Transcription of HYPERCOAGULABILITY PANEL - AC Forum
1 HYPERCOAGULABILITY PANEL . COMMON DRUG. LAB TEST WHAT IT MEASURES MEANING OF ABNORMAL DISEASE STATE INFLUENCES. INFLUENCES. Elevated Factor VIII, trauma, (+) may indicate presence LUPUS-LIKE. INHIBITOR. LA-sensitive aPTT Time-to-clot test acute tissue inflammation, Heparin, heparin-like drugs ANTIPHOSPHOLIPID SYNDROME. of LA. TESTS. infection, cancer, HIV/AIDS. DIAGNOSTIC TESTS FOR. Time-to-clot test; Increased risk of dRVVT Unknown Vitamin K antagonists confirmation test for LA thrombosis Presence of antibodies 2-GP1 PANEL Detection of antibodies associated with increased SLE, rheumatic disease Unknown risk of thrombosis SLE, thrombosis, HIV/AIDS, Presence of antibodies CL-Antibody syphilis, fetal loss, infection, DM, Detection of antibodies associated with increased Penicillin, phenytoin PANEL cancer, severe bleeds; decreased risk of thrombosis in non-alcoholic fatty liver, CHF.
2 Low levels result in Thrombosis, liver disease, DIC, decreased degradation of elevated Factor VIII, presence of Vitamin K antagonists, Protein C Activity Function of Protein C. Factors V/VIII increased LA, severe infections, HIV, cancer, heparin risk of thrombosis pregnancy, Vitamin K deficiency ANTICOAGULANTS. ENDOGENOUS. Low levels result in Pregnancy, liver disease, decreased activation of nephrotic syndrome, infection, Vitamin K antagonists, Protein S Activity Function of Protein S. Protein C increased risk thrombosis, elevated Factor VIII, estrogen of thrombosis presence of LA, Vit.
3 K deficiency Active clot, DIC, hepatic disease, Heparin therapy, Vitamin K. A low level can result in nephrotic syndrome, protein- Antithrombin III Activity level of antithrombin antagonists, direct thrombin thrombophilia wasting conditions, sepsis, inhibitors, estrogen surgery Presence of mutation Factor V Leiden results in Factor V's PCR to detect mutation None None MUTATIONS. Mutation resistance to degradation by Protein C. Factor II/ Mutation results in Prothrombin PCR to detect mutation increased levels of None None 20210 Mutation thrombin in the bloo
