国立がんセンター中央病院 薬剤 ... - ganjoho.jp

1 2008.. 19 TodayToday s Contentss Contents National Cancer Center Hospital36 1,074 435 40 270 24 600 06012018024030036042048030 stayHOSP stayNETwaitALLwaitLABwaitDRwaitPHARM (2006)(2006) 186 (184 ) 125 (131 ) 135 (145 ) 40 (33 ) 65 (65 ) 34 (52 )

2 2005 4 9 regimen A treatment planthat specifies thedosage, the schedule, and the duration An action plan for a clinical trial. The plan states what the study will do, how, and why. It explains how many people will be in it, who is eligible to participate, what study agents or other interventions they will be given, what tests they will receive and how often, and what information will be gathered.

3 National Cancer Institute NCI CPT-11 CDDP CPT-11 70mg/m2 day1, day15 CDDP 80mg/m2 day1 4 day1day1 80mg/m80mg/m22 CDDPCDDP 70mg/m70mg/m22 Dana-Farber 1994 11 g/m2/ 280mg 280mg 15 9 15 9

4 14 4 12 10 mg 50mg 12 6 120mg 11 11 12 10 11 32 2 21 2 5 32 66%91%0%20%40%60%80%100% 15 12 18 1 69 38 52 20 24 10 10 33 12 1 10 7 5 1 10 10 315

5 18 33 0246 27 53 80 5 5 5 4 4 3 3 3 2 1 1 0510 1 7 7 2 9 7 5 7 5 1 2 050100150200250300350400 14 10 15 4 15 10 16 4 16 10 17 6 17 10 18 5 263378254292251 TS-1 11 16 UFT-E TS-1 9 14 TS-1 S-1 FT CDHP Oxo1 15-FU DPD 5-FU )NOHClHOHNNFOOOHNNHNOCOOHO++ Dr.

6 28 FU UFTCap Cap Cap 5-FU 28 7 Dr. or TS-1 Dr. 50mg/ 60mg/ 75mg/ 40mg/ 50mg/ 60mg/ 40mg/ 40mg/ 50mg/ EBM National Institutes of Health Cancer Institute Clinical Practice Guidelines Breast Cancer Gastrointestinal Cancer Genitourinary Cancer Head and Neck Cancer Hematologic Malignancies Lung Cancer Supportive Care and Quality of PS 0 2

7 III FOLFOX infusional 5-FU/l-LV oxaliplatin FOLFIRI infusional 5-FU/l-LV irinotecan) IFL 5-FU/l-LV* irinotecan 5-FU/l-LV* de Gramont sLV5FU2 AIO RPMI UFT/LV 2005 FOLFOX FOLFOX FOLFOX FOLFIRI FOLFOX 17 16 10 FOLFIRI/FOLFOX

8 85mg/m2 FOLFOX/FOLFIRI 1 2 2 (Hand-foot syndrome) Hand-Foot Syndrome HFS) DLF ) 0100200300400500600700

9 100mg 11 55 2020 50mL50mL 55 250250 500mL500mL LV5150mL 50 100mL11:155ml/h 2400mg/m25FU 250mg/5mL511:15 400mg/m25FU 250mg/5mL4250mL 250mL9:15120 1 85mg/m 100mg3500mL 500mL9:15120 200mg/m2 25mg2100mL 50mL8mg 8mg/2mL9.

10 0030 1A 3mg/3mL1day 1 NomFOLFOX 1 FOLFOXFOLFOX L OHP 250mL/2hrl-LV 500mL/2hr mFOLFOX L-OHP l-LV 90901001001000204060801001 3 5 10 60 180 32 10 2006 LV5150mL 50 100mL11:155ml/h 2400mg/m25FU 250mg/5mL511:15 400mg/m25FU 250mg/5mL4250mL 250mL9:15120 1 85mg/m 100mg3500mL 500mL9:15120 200mg/m2 25mg2100mL 50mL8mg 8mg/2mL9.