Introduction - HORIBA Scientific

1 2 3 Introduction Welcome to the 2nd annual RamanFest Conference. RamanFest, an international two day event, offers presentations and discussions on the current state of advanced applied raman spectroscopy . This year s event is being held in conjunction with Harvard University, and is being chaired by: Professor Sunney Xie of Harvard University Dr. Dan Fu of Harvard University Dr. Andrew Whitley of HORIBA Scientific We are holding a gala dinner at the Sheraton Commander Hotel on Thursday evening. Our Guest Speaker is Professor Mildred Dresselhaus of MIT. RamanFest Book of Abstracts 4 - 5 Poster 6 Presentation Pages 7 - 22 Poster Abstracts (Posters will be available all day).

2 Pages 23 - 35 Speaker Pages 36 - 47 A tour of Professor Sunney Xie s laboratory at Harvard University is scheduled for Friday, June 13th, at the conclusion of RamanFest. 4 RamanFest Agenda Thursday, June 12, 2014 Note: Posters will be available all day 8:15 Registration / Sign In / Continental Breakfast and Coffee 9:30 Welcome by Prof. Sunney Xie and Dr. Andrew Whitley 9:45 Dr. Fran Adar ( HORIBA Scientific , Edison, NJ) raman spectroscopy Developments and Applications - Past, Present and Future 10:20 Prof. Ping-Heng Tan (Institute of Semiconductors, Chinese Academy of Sciences, P. R. CHINA) Ultra-low-frequency raman Modes in Two-dimensional Layered Materials 10:55 Coffee 11:30 Dr.

3 Michael J. Pelletier (Pfizer Global Research & Development) Pharmaceutical Polymorph Discrimination using Low- wavenumber raman spectroscopy 12:05 Prof. Lukas Novotny (ETH Z rich) Near-field raman Microscopy and spectroscopy of Carbon Nanotubes 12:40 Lunch 14:00 Prof. Christian Pellerin (University of Montreal, Canada) raman spectroscopy of Individual Electrospun Fibers 14:35 Dr. Neil Everall (Intertek-MSG) Industrial Problem Solving with raman spectroscopy 15:10 Coffee 15:45 Dr. The-Quyen Nguyen (Northwestern University) raman spectroscopy goes out helping patients in operating room 16:20 Prof. Igor K Lednev (University at Albany, SUNY ) Supremacy and Variety of Vibrational spectroscopy for Probing Amyloid Fibrils: from UV raman to VCD and TERS 16:55 End of Day 1 of RamanFest Symposium 18:30 Gala Evening Dinner at the Sheraton Commander Hotel George Washington Ballroom Guest Speaker: Prof.

4 Mildred Dresselhaus My Forty-Year Adventure with raman spectroscopy , and the Future 5 Friday June 13, 2014 Note: Posters will be available all day 8:15 Continental Breakfast and Coffee 9:15 Prof. Sanford A. Asher (University of Pittsburgh) UV raman Studies of Protein and Peptide Structure and Folding Studies 9:50 Prof. Igor Chourpa (University of Tours) SERS and Fluorescence as Analytical Tools to Study Theranostic Nanosystems 10:25 Prof. Ji-Xin Cheng (Purdue University) Microsecond Time Scale Spectroscopic Imaging for In vivo Molecular Analysis 11:00 Coffee 11:35 Prof. Paul Champion (Northeastern University) Coherent Low-frequency Vibrational Motion in Proteins and Biomolecules 12:10 Prof.

5 Lawrence D. Ziegler (Boston University) In Vitro Cellular Activity Probed by SERS: Applications for Diagnostics and Forensics 12:45 Lunch 14:15 Prof. Wei Min (Columbia University) Bioorthogonal Nonlinear Vibrational Imaging 14:50 Prof. Sunney Xie (Harvard University) Label Free Vibrational Imaging for Medicine 15:25 Round Table and Concluding Remarks 16:00 Visit to Prof. Sunney Xie Laboratories 6 Poster Titles 1. Characterization of Renal Ischemia Metabolites in the Mammalian Kidney using raman spectroscopy Fran Adar1, Neal Patel2, Joseph Barone2 and Ephrem O. Olweny2 2. Surface Enhanced raman spectroscopy using a Novel Substrate for Environmental Applications Mark Creelman, Aran Paulus, Robert Chebi, Iuliu Blaga, Ezra Van Gelder, Richard A.

6 Mathies, and Fanqing Frank Chen 3. UV Resonance raman and Fluorescence Spectroscopies with QM/MD Calculations Characterize Trp Protein Environment Azaria S. Einsenberg and Laura J. Juszczak 4. Study of Stresses in Hard Materials using raman and Photoluminescence spectroscopy Rudolph M. Erasmus 1,2, Maxwell Vhareta 1,2, J. Darrell Comins 1,2 5. Wafer-scale Aluminum Nano-plasmonics M. George, S. Nielson, and E. Gardner 6. Simple and Accurate New Method for Orientation Quantification using Polarized raman spectroscopy Marie Richard-Lacroix and Christian Pellerin 7. raman spectroscopy for Electrochemical Energy Storage and Conversion Nir Pour, Wesley T. Hong, Milind J. Gadre, Yueh-Lin Lee, Dane Morgan, Yang Shao-Horn 8.

7 Surface-Enhanced raman Scattering of Antibody Functionalized Gold Nanoparticles for the Detection of Cardiovascular Biomarkers In Vitro Marinella Sandros 9. Confocal raman Micro- spectroscopy Discriminates Live Human Metastatic Melanoma and Skin Fibroblast Tells Andrew C. Terentis*, Sara A. Fox, Samantha J. Friedman, and Emily S. Spencer 10. Vertical Integration of raman spectroscopy into the Chemistry Curriculum Evonne Rezler, Andrew Terentis, Jerome Haky 11. Polyaniline-Gold Substrates for EC-SERS Biosensing Applications Ryan West, NIST 12. Toward a high-throughput and Depth-Accurate 3-D characterization of Carbon Nanotube-Polymer Composites using Confocal raman Microscopy Minhua Zhao1,3,*, Doyoung Moon2, Kalman Migler2, J.

8 Alexander Liddle1 and Rachel J. Cannara1 13. Use of Digilab s raman Plate Reader IDENTITY for HTS Applications in Chemistry and Biology Igor Zlatkin, Digilab Inc. 7 Abstracts Dr. Fran Adar HORIBA Scientific raman spectroscopy : The Synergism between the Instrumentation Evolution and the Emerging Applications Dr. John Chalmers and Dr. Fran Adar The evolution of the instrumentation used to detect the raman effect, from the initial instrument used by CV raman himself, through to the current use of multichannel detectors on grating-based spectrographs with microscope sampling devices, will be reviewed, while indicating what fields of science have been explored during these time periods. In the earliest period we will indicate how raman spectra were originally used as an aid to determine molecular structure.

9 During the 1960 s it was successfully used to study the physics of semiconducting materials and devices. The Introduction of the microscope in ~1974 as a sampling device first simplified experimental conditions, but also provided information on a scale commensurate with many questions of microstructure and with problems of manufacturing defects. Curiously, while the original concept of the microscope in the early 1970 s was focused on raman imaging, technological limitations prevented its practical implementation. As the ability to acquire high quality map data over a region of interest improved, development of multivariate statistical means of treating the data has provided high quality raman images that are now yielding solutions to problems.

10 8 Prof. Ping-Heng Tan Institute of Semiconductors, Chinese Academy of Sciences, P. R. CHINA Ultra-Low-Frequency raman modes in two-dimensional layered materials The fast progress of graphene research, fuelled by the unique properties of this two dimensional (2D) material, paved the way to experiments on other 2D layered materials (LM).[1] Atoms within each layer in 2D LMs are held together by covalent bonds, while van der Waals interactions keep the layers together. The interlayer van der Waals (vdW) coupling and low frequency phonon modes, and how they evolve with the number of layers, are important for both the mechanical and electrical properties of 2D layered materials. We will address the recent advance on the experimental micro- raman technique to access the ultra-low phonon mode in 2D LMs.