漫談白藜蘆醇 - info.fy.org.tw

1 Vol. 5911 4 (phytoalexin) 70 ( ) ( ) ( ) (Resveratrol) C14H12O3 ( - -) ( - -) 256-257 C 261 C ( D ) (piceid), 3,5,4'- -3- - -D 1989 (WHO) (LDL) ( 1)

2 Sinclair 2003 10 70% (Howitz 2003) 60% 30% 60% (Huntington's disease, HD) Sinclair Sir2 Sir2 / 12 Vol. 59 l mg/L mg/L 1000 mg/L 80 (Bertelli 1995) 1997 1 John Pezzuto (Jang 1997)

3 NF- B NF- B NF- B 72 - ( ) ( ) :1.

4 National Research Council Food and Nutrition Board Committee on Diet and Health: Diet and health: Implications for reducing chronic disease risk. National Academy Press. Washington, DC; Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954): Bertelli AA, Giovannini L, Giannessi D, Migliori M, Bernini W, Fregoni M, Bertelli A.

5 (1995) Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React. 17(1): Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275(5297): 218-220.