pesticides and Veterinary Medicines Authority, Kingston ACT, Australia ii Dr Vicki L. Dellarco, Office of Pesticide Programs (7501P), United States Environmental PROTECTION Agency, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA (WHO Rapporteur) Professor Angelo Moretto, Department of Environmental and Occupational Health, University of Milan, International Centre for Pesticides and Health Risk Prevention, Luigi Sacco Hospital, Via Stephenson 94, 20157 Milan, Italy (WHO Chairman) Dr Roland Solecki, Chemical Safety Division, Steering of Procedures and Overall Assessment, Federal Institute for Risk Assessment, Thielallee 88-92, D-14195 Berlin, Germany Dr Maria Tasheva, Consultant, National Service for PLANT PROTECTION , Ministry of Agriculture and Food, 17 Hristo Botev Bul.


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