HbA1c 値の評価が困難であったことから異常ヘモグロビ

1 HbA1cHbA1cHbA1cHbA1c HbA1c 1 72 2011 7 19 (122mg/dl) JDS HPLC 10 9 75g (OGTT) 82mg/dl, 30 161mg/dl, 120 142mg/dl HbA1c (JDS) HPLC (GA) ( ) HbA1c (GA/4+ ) OGTT 2 64 2012 7 30 113mg/dl JDS, HPLC HbA1c (JDS) , 96mg/dl GA ( ) HbA1c HbA1c A1c HPLC 2 HPLC HbA1c HbA1c HbA1c GA HbA1c Val-1 60 Val-1 6 Lys-17,20,66 18 Lys-7,16 18 N -N-(1-deoxyfructosyl)-Hb HbA1c (HPLC ) (HPLC)

2 A b Labile c c Stable c c HbA0(90%) hba1 (7%) 4%4%4%4%HbA2(2%)HbFHbFHbFHbF(((( ) ) ) )DIABETES UPDATE P25, 1111 1 72 2011 7 19 (BMI ) 150/78 mmHg CR(40) 1 (40) 1 (5) 1 (100) 1 (75) 1 D (10) 1 WBC 5800/ l, RBC 512 / l, MCV fl, MCH pg, MCHC g/dl, Hb g/dl, Hct %, Plt / l BUN , Cre mg/dl, GOT 15 U/ml, GPT 6 U/ml, -GTP 21 U/ml T-Cho 206 mg/dl, TG 72 mg/dl Na 139 mEq/l, K mEq/l, Cl 98 mEq/l PPG 122 mg/dl, HbA1c % JDS , HPLC < 75g.

3 10 9 > (GA) HbA1c (GA / 4+ ) HbA1c (JDS) HPLC 2222 2 64 2011 8 4 105 mg/dl, HbA1c (JDS HPLC 2012 7 30 cm 71 kg (BMI kg/m2) 126/80 mmHg 92cm RBC 522 / l, Hb g/dl, Hct %, Plt / l FPG 104 mg/dl, TG 72 mg/dl, HDL 46 mg/dl HbA1c % JDS , HPLC % 2011201120112011 8888 4444 2012201220122012 7777 30303030 GA HbA1c HPLC B HPCLHPCLHPCLHPCL 24242424 110 HPLCHPLCHPLCHPLC (((( GAGAGAGA 10 11 HbF 2008 2 2)))))

4 HbA1c DIABETES JOURNAL, Vol .40 2012, P42 Diabetol Int (2011) 2:202-207 Cases with with Hb Toranomon show abnormal HbA1c levels measured by upgraded high-performance liquid chromatography models. H Ijima, et al. (Hb J-Lome) , , 2012 1 HbA1c (Hb J-Lome) 1 P627~631 47 288mg/dl HbA1c (JDS) GA , GAD codon59 AAG(Lys) AAC (Asn) Hb J-Lome)

5 HbA1c GA HbA1c HbA1c 1962 37 Hb Diabetes 25 579,1962 1967 100 100 ( 91:1195, 2002) ()