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Irreversible Inhibition Kinetics: Biochemical Rate ...
Irreversible Inhibition Kinetics 35 PK / PK simulations: Summary and conclusions • Both binding and reactivity are important for cellular potency a s i g n i d n i •B necessary but not sufficient precondition • Reactivity is a necessary but not sufficient precondition
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Why IC50’s Are Bad for You - BioKin Ltd
www.biokin.com1 Why IC 50’s Are Bad for You And Other Surprises Petr Kuzmič, Ph.D. BioKin, Ltd. IC50's are bad for you 2 What is enzyme inhibition on the molecular level “Drugs produce their inhibitory action by combining with the enzyme [molecules].”
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