Innovations in Polymeric - HYDROMER

1 Innovations inPolymericCOSMETIC INGREDIENTSHYDROGELSA quatrix II hydrogel products developed and patented by HYDROMER , Inc., consist of two highlybiocompatible, water-soluble polymers supplied individually in an aqueous solution. The gel is formedwhen the two solutions are mixed together, no other process steps or additives are needed. This uniquecapability makes the Aquatrix II hydrogels extremely versatile for cosmetic formulations as compared toother commercially available hydrogels that often require irradiation, heat or chemical catalysts thatcan destroy many cosmetic actives. The Aquatrix II hydrogels are ideal for a wide range of cosmetictreatments including facial masks, moisturizers, lotions and therapeutic patches or wraps.

2 They havealso found extensive use in the medical field for wound care, burn dressings and drug has the capability to support your development from concept to finished product, includingprocess development of coated products in our pilot coating DermaSeal allergen-blocker polymer system is comprised of a patented synergistic combination ofbiocompatible naturally derived ingredients that provide a thin invisible film on the skin. DermaSealimproves the spreadability and consistency of foundations and makeup, while lubricating andmoisturizing the skin. DermaSeal provides skin protection against harmful environmental factors suchas allergens, pollutants, poisonous plants and chemicals.

3 DermaSeal allergen-blocker is ideal especiallyfor sensitive skin care products, sunscreens, lotions and is currently being sold to cosmetic companiesas a base for foundations and as a poison oak and ivy , Inc., has a class of hydrophobic polymer systems called AQUAMERE for cosmeticapplications. Aquamere polymer systems are formulated with biocompatible materials for forminginterpolymers with unique rheological and film forming properties . The polymer s film formationproperties help maintain active ingredients on the application site by imparting resistance to abrasionor rub-off. Aquamere technology is ideal for various cosmetic applications providing multifunctionalcapabilities that can satisfy unique cosmetic functional requirements such as water and rub-offresistance, adhesion to skin, moisture barrier, actives and pigment AQUATRIX IIRHEOLOGICALMODIFIERSThe BeAqua line consists of water-based viscosity modifiers with very effective rheological 200 exhibits a pronounced thixothropic behavior with fast 300 shows a strong rheopex fluid have strong water resistivity even after several minutes while still in a formative NAME.

4 Alcohol/Hydroxypropylcellulose/PEG-20 Methyl Glucose DistearateINCI NAME: PVP/Carboxymethyl ChitosanINCI NAME: H-Series - PVP/Polycarbamyl/Polyglycol EsterA-Series - PVP/Polycarbamyl/Polyglycol EsterC-Series - PVP/Dimethiconylmethacrylate/Polycarbamy l/Polyglycl EsterD-Series - PVP/Dimethiconylmethacrylate/Polycarbamy l/Polyglycl EsterHYDROGELCOSMETICINGREDIENTSALLERGEN -BLOCKERThe DermaSeal polymer system is a synergistic combination of biocompatible, naturally derived ingredients, which form a thin,continuous film on skin. DermaSeal allergen-blocker was developed for use in lotions, creams, sprays and ointments. DermaSealserves as a skin barrier to common irritants, detergents and plant derivatives.

5 This dermatologically compatible barrier,hydrophilic, nonionic, film former is commonly used in cosmetic applications for their moisturizing and allergen-blocker is a moisturizing polymer system which provides a thin invisible continuous film on the improves the spreadability and consistency of foundations and makeup, while lubricating and moisturizing the provides the value added property of skin protection against harmful environmental factors such as pollutants,poisonous plants and , allergen-blocker, was developed to serve as a skinbarrier to common irritants. Upon contact with the skin, allergenspromote an immune response resulting in visible skin irritation.

6 Inorder to examine its potential effectiveness as a barrier, DermaSeal,allergen-blocker, was tested using Attenuated Total ReflectanceInfrared Spectroscopy (ATR-IR). The technique (illustrated below)measures the rate of permeation of an allergen or other irritantthrough the barrier film. Upon passage through the film, irritantsare detected using infrared the ATR-IR technique, films of several currently marketedproducts, which claim skin protection, and several formulationsdeveloped in the laboratory including DermaSeal, were examinedfor permeability to the following known irritants: Disulfides (benzyl disulfide) Detergents (Sodium Lauryl Sulfate) Rubber Constituents (1,4- Phenylenediamine) Plant Derivatives (Catechol)Differences in breakthrough times (or protection) through films ofthe formulations were noted for each irritant.

7 For the plant irritant,protection times ranged from hr for commercial products Aand B formulations and 8 hrs for DermaSeal, allergen-blocker.(Note: maximum testing time was 8 hours). The results are shownon the Hypo-allergenic / sensitive skin products Skin and sun care products Color cosmetics Industrial hygiene and safety Topical active ingredient deliveryProduct Benefits Improves substantivity of actives in foundationmakeup, sunscreens and anti-bacterial products Provides unique after feel and sheencharacteristic in skin care products Reduces tackiness in formulations Improves the lubricity of formulations Film forming barrier to common irritants.

8 Greaseand oil Excellent affinity to skinSKINA llergenIrritationImmuneResponseZnSe CrystalBARRIER FILMA llergenInfrared BeamDetection of Allergen86420 PlantIrritantProtection Time (hours)RubberConstituentDetergentDisul!d e10 Dermaseal Product A Product B HYDROGELSA quatrix II cosmetic hydrogels are cold-formed gels requiring no additional curing energy. They arebased on a unique combination of PVP (polyvinylpyrrolidone) and Chitosan. PVP interacts withChitosan to form a hydrogel with three-dimensional structure that results in superior cohesive andelastic properties . Since Aquatrix II cosmetichydrogels require no irradiation or heat for gelformation, active ingredients and biomoleculescan be readily incorporated without impairingtheir biological II hydrogels are biocompatible andare non-irritating to the skin.

9 Both theviscoelastic and bioresorption profiles can bemodified to reveal unique rheologicalproperties for a broad range of II hydrogels possess the ability toabsorb a large amount of water, whilemaintaining their three dimensional II hydrogels can be used as filmformers to create flexible films, can be coatedor laminated onto a substrate or molded to accommodate product design. The Aquatrix II hydrogelsbecome lubricious with water or saline absorption. They can be used as a thickener and an loaded with vitamins, phospholipids, astringents, alpha hydroxy acids and other activeingredients, Aquatrix II Cosmetic Hydrogels readily deliver a variety of active ingredients to the skinprecisely where intended even close to eyes.

10 These products are available in several product forms,including hydrogel-containing patch systems which permit the application of active ingredients tothe skin, without messy fingers, and ease of removal without leaving hydrogel residue on the IIAQUATRIX IIPerformanceCharacteristicsThe physical properties of Aquatrix II hydrogels can betailored to meet a variety of performance requirementsby varying levels of tack and gel strength. Whenmixed, gel formation begins immediately anddepending on the formulation it reaches maximum gelstrength within seconds or minutes. Aquatrix IIhydrogels may be deposited on or between II hydrogels are film formers and moisturizersand provide a cooling and soothing sensation to theskin when applied as face masks and eye patches.