IPCS Concise International Chemical Assessment Document …

1 IPCS UNEP//ILO//WHO Concise International Chemical Assessment Document Barium and Barium Compounds(2001) 2006 2 1.. 4 2.. 7 3.. 7 4.. 9 5.. 10 6.. 12 .. 12 .. 14 7.. 16 8. in vitro .. 19 .. 19 .. 20 .. 20 .. 20 .. 23 .. 25 .. 26 .. 26 9.. 26 .. 26 .. 28 10.. 32 .. 32 .. 33 11.. 33 .. 33 .. 35 .. 37 .. 38 .. 38 ( ).. 39 .. 40 .. 40 312.. 41 .. 43 1 .. 58 2 CICAD.

2 61 3 CICAD .. 63 4 (ICSC1052).. 65 (ICSC0613).. 66 (ICSC0614).. 67 (ICSC0615).. 68 (ICSC0778).. 69 (ICSC0381).. 70 (ICSC0827).. 71 4 ( Concise International Chemical Assessment Document ) Barium and Barium compounds ( ) 1. CICAD WHO (IPCS, 1990) (EPA) (United Kingdom s Health and Safety Executive)(HSE) EPA Toxicological review of barium and barium compounds(US EPA, 1998) (Agency for Toxic Substances and Disease Registry) Toxicological profile for barium(ATSDR, 1992) HSE Barium sulphate risk Assessment Document (Ball et al., 1997) EPA (1998) (1998 ) 1999 1 1997 9 HSE 1999 4 1 CICAD 2 CICAD 2000 6 26 29 3 IPCS(IPCS, 1993, 1999a-f) (ICSC 1052) (ICSC 0613) (ICSC 0614) (ICSC 0615) (ICSC 0778) (ICSC 0381) (ICSC 0827) CICAD 5 ( ) (III) ( )

3 44 m 30 6 m 2 ( ) ( ) (450g) 6 40mg/m3 5 1 5 in vivo in vitro

4 Estimation and Assessment of Substance Exposure(EASE) 8 10mg/m3( ) 10mg/m3 (NOAEL) /kg / / CICAD 7 2. (Ba; CAS No. 7440-39-3) IIA 56 (ATSDR, 1992) (CAS No. 7727-43-7) (CAS No. 513-77-9) (20 C) (0 C) (III) barite barytes heavy spar blanc fixe 20 C 375g/L (ICSC) 3.

5 1 NIOSH(1987) 1 2 g 1 43 180 g (US OSHA, 1990) 8 ppb ppt X (ATSDR, 1992) ( ) 9 7 g/L 66 g/L (ATSDR, 1992) 4. 16 ( ) ( ) 3000 mg/kg (IPCS, 1990.)

6 ATSDR, 1992) 250 g/ (Considine, 1976) 90 98 1985 570 (IPCS, 1990) 44 m 30 6 m X ( ) 10 (IPCS, 1990) 1998 900 45 9300 1 5.

7 Kd( ) 105 mL/g (McComish & Ong, 1988) 10 m Cartwright 1978 1 (Toxic Chemical Release Inventory)(TRI) (Office of Toxic Substances) ( ) 1998 11 (Chow et al.)

8 , 1978) (IPCS, 1990) 15 30 60 (Havlik et al., 1980) Scenedesmus obliquus pH4 7 (133Ba) 7 9 10 6 mol/L (Km) (Stary et al., 1984) Guthrie (1979) mg/kg (Clark & Washington, 1924) (Bradfield, 1932; McComish & Ong, 1988) (McComish & Ong, 1988) (US EPA, 1984) Fraxinus pennsylvanica (Juglans nigra) (Carya sp.

9 (Bertholletia 12excelsa) (Pseudotsuga menziesii) Astragallu (IPCS, 1990) (Aruguete et al., 1998) (Gormican, 1970; IPCS, 1990) mg/kg( [SEM] ) ( [SEM ]) (BCF) ( ) (Hope et al., 1996) ( ) (Peromyscus leucopus) (SEM ) (Sigmodon hispidus) (SEM ) mg/L(SEM ) ( [ SEM]) BCF L/kg (SEM ) (SEM ) (SEM ) (IPCS, 1990) 6.

10 Tabor Warren (1958) 18 4 mg/m3 (Tabor & Warren, 1958; Schroeder, 1970) mg/m3 (US EPA, 1984) 3 (Creason et al., 1975) (US EPA, 1974) 13 137mg/g 20mg/g (NAS, 1977) (NAS, 1977) 7 15mg/L 6mg/L (Schroeder et al., 1972) 43 57mg/L (Durum, 1960; Kopp, 1969; Kopp & Kroner, 1970; Schroeder, 1970; Bradford, 1971) 450 3000mg/kg(Tsai et al., 1978) 10mg/L (Durfor & Becker, 1964; Barnett et al., 1969; McCabe et al.)