Jan-Dries Luijks Euroblight Workshop, Aarhus, …

1 Jan-Dries LuijksEuroblightWorkshop, aarhus , denmark , May 16, 2017 dupont Zorvec (oxathiapiprolin) is not registered for sale or use in all countries. No offer for sale, sale or use of this product is permitted prior to issuance of the required country level registrations. The information contained in this technical presentation is based on the latest to-date technical information available to dupont , and dupont reserves the right to update the information at any time. 2 Multiple effects on pathogen s life cycle Superior rainfastness Systemic movement Protects new leaf growth Excellent field efficacyNovel site and mode-of-actionFavorable environmental profilePotato late blight (Phytophthora infestans)Source.

2 dupont trials in Indonesia (top photo) and the United Kingdom (bottom photo) dupont Zorvec Anunmatched combination of consistency and control that can be used every season to help achieve a better crop, even under challenging environmental conditionsEXCELLENT OOMYCETE DISEASE CONTROL TECHNOLOGY3 Trade nameDuPont Zorvec diseasecontrolChemicalclasspiperidinyl thiazole isoxazolineCommon chemical nameoxathiapiprolinMolecular formulaC24H22F5N5O2 SChemical structureCASnumber1003318-67-9 Disease spectrumControls diseasescaused by oomycete pathogensGENERAL INFORMATIONNew Answers Improved effectiveness and favorable environmental profile Oomycete specific OSBP domain Highly selective against Phytophthora and downy mildew species for reduced environmental load Very low toxicity to a number of non-target organismsDuPont Zorvec New site and mode of action

3 Deliver effective control and a favorable environmental profile with no cross resistance Provides a new tool for integrated pest managementEFFECTIVE CONTROL AND FAVORABLE PROFILEHow Zorvec Delivers5* dupont Zorvec disease control is recommended for use in a preventive mannerSource: Based on laboratory studies with Phytophthora infestans, dupont Stine-Haskell Research Center, USA 2011-2012 Preventive activity Inhibits zoospore release Prevents zoospore germination Prevents sporangia germinationCurative activity* Stops mycelial growth in the host plant before visible symptoms occurPost infection activity* Delays further lesion growthAntisporulant activity Inhibits spore production Inhibits spore viabilityIn-season life cycle of Phytophthora infestans (late blight) dupont Zorvec Multiple effects on the pathogen s life cycle provide unmatched consistency and control for a healthier cropP.

4 Infestansmycelial growth within a potato leafMULTIPLE EFFECTS ON THE LATE BLIGHT LIFE CYCLEDuPont Zorvec disease control is recommended for use in a preventive manner6 Based on laboratory studies with Phytophthora infestans. Effect on zoospore release varies between species. Source: dupont Stine-Haskell Research Center, USA 2011- 2012In vitro test type Zorvec EC50 , ppmcyazofamidEC50 , ppmmandipropamidEC50 , ppmZoospore germination < < direct germination < > growth > < > activity against Phytophthora infestans Highly active Inactive*EC50= concentration needed to inhibit 50% of the population* Inactive at concentrations used in these studiesDuPont Zorvec Multiple effects on the pathogen s life cycle at very low concentrationsprovide better efficacy, efficiency and length of controlMULTIPLE EFFECTS7 dupont Zorvec Excellent preventive activity protects plants from damage.

5 Promoting healthy crop growthgerminating zoosporeviable (living) zoosporesnon-living zoosporesnon-released sporangiaDuPont Zorvec RED: non-viable spores, unable to germinateUntreatedGREEN: live, viable spores Inhibits spore viability and germination Based on laboratory studies with Phytophthora infestans. Source: dupont Stine-Haskell Research Center, USA 2012 PREVENTIVE ACTIVITY8 dupont Zorvec Excellent preventive activity protects plants from damage,promoting healthy crop growthDuPont Zorvec UntreatedInhibits spore viability and germination Based on laboratory studies with Phytophthora infestans. Source (photos): Biotransfer SA, France 2014 Zorvec prevents zoospore germination as indicated by the lack of germ tube formation (left photo)germ tube PREVENTIVE ACTIVITY9 dupont Zorvec Excellent preventive activity protects plants from damage,promoting healthy crop growthDuPont Zorvec Untreated, germinated sporangiaPrevents sporangia germination Based on laboratory studies with Phytophthora infestans.

6 Source: dupont Stine-Haskell Research Center and University of Delaware Bioimaging Center, USA 2014 Non-germinated sporangiaIrregular sporangiaPREVENTIVE ACTIVITY10 dupont Zorvec Consistently excellent disease control at much lower rates Excellent control of stem blight as well as foliar late blight for more consistent control throughout the crop canopy Source: Whole plant studies, dupont Stine-Haskell Research Center, USA 2014 Excellent stem blight controlGAH:g ai/haZorvec 15 GAHdimethomorph400 GAHmandipropamid150 GAHfluopicolide +propamocarb1100 GAHcyazofamid80 GAHPREVENTIVE ACTIVITY11 dupont Zorvec Excellent disease control enables better farm management Curative action at rates much lower than competitive products Improves efficiency and offers protection when farm conditions force preventive* application delays* dupont Zorvec disease control is recommended for use in a preventive mannerSource (photos): Biotransfer SA, France 2014 dupont Zorvec Untreated Florescence microscopy used to visualize mycelial growth within leaf tissue prior to first visible symptoms.

7 Zorvec applied post-infection (curative*) inhibits mycelial growth in plant growth inside the leaf prior to visible symptomCURATIVE12 UntreatedDuPont Zorvec Excellent anti-sporulant activity enables better farm management Protects at much lower rates than competitive products Prevents secondary spread of disease, improving overall protectionGAH:g ai/haInhibits sporulation on existing lesionsSource: Whole plant studies, dupont Stine-Haskell Research Center, USA 2014 Zorvec 15 GAHdimethomorph300 GAHmandipropamid150 GAHfluopicolide + propamocarb1100 GAHANTISPORULANT ACTIVITY13 DAT = Days after treatmentSource: dupont Stine-Haskell Research Center, USA 2012 DPX-QGU42 100OD vs Revus partitioning0%20%40%60%80%100%1hr3 DAT7 DAT1hr3 DAT7 DATDPX-QGU42 100 ODRevus Percent RecoveredPenetrated Residues (Leaf Extract)Waxy Layers (Solvent Wash)Leaf Surface (Water Wash) dupont Zorvec Leaf partitioning following a preventive applicationDuPont Zorvec A significant portion of Zorvec is absorbed on and within the epicuticular waxy layer following application providing superior rainfastness Controlled washoff studies have demonstrated Zorvec is secure and protected from wash-off just 20 minutes after applicationmandipropamidNote.

8 Chart depicts partitioning expressed as a percent (%) of total ai recoveredSUPERIOR RAINFASTNESSR ainfastness is related to how quickly an active moves into plant tissue14 Potato late blight control following a simulated rain event * dupont Zorvec 15 GAH GAH mandipropamid 150 GAH GAH mancozeb 1600 GAH dupont Zorvec Superior rainfastness at low rates compared with competitive products Significantly reduces shadowing effect caused by overlapping leaves for more consistent control throughout the crop canopy Source: dupont Stine-Haskell Research Center, USA 2014*60 mm over 2 hours starting 20 minutes after applicationUnwashedWashedWashedWashedWas hedWashedGAH:g ai/haSUPERIOR RAINFASTNESS15 dupont Zorvec Translaminar and acropetal systemic movement within plant tissue enables uniform coverage of foliage and protection from wash-offby rain Half the leaf protected from spray Entire leaf inoculated with late blightSource: dupont Stine-Haskell Research Center, USA 2013 dupont Zorvec SYSTEMIC MOVEMENT161 dupont Zorvec Protects new leaf growth for better crop establishment Protects treated leaves as they grow and expand Protects new leaves as they emerge and growSource.

9 Field-to-lab study, dupont Stine-Haskell Research Center, USA 2014 Fungicide application(300L/ha)0day10days15daysPlan t sampled and lab inoculationEvaluation-1dayStems taggedPROTECTS EMERGING GROWTH1 dupont Zorvec Protects new leaf growth for better crop establishment Protects treated leaves as they grow and expand Protects new leaves as they emerge and growSource: Field-to-lab study, dupont Stine-Haskell Research Center, USA 201410 days020406080100 Zorve c, 15 GA HRevus, 150 GAHInf inito, 1100 GAHP ercent controlProtection of expanding and emerging plant growthExpanding GrowthEmerging GrowthNe w Axi ll ary Growthmandipropamid150 GAHfluopicolide +propamocarb1100 GAHZ orvec 15 GAHPROTECTS EMERGING GROWTHP lants removed from field ten ( 10) days after application and inoculated with aPhytophthora infestans spore suspensionZorvec dupont Zorvec Consistently excellent disease control at low use ratesSource (photo): dupont -sponsored Indonesia field trial, 2013 ROBUST FIELD EFFICACYRev.

10 28 Sept 2016To help protect product performance: Apply preventively before first visible signs of disease Apply only in mixtureswith a different mode of action fungicide(s) Apply using a 7-10 day spray interval, use shorter interval when disease is present in the area or when weather conditions favor disease development Resistance managementreduces the risk of resistance development and helps protect product performance over time dupont ZORVEC RESISTANCE MANAGEMENT20 Rev: 28 Sept 2016 Days203040506080100120 Planting 0102030406080100 Emergenceemergence, growthrapid vegetative growthtuber initiationtuber bulkingharvest010203040506070200001000 Reduction in fresh weight (Kg/ha)Days after emergence20 days 50 days Target growth stage for Zorvec Starting at rapid growth through flowering for maximum late blight protection, crop vigor and yield POSITIONING ZORVEC IN A FUNGICIDE SPRAY PROGRAM21An unmatched combination of consistency and control that can be used every season to help achieve a bet