Highlights Of Clinical Studies Using Proteolytic …

1 Proteolytic enzymes are substances produced inanimals and plants that are used to break downproteins. They are involved in digestion, cell turnover,blood clotting, cell division, immune functions, andinflammation , if inflammation is severe enough,these naturally occurring enzymes are eitherinactivated or cannot get to their sites of can be supplied as nutritional supplementsto correct local enzymes have been documented inhundreds of medical literature reports to haveeffectiveness for the following conditions: bruising,sprains, strains, fractures, low back pain, dentalsurgery, digestive difficulties, arthritis, ..L. Bucci, Proteolytic enzymes and Acute Injuries, The NutritionalSupplement Advisor; Chiropractic Products; June 1988In the article Sports Injuries and ProteolyticEnzymes , the authors summarized 14 Studies onproteolytic enzymes .

2 Over 1500 subjects werestudied. The type of Proteolytic enzymes used in thestudies varied. Trypsin/ chymotrypsin tablets wereused in six Studies , bromelain in four, papain in two,streptokinase/streptodornase in one, and an unspecifiedmix of Proteolytic enzymes in another. Favorable results were obtained in every study, with allreporting significant improvements in reduction of pain,swelling, edema, recovery time, period of disability, timeof return to normal activities and leg-raise stiffness (forlow back pain).The amount of time needed to resolveinjuries was halved in most subjects with supplements. L Bucci, J Stiles, Sports Injuries and Proteolytic enzymes , Today s Chiropractic,Mar/Apr 1987, 31-34 Further research has shown thatproteolytic enzymeuse will: 1) speed up the inflammatory process andbring it to a conclusion; 2) help clean up the wasteproducts in the area; 3) decrease pain and swelling; 4)dissolve any small blood clots floating nearby; 5)improve the supply of nutrients to the tissue,improving circulation; and 6) aid in easing bloodflow.

3 A Cichoke, enzymes and Enzyme Therapy, Keats Publishing, p. 182 Highlights Of Clinical StudiesUsing Proteolytic EnzymesThe following are Highlights from just a few of thehundreds of Studies and articles available onproteolytic study involved 59 patients with blunt injuries to themusculoskeletal with bromelain resulted ina clear reduction in all four parameters tested; swelling,pain at rest and during movement, and M. Bromelain in blunt injuries of the locomotor system. A study of observedapplications in general practice. Fortschr Med 1995; 1 13:303- 306A double-blind placebo-controlled studyof 44individuals with sports-relatedankle injuries found thattreatmentwith Proteolytic enzymes resulted infaster healing and reduced the timeawayfrom training by about 50%.

4 Baumuller M. The application of hydrolytic enzymes inblunt wounds to the soft tissue and distortion of theankle joint: a double blind clinic al trial (Translatedfrom German). Allgemeinmedizin. 1990;19:178-The statements herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any of trypsin (a Proteolytic enzyme)in the buttocks immediately after injuryallowedblack eyes and bruises in boxersto subside in one to three days, ratherthan the usual 10 to 14 L. Lichtman, Traumatic Injury in Athletes, International e 170:322-325 (1957).After oral application of bromelain asignificant reduction of swelling wasobserved in traumatically induced hind-legedema in G, Seifert J.

5 The effect of Proteolytic enzymes (traumanase) on posttraumatic edema. Fortschr Med 1981;99 double-blind placebo-controlled study of44individuals with sports-related ankleinjuries found thattreatment withproteolytic enzymes resulted in fasterhealing and reduced the time awayfromtraining by about 50%.Baumuller M., The application of hydrolytic enzymes in bluntwounds to the soft tissue and distortion of the ankle joint: adouble blind clinic al trial (Translated from German).Allgemeinmedizin. 1990;19 double-blind placebo-controlled trial of71 individuals with finger fractures foundthattreatment with Proteolytic enzymessignificantly improved PC. The use of a trypsin-chymotrypsin formulation infractures of the hand.

6 Br J Clin Pract. 1969;23 orally administered enzymes havevery fewundesirable side effects, thistreatment is suitable for all patients withsciatica due to intervertebral disc Clinical benefit is presumably due todecrease of inflammatory edema in the nerveroot and, in suitable cases, Clinical resultshave been spectacularly good. Treatment of Sciatica Due to lntervertebral Disc Herniation,Rheuma- tology and Physical Medicine, Vol. Xi, No. 1, 1971 The results indicate that enzyme therapyminimizes the edema so frequently seenfollowing hand surgery. In the group treatedwith enzymes , 21 of 25(84%) patients wereconsidered symptom free on the 7thpostoperative day. In the placebo treated grouponly 4 of 29 (14%) were symptom free.

7 Thiswas a randomized, double blind Value of Oral Proteolytic enzymes FollowingHand Surgery, Archives of Surgery, January, of bromelain prior tosurgeryreduced the average number ofdays for complete reduction of pain to , and disappearance ofinflammation from to days, ascompared with GC, Zafi-an JN, Zayon GM. Evaluation of a plant proteolyticenzyme for the control of inflammation and pain. J Dent Med 1964;19 significant reduction of pain and swellingwas observed in 81% of oral surgerypatients after bromelain Double Blind Crossover Study of a Plant ProteolyticEnzyme in Oral Surgery, Journal of Dental Medicine, 1965 This double-blind study investigated the use ofenzymes in ankle joint injuries. The enzymegroup experienced faster reduction of swelling,faster return to joint mobility, and decreasedpain during resting or movement as comparedto the placebo time during whichpatients were unable to work or train wassignificantly shorter (reduced by some 50 %)with enzyme Baumuller, Therapy of Ankle joint Distortions withHydrolytic enzymes ; Results of Double-Blind Clinical Trials, Allgem-einmedizin 19:178-182 (1990).

8 An eight-week, double-blind study of enzymes provedparticularly effective in alleviating pain,improving mobility, and reducing softtissue swelling and muscle Uffelmann, Enzyme treatment of soft tissue rheumatism, from lecture, First International Conference on Systemic EnzymeTherapy. Univ. of Klagenfurt, Klagenfurt, Austria. September 12, study found thatbromelain has beenfound to dramatically reducepostoperative swelling in controlledhuman AP. Minimizing post-operative edema and ecchymoses by theuse of oral enzyme preparation (bromelain) EENT Monthly1962;41 wasthe most potent of nine anti-inflammatory substances tested onexperimentally-induced edemas in G, Seifert J. The effect of Proteolytic enzymes (traumanase) on posttraumatic edema.

9 Fortschr Med 1981;99 sixteen patient double-blind, placebo-controlled study of oral surgery patients showedbromelain concentrate significantly reduced thedegree and duration of both swelling and pain. A Double-Blind Crossover Study of a Plant ProteolyticEnzyme in Oral Surgery , Tassman, Gustav C., , et al,Journal of Dental Medicine, April, 1956;20(2):51-53.(Address: Gustav C. Tassman, , 715 Medical ArtsBuilding, 15th and Walnut Streets, Philadelphia, PA )This double blind study of patientssustaining sports injuries foundconsiderably less bruising, reducedswelling, a quicker return to function andfitness to resume play in the proteolyticenzyme treated Use of Proteolytic enzymes in Sporting Injuries, Journa l, Feb.

10 , 1971A preparation containingtrypsin andchymotrypsinwas tested on professionalfootball players. Two separatelyconducted double blind trials haveconfirmed the value of Proteolytic enzymetherapy in resolving inflammation andassociated edema and increasing recoveryrates. The overall reduction in recoverytime is 1. 3 days for hematoma and for sprains -an approximate 27%decrease in recovery time. The British Journal of Clinical Practice, September, 19703 Keys To Effective Supplementation1. Start supplementation as soon as possibleafter trauma2. Enteric coated tablets taken on emptystomach 3-4 times daily3. Multiple proteases in purest forms preferredL. Bucci, Proteolytic enzymes and Acute Injuries, TheNutritional Supple ment Advisor; Chiropractic Products;June 1988