INTRODUCING XIENCE Sierra - xiencestent.com

1 INTRODUCINGXIENCE SierraWith the safety you ve always relied on and the deliverability you ve always wanted, choosing the right stent is now an easier contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 1 of 13 Information contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 2 of 13 XIENCE Sierra REQUIRES 73% LESS FORCE TO CROSS A LESION THAN SYNERGY AND 64% LESS FORCE THAN RESOLUTE ONYXBest-in-Class Deliverability11.

2 Bench test data shows that XIENCE Sierra performed better in crossability and was not statistically different in trackability and pushability compared to Resolute Onyx and SYNERGY stents. Bench test results may not necessarily be indicative of clinical performance. Test performed by and data on file at Abbott. Testing performed on XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n=5. Catheter performance crossability test measures average force to cross a challenging lesion Force (gm)051015202530 ResoluteOnyxXIENCES ierraSYNERGYup to 73% less forceLOWER IS BETTERI nformation contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force.

3 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 3 of 13 Best-in-Class Deliverability11. Bench test data shows that XIENCE Sierra performed better in crossability and was not statistically different in trackability and pushability compared to Resolute Onyx and SYNERGY stents. Bench test results may not necessarily be indicative of clinical performance. Test performed by and data on file at Abbott. Testing performed on XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n=5. Catheter performance crossability test measures average force to cross a challenging lesion Based on customer feedback on testing XIENCE Sierra in the Synthetic Anatomical Model developed by Test performed by and data on file at Abbott.

4 XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n= balloon provides maximum flexibility and further lowers crimped profileSYNERGY "Resolute Onyx " XIENCE Alpine " XIENCE Sierra "For Even the Most Challenging Lesions2 ULTRA LOW stent CROSSING PROFILE OF " FOR EASIER CROSSING ENABLED BY THE NEW stent DESIGN AND BALLOON TECHNOLOGY3 Information contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 4 of 13 Best-in-Class Deliverability1 Thinner balloon provides maximum flexibility and further lowers crimped profileSYNERGY "Resolute Onyx " XIENCE Alpine " XIENCE Sierra "For Even the Most Challenging Lesions21.

5 Bench test data shows that XIENCE Sierra performed better in crossability and was not statistically different in trackability and pushability compared to Resolute Onyx and SYNERGY stents. Bench test results may not necessarily be indicative of clinical performance. Test performed by and data on file at Abbott. Testing performed on XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n=5. Catheter performance crossability test measures average force to cross a challenging lesion Based on customer feedback on testing XIENCE Sierra in the Synthetic Anatomical Model developed by Test performed by and data on file at Abbott. XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n= LOW stent CROSSING PROFILE OF " FOR EASIER CROSSING ENABLED BY THE NEW stent DESIGN AND BALLOON TECHNOLOGY3 Information contained herein for distribution outside the only.

6 Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 5 of 13 OPTIMIZED MULTI-LINK stent DESIGN ALLOWS FORTIGHTER CRIMPING AND SMOOTHER CROSSINGBest-in-Class Deliverability1 SLIMMER, MORE FLEXIBLE LINKS NARROWER CREST1. Bench test data shows that XIENCE Sierra performed better in crossability and was not statistically different in trackability and pushability compared to Resolute Onyx and SYNERGY stents. Bench test results may not necessarily be indicative of clinical performance. Test performed by and data on file at Abbott. Testing performed on XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n=5.

7 Catheter performance crossability test measures average force to cross a challenging lesion contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 6 of 13Re-engineered delivery system ensures consistent force transmission for outstanding pushabilityDislodgement (lbf) IS BETTERBest-in-Class Deliverability1 Outstanding stent retention2 for confident crossing of challenging anatomy1. Bench test data shows that XIENCE Sierra performed better in crossability and was not statistically different in trackability and pushability compared to Resolute Onyx and SYNERGY stents. Bench test results may not necessarily be indicative of clinical performance.

8 Test performed by and data on file at Abbott. Testing performed on XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n=5. Catheter performance crossability test measures average force to cross a challenging lesion Test performed by and data on file at Abbott. XIENCE Sierra Everolimus Eluting Coronary stent System ( x 18 mm) n=5, SYNERGY stent System ( x 20 mm) n=5, Resolute Onyx stent System ( x 18 mm) n= contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 7 of 13 UNIQUELY DESIGNED TO POST-DILATE TO mmExpanded Treatment Options1 Shortening (%) average at maximum expansion of Shortening (%) mmMaximum expansion for mm and mm 1.

9 Increased maximum expansion compared to other XIENCE Everolimus Eluting Coronary stent contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 8 of 13 ENSURES COATING INTEGRITY2 EVEN AT MAX EXPANSIONE xpanded Treatment Options11. Increased maximum expansion compared to other XIENCE Everolimus Eluting Coronary stent Test performed by and images on file at Sierra ( x 18 mm) 25x magnification at max expansion of mmXIENCE Sierra ( x 18 mm) 150x magnification at max expansion of mm SYNERGY ( x 20 mm) 25x magnification at max expansion of mm SYNERGY ( x 20 mm) 150x magnification at max expansion of mm Resolute Onyx ( x 18 mm) 25x magnification at max expansion of mm Resolute Onyx ( x 18 mm)

10 150x magnification at max expansion of mmSYNERGY coating shows multiple cracks with delamination at its max expansion of mm from mmResolute Onyx coating peels off and shows exposed metal at its max expansion of mm from mmXIENCE Sierra coating remains intact at maximum post-dilatation expansion of mm from mmInformation contained herein for distribution outside the only. Check the regulatory status of the device before distribution in areas where CE marking is not the regulation in force. 2017 Abbott. All rights reserved. AP2944678-OUS Rev. A Page 9 of 13 ENSURES COATING INTEGRITY2 EVEN AT MAX EXPANSIONE xpanded Treatment Options11. Increased maximum expansion compared to other XIENCE Everolimus Eluting Coronary stent Test performed by and images on file at Sierra coating remains intact at maximum post-dilatation expansion of mm from mm XIENCE Sierra ( x 18 mm) 25x magnification at max expansion of mmXIENCE Sierra ( x 18 mm) 150x magnification at max expansion of mm SYNERGY coating shows multiple cracks with delamination at its max expansion of mm from mmSYNERGY ( x 20 mm) 25x magnification at max expansion of mm SYNERGY ( x 20 mm) 150x magnification at max expansion of mm Resolute Onyx coating peels off and shows exposed metal at its max expansion of mm from mmResolute Onyx ( x 18 mm) 25x magnification at max expansion of mm Resolute Onyx ( x 18 mm)