FibroScan 을 이용한 간탄력도 검사 - ekjm.org

1 : 74 5 2008- 463 - (Review) FibroScan , . Liver stiffness measurement using FibroScan Kwang-Hyub Han, and Seung Up Kim, of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;Liver Cirrhosis Clinical Research Center, Seoul, KoreaProgressive liver fibrosis is a similar feature of all chronic liver diseases and eventually develops liver cirrhosis. The prognosis and treatment plans of chronic liver diseases depend strongly on the degree of liver fibrosis.

2 These facts raise clinical interests in quantifying liver fibrosis. Although liver biopsy has been the gold standard for assessment of liver fibrosis, it has some technical limitations and risks. Accordingly, an increasing need for alternative non-invasive method to quantify liver fibrosis has been a major challenge that has stimulated search for new non-invasive methods. Such methods for diagnosing liver fibrosis have progressed significantly over the last few years notably with the appearance of several serological markers which have been reported to predict the presence of significant fibrosis or cirrhosis in patients with chronic liver disease with considerable accuracy.

3 However, complicated calculation, cost problems, and influences of extrahepatic conditions make it less accessible to clinicians. Recently, liver stiffness measurement using FibroScan is emerging as a new diagnostic method for liver fibrosis. It is totally non-invasive and reproducible and gives an immediate result without intra- and inter-observer variability. Its clinical use in comparison with liver biopsy and several available serologic markers is now intensively being investigated.

4 Here, we review the currently available data on FibroScan . (Korean J Med 74:463-471, 2008) Ke y Words : Liver fibrosis; Liver cirrhosis; Liver stiffness; FibroScan ; Transient elastography*The authors equally contributed to this work. 1). , 2-4).. 5, 6).. The Korean Journal of Medicine : Vol.

5 74, No. 5, 2008 - 464 - .. 7-9). , aspartate amino-transferase (AST), alanine aminotransferase (ALT), , , , . FibroScan . FibroScan , Transient elastography , Liver stiffness Medline.

6 1. (stiffness) (fibrosis) (elasticity) 10). kilopascal (kPa) . (transducer) .. , , 5 , , , 1/500 10).2. 2.

7 ( 6 cm ) . 3 cm2 . 10 .. 10 .3. C B . Ziol 11) 251 C Metavir .. The area of receiver operating characteristic curve (AUROC) F2 (significnat fibrosis) , F3 (advanced fibrosis) , F4(cirrhosis) kPa, kPa, kPa.

8 Foucher 12) 711 (C 398 , B 43 ) (r= ). AUROC F2 , F3 , F4 . Ganne-Carrie 13) 1,007 F4 AUROC kPs 74%, 94% . 228 B . kPa, kPa, kPa, kPa, kPa Kwang-Hyub Han, et al : Liver stiffness measurement using FibroScan - 465 - 14). AUROC ( 1).

9 4. (Human immunodefici-ency virus, HIV) De L dinghen 15) HIV C 72 (Kendall t-b= ; p< ). AST/ALT ratio, aspartate aminotransferase to platelet ratio index (APRI) AUROC . Vergara 16) HIV C 169 . Barreiro 17) HIV C 283 3 C , , ALT.

10 Castellares 18) 2,168 HIV 12kPa , . Maida 19) HIV C AST, ALT HCV-RNA , F3 25% .5.. Colleta 20) 40 C FibroTest FibroTest . Castera 21) FibroTest APRI C 183 , FibroTest . Coco 22) F2 APRI, Forns index, FibroTest , F4 APRI, hyaluronic acid, FibroTest.