Transcription of G-11571 057206 速流通 R 持續釋放膠囊 …
1 G-11571 057206 RTamsulosin Capsules mg CYH B62 (2) ( tamsulosin HCl ) 1. mg tamsulosin HCl 7 8 1) Cmax AUC 7 4 2) < > (mg) Tmax ( Cmax(ng/mL) ( 11 mg 2 1- AGP( 1 1- AGP 1- AGP 3) 2. mg 30 12 14% 2) 2) 4 ) 5 ,6 ) 309 mg 1 1 7) mg1 1 (15/53) mg1 1 (85/199) mg1 1 (22/57) < > 1. 1 Prazosin HC1 Phentolamine mesilate 40 8) 2.
2 (1) 9,10) 1 Prazosin HC1 1 22 Phentolamine mesilate 45 140 1 2 5,400 24,000 (2) 11~13) 1 Prazosin HC1 23 98 Phentolamine mesilate 8 320 1 13 (3) 14) the prostatic zone of the intraurethral pressure) < > 2 tamsulosin hydrochloride ( )-(R)-5-2- 2-(o -ethoxyphenoxy)ethyl - amino propyl -2- methoxybenzenesulfonamide hydrochloride C2 0H2 8N2O5S HCl 230 C( ) tamsulosin hydrochloride Formic acid ethanol ether (25 C ) 2 ~ 1000 A tamsulosin Hydrochloride Each Capsule contains tamsulosin Hydrochloride mg ( ) 1 1 tamsulosin Hydrochloride mg mg mg mg mg mg 1.
3 ( ) tamsulosin 2. (1) 1, tamsulosin tamsulosin (2) ( mg) (3) ( <10 mL/min) (4) tamsulosin (Intraoperative Floppy Iris Syndrome IFIS ) tamsulosin 1-2 tamsulosin tamsulosin (5) tamsulosin CYP3A4 CYP2D6 CYP3A4 ketoconazole) (6) (7) (8) 3. ( ) Vardenafil HC1 (Levitra) Vardenafil HC1 ( ) Sildenafil Citrate Sildenafil Citrate 4.
4 4,724 104 ) (1) 1) 2) ( ) AST(GOT) ALT(GPT) (2) ~5% (>1/1000 <1/100) ( ) (>1/1000 <1/100) ) 5. (1) PTP PTP ( PTP ) Size 180mm( ) A
