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最終-薬剤部HP-2012年 - コピー

AMP AMP GLUT4 1 1-31 101 1 500mg 750mg 27 27 1 78% 6 22 750mg 65 BMI 25 ALT 30 IU/L 270 IU/L 6 1-32

(A) リスク因⼦ (B)リスク因⼦数と下痢発現率の関係 0.01 0.1 1 10 100 1000 ALP>270IU/L ALT>30IU/L BMI>25kg/m2 Age<65 Female Initial Dose 750mg 2.774 (1.101-6.988) 0.030

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Transcription of 最終-薬剤部HP-2012年 - コピー

1 AMP AMP GLUT4 1 1-31 101 1 500mg 750mg 27 27 1 78% 6 22 750mg 65 BMI 25 ALT 30 IU/L 270 IU/L 6 1-32 3 750mg AMP AMP ATP + 1-31 AMP (A) (B)

2 >270IU/LALT>30IU/LBMI>25kg/m2 Age<65 FemaleI n it ia l D o se 7 5 0 ( ) ( ) ( ) 38 0 (1 .1 26 71 ) 16 Odds ratio (95% CI)P ( ) ( ) ( ) 90 0 (1 .1 33 20 ) 26=====Odds ratio0123456020406080100(2/2)(6/8)(5/9)( 7/22)(4/32)(2/21)(1/7) Number of risksIncidence of diarrhea (%) [ ] 1) Okayasu S, Kitaichi K, Hori A, Matsuura K, Suwa T, Horikawa Y, Yamamoto M, Takeda J, Itoh Y. A study on the risk and prevention of diarrhea associated with metformin treatment. J Clin Pharm Ther (submitted).

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