IPCS Concise International Chemical Assessment …

1 IPCS UNEP//ILO//WHO Concise International Chemical Assessment Document ethylene glycol : human health aspects (2002 2006 2 1. ---------------------------------------- ---------------------------------------- ------- 4 2. ---------------------------------------- -- 6 3. ---------------------------------------- ---------------------------------------- - 7 4. ---------------------------------------- -------------------- 7 ---------------------------------------- ---------------------------- 7 ---------------------------------------- ------------------------------------- 8 5. ---------------------------------------- --------------- 8 ---------------------------------------- ---------------------------------- 8 ---------------------------------------- ---------------------------------------- ---- 9 ---------------------------------------- ---------------------------------------- ---- 9 ---------------------------------------- ---------------------------------- 10 ---------------------------------------- --------------------- 11 ---------------------------------------- --------------------- 13 6.)

2 ---------------------------- 14 7. in vitro ------------------------------------ 15 ---------------------------------------- --------------------------------------- 15 ---------------------------------------- ------------------------------------ 16 ---------------------------------------- --------------------------------- 16 ---------------------------------------- ------------------------ 19 ---------------------------------------- --------------------------------------- 20 ---------------------------------------- ---------------------------------------- ----- 21 ---------------------------------------- ------------ 24 ---------------------------------------- --------------------------------- 24 8. ---------------------------------------- ----------------------------------- 27 9.

3 ---------------------------------------- ----------------------------- 28 ---------------------------------------- --- 28 ---------------------------------------- ------------------------------------- 28 ---------------------------------------- ------------------------------------- 29 ---------------------------------------- 30 ---------------------------------------- ------------------------------------- 31 ---------------------------------------- ------------------------------------- 34 ---------------------------------------- ------------------------------------- 34 ---------------------------------------- ------------------------- 35 -------------------- 35 10 ---------------------------------------- ----------- 38 ---------------------------------------- ---------------------------------------- ------- 39 1 ---------------------------------------- -------------------------------- 54 2 CICAD ---------------------------------------- ------------ 56 3 CICAD ---------------------------------------- --------- 58 (ICSC0270) ---------------------------------------- ---------------- 56 4 Concise International Chemical Assessment Document ethylene glycol : human health aspects 1.

4 ( ) CICAD (Canadian Environmental Protection Act CEPA) (Priority Substances Program) CEPA CICAD 2000 1 1 1 (Environmental Criteria Assessment Office)(US EPA, 1987) (Agency for Toxic Substances and Disease Registry)(ATSDR, 1997) (BUA, 1994) BIBRA (1996, 1998) CICAD 2 CICAD 2001 10 29 11 1 3 IPCS (ICSC 0270)(IPCS, 2000a) CICAD CICAD No. 22 (IPCS, 2000b) (CAS No. 107-21-1) 1 5 (PET PETE) ( ) 2 in vitro in vivo ( ) ( )

5 ( ) 3 6 ( ) 1 49mg/kg 1000 1 mg/kg 2. (CAS No.)

6 107-21-1) 2 ( ) 7 (20 C 7 12 Pa) 10 6 10 3 Pa m3/mol 100 2 (log Kow) 20 C 1 ppm = mg/m3 1 mg/m3 = ppm ( health Canada, 2000) (ICSC 0270) 3. 1 kg mg mg L mg (ATSDR, 1997) (HPLC) (hexane) 4. CICAD CICAD No. 22 (IPCS, 2000b) Tricholoma matsutake (Ahn & Lee, 1986) ( ethylene ) (Blomstrom & Beyer, 1980) 8 9 CIS(Camford Information Services, 1977) 1 (polyethylene terephthalate)(PETE) (ATSDR, 1993.

7 Lewis, 1993) ( - - -) 1992 524 1999 907 (CIS, 1997) 1996 810 ( - - -) 1996 (CIS, 1997) ( ) 66 (105 ) (CIS, 1997) 1996 (Environment Canada, 1997) 1996 PETE 25 ( ) 6 (CIS, 1997) 1995 1996 (Environment Canada, 1997) 5. CICAD No. 22(IPCS, 2000b) CICAD ChemCan 1996 ( 374 ) 99 1 100 50 25 g/m3 (Environment Canada, 1997) Percy(1992) < (< ) (Abdelghani et al.

8 , 1990) 44 (Gaetano & Matta, 1987) (Gaetano & Matta, 1987; Kaiser & Rieder, 1987) (Takei, 1988) ( ethylene oxide) Buquet Manchon (1970) (carbonic anhydride) 150 ( ) Chaigneau Muraz (1993) 16 PETE (RCF) (Kashtock & Breder, 1980; Castle et al., 1988a; Kim et al., 1990) 11 Kashtock Breder (1980) 32 C PETE 3 ( ) 6 104 g/L (RCF) Castle (1988a) RCF ( ) 4 14 34mg/kg 4 3 22mg/kg 4 2 22mg/kg 4 34mg/kg 6 10mg/kg 85 (US EPA, 1986) (ATSDR, 1997) 50 (Franklin Associates Ltd.

9 , 1995) 14wt ( ) (Flick, 1986, 1989) 3wt ( ) (US EPA, 1986) Flick (1986) 4 (EPA)(1986) (US EPA, 1986) Chang (1997) 1992 85 4 ( ) 11 5wt (Environment Canada, 1997) Flick(1986) 12 (3wt ) ( ) (CEPA) ( ethylene chlorohydrin) Manius(1979) 15 4 10 28mg/L ( 6mg/L) (C. Denman, personal communication, 1999)

10 13 14 15 2 22 88 g/kg / RCF PETE 2 3 1 g/kg g/kg RCF ( ) ( health Canada, 2000) 100 4 1 236 g/kg / 4 1 16 ( 156 48)