IPCS Concise International Chemical Assessment Document …

1 IPCS UNEP//ILO//WHO Concise International Chemical Assessment Document resorcinol (2006) 2009 2 1. ---------------------------------------- ---------------------------------------- --------- 5 2. ---------------------------------------- ------- 10 3. ---------------------------------------- ---------------------------------------- ------ 12 4. ---------------------------------------- ------------------------- 13 5. ---------------------------------------- ---------------- 19 6. ---------------------------------------- ------------------- 23 7.

2 ------------------------------------ 29 8. in vitro ---------------------------------------- - 31 in vitro in vivo in vivo in vitro in vivo in vitro 9. ---------------------------------------- ---------------------------------------- ----- 50 10. ---------------------------------------- ------------ 54 11.

3 ---------------------------------------- ---------------------------------------- -------- 58 12. ---------------------------------------- ------------------- 66 ---------------------------------------- ---------------------------------------- ---------------- 67 APPENDIX 1 ACRONYMS AND ABBREVIATIONS -------------------------------- 92 APPENDIX 2 SOURCE DOCUMENTS ---------------------------------------- -----------95 APPENDIX 3 CICAD PEER REVIEW ---------------------------------------- -------------97 APPENDIX 4 CICAD FINAL REVIEW BOARD --------------------------------------- 99 APPENDIX 5 ESTIMATION OF ENVIRONMENTAL CONCENTRATIONS -101 APPENDIX 6 REPEATED-DOSE TOXICITY ---------------------------------------- --115 APPENDIX 7 TWO-GENERATION STUDY DESIGN ------------------------------121

4 (ICSC 1033) -----------------------------123 5 ( Concise International Chemical Assessment Document ) resorcinol ( ) 1. CICAD1 (Fraunhofer Institute of Toxicology and Experimental Medicine) BUA(1933) MAK (MAK, 2003) (Health Council of the Netherlands) (2004) (USEPA) (HPV) (HPV Challenge Program)(INDSPEC, 2004) (IUCLID) Appendix 2 2005 2 CICAD Appendix 3 CICAD 2005 10 31 11 3 (Nagpur) Appendix 4 (ICSC 1033)(IPCS, 2003) CICAD CICAD (OECD) (HPV Chemicals Programme)

5 CICAD 2005 8 9 OECD OECD OECD IPCS (CAS 108-46-3) n 1 Appendix 1 6 ( 50 ) ( 25 ) ( 2 ) (BCF) EUSES( )

6 1 7 (CNS) F344 B6C3F1 5 (17 ) (NOAEL) 75 mg/kg F344 B6C3F1 13 (LOAEL) 28 32 mg/kg NOAEL 32 mg/kg ( 5 ) (420 520 mg/kg ) F344 B6C3F1 0 225 mg/kg F344 0 150 mg/kg 5 104 (NTP, 1992) 100 mg/kg NOAEL 50 mg/kg 0 225 mg/kg 5 24 26 CB6F1-Tg rasH2 (nitrosamine) 3 8 TK in vitro DNA DNA in vitro (SCE)

7 In vivo ( 2 SCE) 360 mg/L 28 (RTF, 2003) 0 120 360 1000 3000 mg/L (NOEL) 1000 mg/L NOAEL 3000 mg/L (F0 F1 ) NOAEL 233 mg/kg / 304 mg/kg / 660 mg/kg / (RTF, 2005) 6 15 500 mg/kg (24 72 ) 667 mg/kg 5 mg/kg / 30 12 13 0 130 mg/kg (T3/T4) (104 ) NOAEL 150 520 mg/kg / ( 5 ) (NTP, 1992) 360 mg/L ( 1 4 13 37 mg/kg /.)

8 1 5 16 47 mg/kg / ) (RTF, 2003) (RTF, 2005) F0 F1 F1 F2 ( 4 21 ) T3 T4 (TSH) F0 TSH 9 T3 T4 3000 mg/L F0 in vitro 2 ( 50 ) NTP(1992) ( ) NOAEL 50 mg/kg / ( 5 36 mg/kg / ) T3/T4 10 mg/kg / 2 ( T3/T4/T7/TSH ) 12 mg/kg / ( mg/kg / ) NTP(1992) mg/kg / 10 (21 NOEC=172 g/L) (NOEC) (Daphnia magna)

9 NOEC 2 ( ) EU (EU Technical Guidance Document )(EC, 2003a) 50 (PNEC aqua) g/L (PNEC) (PEC) ( ) (PEC/PNEC) PEC/PNEC 2.

10 (CAS 108-46-3) (Schmiedel & Decker, 2000) C6H6O2 IUPAC 1,3- (1,3-dihydroxybenzene) 1,3- 11(1,3-benzenediol) m- (m-benzenediol) m- (m-dihydroxybenzene) m- (m-hydroquinone) 3- (3-hydroxyphenol) (resorcin) OH Figure 1 2 ( ) (Kofler, 1943) 71 C (Schmiedel & Decker, 2000) (Kirk-Othmer, 1981; O Neil, 2001) (Health Council of the Netherlands, 2004) pKa (25 C) (pH5 8) pH8 2 pH5 o- (o-cresol) m-/p- 3- (3-mercaptophenol) 2 Table 1 (ICSC 1033) kPa 20 C 2 2 (SI) WHO CICAD SI SI (20 C kPa) 2 12 1 ppm = mg/m 1 mg/m = ppm 3.