Hydrazine 和訳＋Table＋Appendix E - nihs.go.jp

1 1 (AEGL) Hydrazine (302-01-2) Table AEGL Hydrazine 302-01-2 (Final) ppm 10 min 30 min 60 min 4 hr 8 hr AEGL 1 AEGL 2 23 16 13 AEGL 3 64 45 35 25 C mm Hg H2 NNH2 2,000 8,000 ppm 2- 2 AEGL AEGL - - Cn t = k n ten Berge et al.

2 1986 n Cn t = k n 3 1 AEGL-1 House 1964 ppm 24 89 24 AEGL-1 24 n 3 House 1964 24 ppm AEGL-1 k = ppm3 24 h = ppm3 h 3 3 AEGL-1 ppm 30 1 4 8 ppm level of distinct odor awareness LOA 63 ppm Appendix E LOA 10 % LOA AEGL-2 Latendresse 1995 750 ppm 1 1 750 ppm 1 n = 3 1 n = 1 AEGL 3 3 10 3 AEGL-2 2 Latendresse 1995 Huntingdon Research Centre HRC 1993 3 60 AEGL-2

3 AEGL-2 AEGL-3 HRC 1993 1 LC50 3,192 ppm 3 1 1,064 ppm 750 ppm 1 Latendresse et al. 1995 Cn t = k n 3 1 AEGL-2 AEGL-3 10 HRC 1993 3 30 AEGL-3 10-4 10-5 10-6 AEGL AEGL-2 10-4 AEGL AEGL 4 Table AEGL APPENDIX E Level of Distinct Odor Awareness (LOA) for Hydrazine DERIVATION OF THE LOA.

4 Hydrazine The level of distinct odor awareness (LOA) represents the concentration above which it is predicted that more than half of the exposed population will experience at least a distinct odor intensity, about 10 % of the population will experience a strong odor intensity. The LOA should help chemical emergency planners and responders in assess-ing the public awareness of the exposure due to odor perception. The LOA derivation follows the guidance given by van Doorn et al. (2002). The odor detection threshold (OT50) for Hydrazine was calculated to be 4 ppm (van Doorn et al. 2002). The concentration (C) leading to an odor intensity (I) of distinct odor detection (I = 3) is derived using the Fechner function: I = kw log (C/OT50) + For the Fechner coefficient, the default of kw = will be used due to the lack of chemical-specific data: 3 = log (C/4) + which can be rearranged to log (C/4) = ( ) = and results in C = ( ) 4 = 47 ppm The resulting concentration is multiplied by an empirical field correction factor.

5 It takes into account that in every day life factors, such as sex, age, sleep, smoking, upper airway infections and allergy as well as distraction, increase the odor detection threshold by a factor of 4. In addition, it takes into account that odor perception is very fast (about 5 seconds) which leads to the perception of concentration peaks. Based on the current knowledge, a factor of 1/3 is applied to adjust for peak exposure. Adjustment for distrac-tion and peak exposure lead to a correction factor of 4 / 3 = The LOA for Hydrazine is 63 ppm. LOA = C = 47 ppm = 63 ppm ----------------------- ICSC ICSC :0281 Hydrazine Diamide Diamine Nitrogen hydride (anhydrous) N2H4 / H2N-NH2 CAS :302-01-2 RTECS :MU7175000 ICSC :0281 :2029 EC :007-008-00-3 / 40 C / 40 C ( ) / !

6 ! ( ) EU : T, N R : 45-10-23/24/25-34-43-50/53 S : 53-45-60-61 Note : E (UN Hazard Class) 8 (UN Subsidiary Risks) 3 and (UN Packing Group) I GHS - - - - ICSC :0281 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities IPCS CEC 1993 ICSC :0281 ; : : : : TLV ppm (TWA); ( ).

7 A3( ) (ACGIH 2009) MAK (H) (Sh) 2 (DFG 2009) : : 20 C : : 114 C 2 C ( = ) kPa(20 C) ( ) 20 C / ( ) mm2/s (20 C) 40 C( ) 270 C 100 vol ( ) log Pow ( / ) 24 C 270 C 2 3 ( ) UN2030 ( 37% 60 C ) 8 3 I ( 37% ) 8 II-III UN3293 (37% ) III CAS 7803-57-8(64% ) 10217-52-4(55% ) NFPA( ) H( )

8 4 F( )4 R( )3 ICSC :0281 IPCS, CEC, 1993