Transcription of 溶連菌性咽頭炎での 抗菌薬使用 - Hospitalist
1 Clinical Question 2018 11 12 .. 22 .. Sick contact .. E4V5M6. General appearance: patient is in mild distress : : 90 / : 113/72mmHg : 18 / SpO2: 99%( ).. ( ).. : . : .. Centor criteria 4 , FeverPAIN 4 .. Clinical Question 1.. 2.. 2012 .. 3 .. Clin Infect Dis. 2012 Nov 15;55(10):1279-82.. 2001 Centor score .. 0-1 . 2-3 . 4 . Ann Intern Med. 2001 Mar 20;134(6):506-8. Ann Intern Med. 2001 Mar 20;134(6):509-17.. 2012 Centor score .. 0-2 . 3-4 . Clin Microbiol Infect. 2012 Apr;18 Suppl 1:1-28.. :130 . :144 . 2740 . 30 .. 1.. 2.. 1.. 1. (quinsy) . NNT=4300. BMJ. 2007 Nov 10;335(7627):982. 2.. NNT=60(1950 ). BMC Cardiovasc Disord. 2005 May 31;5(1):11. (1980 ). Cochrane Database Syst Rev.
2 2013 Nov 5;(11):CD000023. 2.. 3 5 .. 2 .. V . V .. Clin Infect Dis. 2012 Nov 15;55(10):1279-82. V .. G. 2018 . G . ( ).. 50mg/kg( 1000mg)1 1 10 .. palatable . Clin Infect Dis. 2012 Nov 15;55(10):1279-82. 3 . FDA . GAS .. IDSA .. Clin Infect Dis. 2012 Nov 15;55(10):1279-82. 3 -1.. \ \ \67/100mg . (GE:\ ) (GE:\ ) (GE:\ ). 8C/day 3C/day 2T/day 10 5 5 . \920(GE:\760) \879(GE:\ ) \670(GE:\351). 3 -2.. 1 2000mg IDSA 2 .. vs.. 10mg/kg 4 10 . 7mg/kg 2 5 .. 72% 90%(95% . ) . Arch Pediatr Adolesc Med. 1997;151(1):45-49. V 250mg 4 10 . 150mg 2 5 . GAS . Antimicrob Agents Chemother. 1998 May;42(5):1073-5. vs.. 10mg/kg 4 . 60 90mg/kg/day .. GAS . vs.. V 600mg 4 10 . 100mg 2 5.
3 GAS . Scand J Infect Dis. 1994;26(1):59-66. vs.. V 10mg/kg(max:250mg) 4 10 . 5mg/kg(max:100mg) 2 5 . 10mg/kg(max:100mg) 1 10 . 76%,75%,89% . 10 . Arch Pediatr Adolesc Med. 1994 Oct;148(10):1053-60. vs.. V 10mg/kg(max:250mg) 4 .. Clin Infect Dis. 2012 Nov 15;55(10):1279-82.. 1% . Clin Infect Dis. 2012 Nov 15;55(10):1279-82. 10%. JANIS 2017 .. 10 V(15mg/kg 3) 6 . (25mg/kg 2) GAS .. Pediatr Infect Dis J. 1996 Aug;15(8):678-82. 10 V(25 4) 6 . (500mg 2) GAS . Scand J Infect Dis. 1996;28(5):497-501.. 1.. 2.. 3.. 4.. 5. Bioavailability .. 10 .. Clin Infect Dis. 2012 Nov 15;55(10):1279-82. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD004872. 10 .. Take Home Message.
4 NNT.
