Haemostasis - Tcoag

1 AHaemostasisCatalogue1 ReagentsTriniCLOT Routine ReagentsPT 2aPTT 2 Fibrinogen 3 Thrombin Time 3 Factor Deficient Plasmas 3 Solutions 3 TriniLIA D-DimerTriniLIA D-Dimer 4 TriniCLOT Speciality ReagentsTriniCLOT Protein C 5 TriniCLOT Protein S 5 TriniCLOT Lupus Screen and Confirm 5 TriniCHROM Speciality ReagentsTriniCHROM Antithrombin IIa and TriniCHROM Antithrombin Xa 6 TriniCHECK ControlsTriniCHECK Controls 7 TriniCAL Reference PlasmasTriniCAL INR & Quick 8 TriniCAL Reference Plasma 8 TriniCAL Fibrinogen 8 TriniLIZE ELISA based AssaysTriniLIZE tPA Activity 9 TriniLIZE PAI-1 Antigen 9 TriniLIZE PAI-1 Activity 9 TriniLIZE Stabilyte tubes 10 TriniLIZE tPA/PAI Depleted Plasma RUO 10 TriniLIZE PAI Activity Control RUO 10 Fibrinolysis Reference Plasma RUO 10 Platelet Aggregation ReagentsRistocetin Cofactor Assay 11 Platelet Agonists 11 Instruments and ConsumablesDestiny Max 14 Destiny Plus 16KC4 Delta and KC1 Delta 18 Other ConsumablesThrombolyzer and MTX 20 COnTEnTSNote: availability depending upon the country2 TriniCLOT Routine ReagentsPTTriniCLOT PT Reagents are lyophilised thromboplastins from either rabbit or human sources which guarantee consistently accurate results.

2 Convenient and reliable, TriniCLOT PT Reagents are the quality PT reagents of choice for your Haemostasis PT HTF (HTF = Human Tissue Factor) From cultured human cells; Only true human thromboplastin in the market. ISI International Sensitivity Index (ISI) value (optical and mechanical) provided with each batch. Calibrated against WHO international reference thromboplastin preparation. Used with TriniCHECK PT Excel S and TriniCLOT PT Excel TriniCLOT PT Excel S (ISI = ): higher sensitivity to Factors II, VII and X. TriniCLOT PT Excel (ISI = ): moderate sensitivity to the extrinsic factors. International Sensitivity Index (ISI) value (optical and mechanical) provided with each batch. Buffer for reconstitution included in each package. Calibrated against WHO international rabbit reference thromboplastin preparation.

3 Used with TriniCHECK numberproduct namepackagingisiblue dyesourcestabilityT1101 TriniCLOT PT HTF 20 mL10 x 20 sHuman10 days at 2-8 CT1102 TriniCLOT PT HTF 6 mL10 x 6 days at 2-8 CT1103 TriniCLOT PT Excel S 20 mL5 x 20 days at 2-8 CT1104 TriniCLOT PT Excel S 6 mL10 x 6 days at 2-8 CT1106 TriniCLOT PT Excel 6 mL10 x 6 days at 2-8 CaPTTT riniCLOT aPTT S and TriniCLOT aPTT HS are liquid, ready to use, aPTT reagents intended for screening for deficiencies of the intrinsic coagulation pathway. These reagents contain purified phospholipids and a particulate activator (micronized silica), which are stabilized in an appropriate Automated aPTT is a lyophilized aPTT reagent and is considered to be the reagent of choice in the market due to its moderate factor and heparin sensitivity. TriniCLOT aPTT S: moderate sensitivity to the intrinsic factors, lupus and heparin.

4 TriniCLOT aPTT HS: high sensitivity to the intrinsic factors, lupus and heparin. No reconstitution required with TriniCLOT aPTT S and TriniCLOT aPTT HS. Used with TriniCHECK plasmas. TriniCLOT Automated aPTT contains a Platelet Factor 3 reagent (rabbit brain phospholipids) plus a particulate activator (micronized silica) in a suitable numberproduct namepackagingformatcacl2 in kitactivatorstabilityT1201 TriniCLOT aPTT S 10 mL5 x 10 mLLiquidYe sSilica30 days at 2-8 CT1202 TriniCLOT aPTT S 3 mL5 x 3 mLLiquidYe sSilica30 days at 2-8 CT1203 TriniCLOT aPTT HS 10 mL10 x 10 mLLiquidNoSilica30 days at 2-8 CT1204 TriniCLOT aPTT HS 3 mL10 x 3 mLLiquidNoSilica30 days at 2-8 CT1205 TriniCLOT Automated aPTT 6 mL10 x 6 mLLyophilisedNoSilica7 days at 2-8 CT1206 TriniCLOT Automated aPTT 3 mL10 x 3 mLLyophilisedNoSilica7 days at 2-8 CT1902 TriniCLOT Calcium Chloride M10 x 10 mLLiquidUntil expiry date3 FibrinogenTriniCLOT Fibrinogen is intended for quantitative determination of fibrinogen in plasma.

5 TriniCLOT Fibrinogen utilizes the Clauss method for fibrinogen determination. An excess of thrombin is used to convert fibrinogen to fibrin in diluted plasma such that the rate of reaction is a function of fibrinogen concentration. TriniCLOT Fibrinogen provided in kit format and as individual components. Used with separate TriniCHECK Control 1 (T4101) and TriniCHECK Abnormal Control (T4104).part numberproduct namepackagingT1301 TriniCLOT Fibrinogen KitTriniCAL Fibrinogen: 2 x 1 mL TriniCLOT Fibrinogen reagent (75 NIH): 3 x 6 mL TriniCLOT Imidazole Buffer: 2 x 20 mLpart numberproduct namepackagingstabilityT1302 TriniCLOT Fibrinogen 6 mL (75 NIH)10 x 6 mL12 days at 2-8 CT1901 TriniCLOT Imidazole Buffer6 x 20 mLUntil expiry dateT5104 TriniCAL Fibrinogen10 x 1 mL1 day at 2-8 CThrombin TimeTriniCLOT Thrombin Time is intended for the determination of functional fibrinogen in human plasma.

6 The enzyme, thrombin, is the penultimate protein in the clotting sequence, acting upon soluble fibrinogen and converting it to insoluble fibrin. A prolonged thrombin clotting time will result at fibrinogen levels of approximately 200 mg/dL and below. Nonfunctional fibrinogen molecules will also result in a prolonged thrombin time. TriniCLOT Thrombin Time is sensitive to the presence of heparin. Used with TriniCHECK Control 1 (T4101) and TriniCHECK Abnormal Control (T4104). part numberproduct namepackagingstabilityT1411 TriniCLOT Thrombin Time 1 mL (10 NIH)10 x 1 mL30 days at -20 CT1414 TriniCLOT Thrombin Time 4 mL (10 NIH)10 x 4 mL30 days at -20 CFactor Deficient plasmasA full suite of immuno-depleted TriniCLOT Factor Deficient Plasmas for all the extrinsic and intrinsic factors is Factor II, V, VII or X Deficient Human Plasma are intended for the quantitative determination of extrinsic factors in human plasma by clotting assay.

7 TriniCLOT Factor VIII, IX, XI or XII Deficient Human Plasma are intended for the quantitative determination of intrinsic factors in human plasma by clotting assay. TriniCLOT Factor VIII may also be used as a negative control in von Willebrand Factor assays. Used with TriniCHECK Control 1 (T4101), TriniCHECK Abnormal Control (T4104) and TriniCAL Reference Plasma (T5102).part numberproduct namepackagingstabilityT1502 TriniCLOT Factor II10 x 1 mL8 hours at 2-8 CT1505 TriniCLOT Factor V10 x 1 mL8 hours at 2-8 CT1507 TriniCLOT Factor VII10 x 1 mL8 hours at 2-8 CT1508 TriniCLOT Factor VIII10 x 1 mL8 hours at 2-8 CT1509 TriniCLOT Factor IX10 x 1 mL8 hours at 2-8 CT1510 TriniCLOT Factor X10 x 1 mL8 hours at 2-8 CT1511 TriniCLOT Factor XI10 x 1 mL8 hours at 2-8 CT1512 TriniCLOT Factor XII10 x 1 mL8 hours at 2-8 CSolutionspart numberproduct namepackagingstabilityT1901 TriniCLOT Imidazole Buffer6 x 20 mLUntil expiration dateT1902 TriniCLOT Calcium Chloride M10 x 10 mLUntil expiration date4 TriniLIA D-DimerElevated levels of D-Dimer are associated with thrombotic disorders, such as Deep Venous Thrombosis (DVT), Pulmonary Embolism (PE) and Disseminated Intravascular Coagulation (DIC)

8 As well as other conditions, such as cancer. The presence of elevated D-Dimer levels is not sufficient for the diagnosis of a thrombotic disorder, but the absence of elevated D-Dimer levels when used with the appropriate algorithm may be used to rule out the presence of DVT and D-DimerTriniLIA D-Dimer is a polystyrene micro-particle agglutination assay for the quantitative determination of fibrin degradation products containing D-Dimer in citrated human plasma on the Destiny Max and Destiny Plus analysers at 405nm. Controls sold numberproduct namemodepackagingstabilityT3101 TriniLIA D-DimerAutomatedD-Dimer Reagent: 4 x 2 mL D-Dimer Reaction Buffer: 4 x 4 mL D-Dimer Diluent: 1 x 4 mL TriniCAL D-Dimer: 1 x 1 mLReagent: 14 days at 2-8 C Reaction Buffer: 14 days at 2-8 C Diluent: 14 days at 2-8 C TriniCAL D-Dimer: 3 days at 2-8 C T4303 TriniCHECK D-Dimer 1 Control plasma4 x 1 mL2 days at 2-8 C T4304 TriniCHECK D-Dimer 2 Control plasma4 x 1 mL3 days at 2-8 C T4305 TriniCHECK D-Dimer 3 Control plasma4 x 1 mL3 days at 2-8 C 5 TriniCLOT Speciality ReagentsTriniCLOT Protein C TriniCLOT Protein C kit is intended for the quantitative determination of plasma Protein C activity by clotting assay.

9 In this assay, Protac is co-lyophilized with aPTT reagent to form a reagent which activates both Protein C and the contact factors of the intrinsic pathway. With this reagent the clotting time of normal plasma is very long (>100 seconds) while that of Protein C deficient plasma is essentially the same as the aPTT (about 30 40 seconds). When patient plasma is mixed with Protein C deficient plasma the prolongation of the clotting time is proportional to the amount of Protein C in the patient plasma. Used with TriniCHECK Control plasmas, TriniCAL Reference plasma (T5102) and TriniCHECK Abnormal Control (T4104)PART NUmBERPRODUCT NAMEPACKAgINgSTABILITyT1601 TriniCLOT Protein CPC Activator: 3 x mL PC Deficient Plasma: 3 x mL PC Control Plasma: 3 x mL PC Dilution Buffer (10X): 3 x 5 mLProtein C Activator: 48 hours at 2-8 C Working Dilution Buffer: 1 month at 2-8 C TriniCLOT Protein STriniCLOT Protein S is intended for the quantitative determination of Protein S activity in human plasma.

10 The TriniCLOT Protein S assay is a clotting-based plasma assay. In the assay, dilutions of patient plasma are mixed with Protein S depleted plasma. A reagent that contains Factor Xa, activated Protein C and phospholipids is added to the mixture. Following a 5 minute incubation period, calcium chloride is added to initiate clot formation. Under these conditions, the prolongation of the clotting time is directly proportional to the concentration of the Protein S in the patient plasma. Used with TriniCHECK Control 1 (T4101), TriniCAL Reference Plasma (T5102) and TriniCHECK Abnormal Control (T4104).part numberproduct namepackagingstabilityT1602 TriniCLOT Protein SPS Activator Reagent: 4 x 1 mL PS Dilution Buffer (10X): 2 x mL PS Control Plasma: 2 x mL PS Depleted Plasma: 4 x 1 mLPS Activator Reagent: 4 hours at 2-8 C PS Dilution Buffer: 30 days at 2-8 C PS Control Plasma: one hour at 2-8 CPS Depleted Plasma: 4 hours at 2-8 C TriniCLOT Lupus Screen and ConfirmTriniCLOT Lupus Screen and TriniCLOT Lupus Confirm are simplified dilute Russell s Viper Venom Time (dRVVT) reagents, intended to specifically detect Lupus Anticoagulants (LAs), a type of anti-phospholipid antibody.