神経病理観察の留意点 - geocities.jp

1 1 1. 1 2. 3. 4. 5. 6. 1 7. 1. 1 2. 3. 4. 5. 6. 1 7. 1 --- central chromatolysis, inflated neuron2 --- neurofibrillary tangle (NFT), Lewy body, Pick body, Lafora body, Hirano body, Bunina body, eosinophilic inclusion granules, Marinesco body3 --- vacuolar degeneration, granulovascular degeneration4 --- laminar necrosis5 --- atrophy, sclerosis6 --- neuronal loss1 --- central chromatolysis, inflated neuron2 --- neurofibrillary tangle (NFT)

2 , Lewy body, Pick body, Lafora body, Hirano body, Bunina body, eosinophilic inclusion granules, Marinesco body3 --- vacuolar degeneration, granulovascular degeneration4 --- laminar necrosis5 --- atrophy, sclerosis6 --- neuronal loss* 1 2 * 1 2 3 4 Waller * 1 2 * 1 2 3 4 Waller * neuropil1 spongy state 2 senile plaque 3 Kuru plaque *glia1 astroglia, astrocyte ----swelling, hypertrophy,, proliferation, gliosis, bnormal glia, corpora amylacea, Rosenthal fibe2 oligodendroglia3 microglia* neuropil1 spongy state 2 senile plaque 3 Kuru plaque *glia1 astroglia, astrocyte ----swelling, hypertrophy,, proliferation, gliosis, bnormal glia, corpora amylacea, Rosenthal fibe2 oligodendroglia3 microglia staining technique staining technique hematoxylin-eosin (HE) staining Kl ver-Barrera (KB) staining Bodian impregnation Holzer staining immunohistochemistry hematoxylin-eosin (HE) staining Kl ver-Barrera (KB)

3 Staining Bodian impregnation Holzer staining immunohistochemistry2 cytology cytology neuron myelin & axon neuropil glia astrocyte, astroglia oligodendrocyte, oligodendroglia microglia neuron myelin & axon neuropil glia astrocyte, astroglia oligodendrocyte, oligodendroglia microglia dementia dementia Alzheimer s disease neurofibrillary tangle (NFT) twisted tubules paired helical filament (PHF) senile plaque Pick's disease Pick body Alzheimer s disease neurofibrillary tangle (NFT) twisted tubules paired helical filament (PHF) senile plaque Pick's disease Pick body Parkinson s disease, paralysis agitans Lewy body depigmentation of the substantia nigra multiple system atrophy (MSA) atrophy of the pons, inferior olive , cerebellum glial cytoplasmic inclusion(GCI) Parkinson s disease, paralysis agitans Lewy body depigmentation of the substantia nigra multiple system atrophy (MSA) atrophy of the pons, inferior olive , cerebellum glial cytoplasmic inclusion(GCI) progressive supranuclear palsy (PSP) neurofibrillary tangle (NFT) straight tubules atrophy of the brainstem tegmentum amyotrophic lateral sclerosis (ALS)

4 Bunina body motor neuron death progressive supranuclear palsy (PSP) neurofibrillary tangle (NFT) straight tubules atrophy of the brainstem tegmentum amyotrophic lateral sclerosis (ALS) Bunina body motor neuron death multiple sclerosis (MS) demyelination acute disseminated encephalomyelitis (ADEM) progressive multifocal leukoencephalopathy (PML) Jcvirus oligodendroglia gemistcytic astrocyte multiple sclerosis (MS) demyelination acute disseminated encephalomyelitis (ADEM) progressive multifocal leukoencephalopathy (PML) Jcvirus oligodendroglia gemistcytic astrocyte prion disease prion disease Creutzfeldt-Jakob disease (CJD) spongiform change gemstocytic astrocyte prion plaque Creutzfeldt-Jakob disease (CJD) spongiform change gemstocytic astrocyte prion plaque3 infection infection subacute sclerosing panencephalitis (SSPE) intranuclear inclusion progressive multifocal leukoencephalopathy oligodendroglia astroglia oligodendrocyte subacute sclerosing panencephalitis (SSPE)

5 Intranuclear inclusion progressive multifocal leukoencephalopathy oligodendroglia astroglia oligodendrocyte alcoholism alcoholic cerebellar atrophyWernicke Wernicke s encephalopathy Vitamin B1(Thiamine) 3 astrocyte, macropharge alcoholism alcoholic cerebellar atrophyWernicke Wernicke s encephalopathy Vitamin B1(Thiamine) 3 astrocyte, macropharge neurotoxicology neurotoxicology arsenic poisoning acute hemorrhagic leukoencephalitis arsenic poisoning acute hemorrhagic leukoencephalitis 10 trauma11 hypoxia12 vascular disease13 malformation14 perinatal disorder15 schizophrenia16 epilepsy 17 peripheral nerve disease18 muscle disease 19 tumor10 trauma11 hypoxia12 vascular disease13 malformation14 perinatal disorder15 schizophrenia16 epilepsy 17 peripheral nerve disease18 muscle disease 19 tumor45

6 CerebrumCerebrumCerebrumCerebrummidbrain midbrainponsponsmedullamedulla6cerebellu mcerebellumAstrocyteAstrocyteOligodendro cyteOligodendrocyteMicrogliaMicroglia7 Crebral cortexCrebral cortexSpinal cordSpinal cordcerebellumcerebellum89101112131415