소독제의 종류와 특성 - gie.or.kr

1 The Korean Journal of Gastrointestinal Endoscopy Room C Vol. 43 (Suppl 2), 2011 (167-169)167 Characteristics of Endoscopic DisinfectantsJoong-Hyun Lee, of Internal Medicine, Dongguk University Medical School, Gyeongju, Korea .. , . (semicritical) (high-level disinfection) , (autoclave) (ethylene oxid) . 180 1.

2 1. glutaraldehyde 2. ortho-phtahldehyde3. peracetic acid Hydrogen peroxide 4. Electrolyzed Acid Water5. FDA isopropanol , , hydrogen peroxide peracetic acid , hypochlorous acid/hypochlorite , . 1. glutaraldehyde(GA) , . 2% glutaraldehyde 14 .. Glutaraldehyde , . 20 25oC 20 ( 10 20 , mycobacteria 20 45 , 6 10 ), aldehyde.

3 35% . 80% .. glutaraldehyde , , . , . Cidex Widex . Cidex 1 L g 168 The Korean Journal of Gastrointestinal Endoscopy . Widex 2% ( , 3 ) 5 L 15 g pH . glutaradehyde 26% isopro-panol Aldahol Healthpoint LTD .2. ortho-phtahldehyde (OPA) glutaraldehyde.

4 5 ( 12 , 5 ) . OPA . PH (3 9) . (2 ) . , , , .. Cidex-OPA .3. peracetic acid (PAA) Hydrogen peroxide Peracetic acid Hydrogen peroxide peracetic acid ( 7%) hydero-gen peroxide (1 ) . 5 .Peracetic acid 56 . pH.

5 PH 3 . , , . pH pH . PAA . PAA , , 12 18 3 . 24 7 . pH, , , ( ) . Perasafe , Perascope , Acecide , Scotelin . Perasafe . 35oC 1 L Perasafe g 15 . Perascope base 1 4,750 mL 2 250 mL.

6 Acecide 1 50 mL, 2 50 mL 900 mL . Scotelin 4 L 90 mL 4 , 80 . 2% Hydrogen peroxide Steris Corporation .4. Electrolyzed Acid WaterSuper-oxidized water (HClO) OH , . , , , . 5 24 .. Hicro-S Medilox Cleantop Sterilox.

7 5. 1) Chlorine dioxide: Vol. 43 (Suppl 2), 2011 (167-169)169 2 . , .. Tristel , Dexit , Medicide .2) : ..3) : Ethyl isopropyl alcohol 50% . flushing .4) Peroxygen compounds (Virkon ): GA , , enterovirus . 5) Quarternary Ammonium.

8 (minimum effective con-centration) , . (standard precaution) 1 1 , , , , . 1.. 2011; 41 .. 2010; 40 , .. , .. 2007; 34 Beilenhoff U, Neumann CS, Rey JF, et al. ESGE-ESGENA guideline: cleaning and disinfection in gastrointestinal endos-copy Update 2008. Endoscopy 2008;40 .. 2009;39 .. - 2011;6 Rutala WA, Weber DJ. CDC Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008 BSG guidelines for decontamination of equipment for gastro-intestinal endoscopy.

9 Report of a Working Party of the British Society of Gastroenterology Endoscopy Committee. February 2008. Rideout K, Teschke K, Dimich-Ward H, et al. Considering risks to healthcare workers from glutaraldehyde alternatives in high?level disinfection. J Hospital Infect 2005;59 Axon ATR, Banks J, Cockel R, et al. Disinfection in upper di-gestive tract endoscopy in Britain. Lancet 1981; Cowan RE, Manning AP, Ayliffe GAJ, et al. Aldehyde dis-infectants and health in endoscopy units. Report of a British Society of Gastroenterology Working Party. Gut 1993;34:1641- Hanson JM, Plusa SM, Bennett MK. Glutaraldehyde as a pos-sible cause of diarrhoea after sigmoidoscopy. Br J Surg 1998; 85 Janos G, Mahoney A, Murray J, et al. Chemical Colitis due to endoscope cleaning solutions: a minic of pseudomembranous colitis.

10 Gastroenterology 1995;(1988) West AB, Kuan SF, Bennick M, et al. Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak. Gastroenterology 1995;108:1250- Durante L, Zulty J, Israel E, et al. Investigation of an outbreak of bloody diarrhea: association with endoscopic cleaning sol-ution and demonstration of lesions in an animal model. Am J Med 1992;92 Griffiths PA, Babb JR, Bradley CR. Glutaraldehyde resistant Mycobacterium chelonae from endoscope washer disinfectors. J Appl Microbiol 1997;82 Medical Devices Agency-MDA/2004/022.