Transcription of 新藥介紹：Januvia® 佳糖維膜衣錠
1 1 Januvia 2006 10 17 FDA sitagliptin Januvia 2007 7 13 Januvia dipeptidyl peptidase 4 (DPP-4) metformin sulfonylurea glitazone 2 sitagliptin glucose-dependent insulinotropic polypeptide GIP Glucagon-like peptide-1 (GLP-1) K L incretin GIP GLP-1 GLP-1 GIP GLP-1 glucagon 2 GIP GLP-1 dipeptidyl peptidase 4 ( DPP-4 ) sitagliptin DPP-4 GIP GLP-1 2 sitagliptin 1 4 ( t1/2 )
2 87 % sitagliptin sitagliptin area under the curve AUC sitagliptin sitagliptin 100 CrCl: 50 <80 mL/min CrCl : 30 <50mL/min 50 CrCl : <30 mL/min 25 sitagliptin 2 sitagliptin 100 1.
3 sitagliptin 2. sitagliptin sulfonylurea sulfonylurea 3. sitagliptin B 4. sitagliptin sitagliptin 2
