Transcription of アフェレシス - jsao.org
1 Hajime NAKAE.. 1.. B PMX . 10 2 . PMX . 2005 Vincent . Shock 1) 2008 3) . 16 PMX . PMX PMX Sequential Organ Failure Plasma Dia-filtration PDF Assessment SOFA Risk, Injur y, Failure, Loss, Plasma Filtration with Dialysis 2 End-stage renal disease RIFLE . lipopolysaccharide LPS tumor necrosis factor- TNF- . 2. PMX . PMX . 1 7 . 2007 28 in vitro . 2) 19 mmHg 95 . 15 22 mmHg, P PMX . PMX g/kg/min . 95 , P LPS . PaO2 /F I O2 P/F 32 95 . 23 41, P B PMX . 95 . LPS . 4 PMX . TNF receptor type 1 TNF-R1 .. PMX 3 6 9 . 010-8543 1-1-1 . E-mail.. 38 3 2009 165. 1 MELD . MELD 20 29 30 39 40. PDF 8/12 3/9 0 0/7 . MARS 10) 12) 18/28 5/20 0 0/1 . 12) 2/3 0 0/1 . 13) 5/21 16. 7 1/6 . MARS , Molecular Adsorbent Recirculating System; MELD, the model for end-stage liver disease.
2 PDF, Plasma Dia-filtration. Bax 28 . Bcl-2 53 16/30 PMX 32 11/34 . Bax/Bcl-2 95 . PMX . Cr uz .. ZO-1 PMX PMX . ZO-1 . PMX. 3. PDF .. PDF EC-2A. EC-2A .. 5) EC-2A ethylene vinyl alcohol copolymer PMX EVAL m . m . PMX .. PMX 0 . 6) 8) . the model for 3 end-stage liver disease MELD . 2009 Cr uz PDF MELD .. 64 Molecular Adsorbent Recirculating System, MARS . 4) 1 1 9) 13) . P/F SOFA 28 . 4.. 2 . 1 PMX PMX randomized controlled trial RCT JAMA. 76 mmHg 84 mmHg 4) PMX . P P 53 . 2 PMX P/F PMX . P SOFA P RCT . 166 38 3 2009 . 26: 310-4, 2007. 6) .. Plasma filtrated Diafiltration 2 . 46: 482-5, 2006. 7) Nakae H, Igarashi T, Tajimi K, et al: A case repor t of hepatorenal syndrome treated with plasma diafiltration . (selective plasma filtration with dialysis).
3 Ther Apher Dial 11: 391-5, 2007. 8) Nakae H, Igarashi T, Tajimi K, et al: A case of pediatric fulminant hepatitis treated with plasma diafiltration. Ther Apher Dial 12: 329-32, 2008. 9) Plasma Dia-filtration 1) Vincent JL, Laterre PF, Cohen J, et al: A pilot-controlled PDF Plasma Filtration with Dialysis . study of a polymyxin B-immobilized hemoper fusion 28: 197-202, 2009. cartridge in patients with severe sepsis secondary to intra- 10) Evenepoel P, Laleman W, Wilmer A, et al: Prometheus abdominal infection. Shock 23: 400-5, 2005 versus molecular adsorbents recirculating system: 2) Cruz DN, Perazella MA, Bellomo R, et al: Effectiveness of comparison of efficiency in two different liver detoxification polymyxin B-immobilized fiber column in sepsis: a devices.
4 Artif Organs 30: 276-84, 2006. systematic review. Crit Care 11: R47, 2007 11) Faenza S, Baraldi O, Ber nar di M, et al: MARS and 3) Cantaluppi V, Assenzio B, Pasero D, et al: Polymyxin-B Prometheus: our clinical experience in acute chronic liver hemoperfusion inactivates circulating proapoptotic factors. failure. Transplant Proc 40: 1169-71, 2008. Intensive Care Med 34: 1638-45, 2008 12) Dethlof f T, Tofteng F, Frederiksen HJ, et al: Ef fect of 4) Cr uz DN, Antonelli M, Fumagalli R, et al: Early use of Prometheus liver assist system on systemic hemodynamics polymyxin B hemoperfusion in abdominal septic shock: the in patients with cirrhosis: a randomized controlled study. EUPHAS randomized controlled trial. JAMA 301: 2445-52, World J Gastroenterol 14: 2065-71, 2008.
5 2009 13) Wiesner RH, McDiarmid SV, Kamath PS, et al: MELD and 5) Plasma Dia-filtration PELD: application of sur vival models to liver allocation. PDF Plasma Filtration with Dialysis . Liver Transpl 7: 567-80, 2001. 38 3 2009 167.
